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Seung Yeon Hwang

Sungkyunkwan University · Medicine

About the Lab

Professor Seung Yeon Hwang's research lab specializes in critical care medicine, with a primary focus on identifying and validating biomarkers for early prediction of mortality in sepsis and septic shock. The lab investigates hemodynamic phenotypes, such as cryptic and overt shock, and evaluates the prognostic value of inflammatory markers (e.g., CRP, PCT) and metabolic indicators (e.g., lactate, albumin) in critically ill patients. Their work also explores the potential of adjunctive therapies, including vitamin C and thiamine, in improving outcomes such as delirium-free survival in septic shock. The lab employs multicenter, prospective, and retrospective observational studies to translate clinical biomarkers into actionable clinical tools.

sepsisseptic shockbiomarkerslactateprognosis

Research Overview

Papers
149
Total Citations
2,161
Papers (5y)
76
Primary Field
Medicine

Research Output Trend

Figures are computed from collected data and may differ slightly.

Publications per year (5y)
76total
2021
2022
2023
2024
2025
Citations per year (5y)
449total
20212022202320242025

Selected Papers

15
1
Article|230 citations·2016
Neutrophil-to-lymphocyte ratio as a prognostic marker in critically-ill septic patients
Sung Yeon Hwang, Tae Gun Shin, Ik Joon Jo, Kyeongman Jeon, Gee Young Suh, Tae Rim Lee, Hee Yoon, Won Chul, Min Seob Sim
SJR Q1The American Journal of Emergency Medicine
EpidemiologyMedicine
2
Article|157 citations·2020
Combination therapy of vitamin C and thiamine for septic shock: a multi-centre, double-blinded randomized, controlled study
Sung Yeon Hwang, Seung Mok Ryoo, Jong Eun Park, You Hwan Jo, Dong‐Hyun Jang, Gil Joon Suh, Taegyun Kim, Youn‐Jung Kim, Seonwoo Kim, Hyun Cho, Ik Joon Jo, Sung Phil Chung
SJR Q1Intensive Care MedicineOA
Nutrition and DieteticsNursing
3
Article|131 citations·2018
Prognostic Value of The Lactate/Albumin Ratio for Predicting 28-Day Mortality in Critically ILL Sepsis Patients
Jikyoung Shin, Sung Yeon Hwang, Ik Joon Jo, Won Young Kim, Seung Mok Ryoo, Gu Hyun Kang, Kyuseok Kim, You Hwan Jo, Sung Phil Chung, Young Seon Joo, Jin Ho Beom, Young‐Hoon Yoon
SJR Q1ShockOA

AIM: The aim of this study was to evaluate the clinical utility of the lactate/albumin (L/A) ratio as a predictive factor of 28-day mortality in critically ill sepsis patients. METHODS: This is a retrospective observational study from a prospectively collected multicenter registry of 10 emergency departments (EDs) in teaching hospitals that participated in the Korean Shock Society. It enrolled patients who were 19 years of age or older who had a suspected or confirmed infection and evidence of r

EpidemiologyMedicine
4
Article|117 citations·2017
Low Accuracy of Positive qSOFA Criteria for Predicting 28-Day Mortality in Critically Ill Septic Patients During the Early Period After Emergency Department Presentation
Sung Yeon Hwang, Ik Joon Jo, Se Uk Lee, Tae Rim Lee, Hee Yoon, Won Chul, Min Seob Sim, Tae Gun Shin
SJR Q1Annals of Emergency Medicine
EpidemiologyMedicine
5
Article|94 citations·2019
The usefulness of C-reactive protein and procalcitonin to predict prognosis in septic shock patients: A multicenter prospective registry-based observational study
Seung Mok Ryoo, Kap Su Han, Shin Ahn, Tae Gun Shin, Sung Yeon Hwang, Sung Phil Chung, Yoon Jung Hwang, Yoo Seok Park, You Hwan Jo, Hyunglan Chang, Gil Joon Suh, Kyoung Min You
SJR Q1Scientific ReportsOA

The objective of this study was to evaluate the prognostic value of C-reactive protein (CRP), procalcitonin (PCT), and their combination for mortality in patients with septic shock. This multicenter, prospective, observational study was conducted between November 2015 and December 2017. A total of 1,772 septic shock patients were included, and the overall 28-day mortality was 20.7%. Although both CRP and PCT were elevated in the non-survivor group, only CRP had statistical significance (11.9 mg/

EpidemiologyMedicine
6
Article|63 citations·2016
Impact of Metformin Use on Lactate Kinetics in Patients with Severe Sepsis and Septic Shock
Joong‐Min Park, Sung Yeon Hwang, Ik Joon Jo, Kyeongman Jeon, Gee Young Suh, Tae Rim Lee, Hee Yoon, Won Chul, Min Seob Sim, Keumhee C. Carrière, Seungmin Yeon, Tae Gun Shin
SJR Q1Shock

Lactate levels in metformin users were initially elevated in the early phase of resuscitation from severe sepsis and septic shock. However, there was no significant difference in lactate levels, LC, and normalization over the initial 24 h period based on metformin use.

EpidemiologyMedicine
7
Article|62 citations·2015
Comprehensive Interpretation of Central Venous Oxygen Saturation and Blood Lactate Levels During Resuscitation of Patients With Severe Sepsis and Septic Shock in the Emergency Department
Tae Gun Shin, Ik Joon Jo, Sung Yeon Hwang, Kyeongman Jeon, Gee Young Suh, Euna Choe, Young Kun Lee, Tae Rim Lee, Won Chul, Min Seob Sim
SJR Q1Shock

Oxygenation category, as represented by initial Scvo2 and lactate levels, was significantly associated with 28-day mortality in patients with severe sepsis or septic shock. Associations between Scvo2 ≥70% and 28-day survival were observed only in patients without severe lactic acidosis.

EpidemiologyMedicine
8
Article|54 citations·2019
N95 filtering facepiece respirators do not reliably afford respiratory protection during chest compression: A simulation study
Sung Yeon Hwang, Hee Yoon, Aerin Yoon, Taerim Kim, Gun Tak Lee, Kwang Yul Jung, Joo Hyun Park, Tae Gun Shin, Won Chul, Min Seob Sim, Seonwoo Kim
SJR Q1The American Journal of Emergency Medicine
Emergency MedicineMedicine
9
Article|22 citations·2014
Association Between Hemodynamic Presentation and Outcome in Sepsis Patients
Sung Yeon Hwang, Tae Gun Shin, Ik Joon Jo, Kyeongman Jeon, Gee Young Suh, Tae Rim Lee, Won Chul, Min Seob Sim, Keun Jeong Song, Yeon Kwon Jeong
SJR Q1Shock

We aimed to compare outcomes of sepsis patients according to their hemodynamic presentation: cryptic shock (CS), cryptic to overt shock (COS), and overt shock (OS). We analyzed the sepsis registry for adult patients who presented to the emergency department (ED) of a tertiary hospital and met the criteria for severe sepsis or septic shock between August 2008 and March 2012. We classified the patients as having CS, COS, or OS. "Cryptic shock" was defined as severe sepsis with a lactate level of 4

EpidemiologyMedicine
10
Article|22 citations·2020
Impact of Vitamin C and Thiamine Administration on Delirium-Free Days in Patients with Septic Shock
Jong Eun Park, Tae Gun Shin, Ik Joon Jo, Kyeongman Jeon, Gee Young Suh, Minsu Park, Hojeong Won, Chi Ryang Chung, Sung Yeon Hwang
SJR Q1Journal of Clinical MedicineOA

Sepsis is a common cause of delirium in the intensive care unit (ICU). Recently, vitamin C and thiamine administration has been gaining interest as a potential adjunct therapy for sepsis. We investigated the impact of early vitamin C and thiamine administration on ICU delirium-free days among critically ill patients in septic shock. We performed a single-center, retrospective study of patients who visited the emergency department (ED) from January 2017 to July 2018. We categorized patients into

Critical Care and Intensive Care MedicineMedicine
11
Article|21 citations·2019
C-MAC Video Laryngoscope versus Conventional Direct Laryngoscopy for Endotracheal Intubation During Cardiopulmonary Resuscitation
Byeong Chul Min, Jong Eun Park, Gun Tak Lee, Tae Rim Kim, Hee Yoon, Won Chul Cha, Tae Gun Shin, Keun Jeong Song, Minsu Park, Heewon Han, Sung Yeon Hwang
SJR Q2MedicinaOA

Background and objectives: To compare the first pass success (FPS) rate of the C-MAC video laryngoscope (C-MAC) and conventional Macintosh-type direct laryngoscopy (DL) during cardiopulmonary resuscitation (CPR) in the emergency department (ED). Materials and Methods: This study was a single-center, retrospective study conducted from April 2014 to July 2018. Patients were categorized into either the C-MAC or DL group, according to the device used on the first endotracheal intubation (ETI) attemp

Emergency MedicineMedicine
12
Article|18 citations·2018
Quality Improvement Program Outcomes for Endotracheal Intubation in the Emergency Department
Sung Yeon Hwang, Joo Hyun Park, Hee Yoon, Won Chul Cha, Ik Joon Jo, Min Seob Sim, Keun Jeong Song, Hyo Jung Woo, Sung Geun Jeong, Tae Gun Shin
SJR Q1Journal of Patient Safety

OBJECTIVES: We describe our 3-year experience with endotracheal intubation (ETI) outcomes during a multidisciplinary emergency department (ED)-based quality improvement (QI) program. METHODS: This was a single-center, observational study taking place during a QI program. We used a registry for airway management performed in the ED from April 2014 to February 2017. The QI program focused on procedural standardization, airway management education, and comprehensive preparation of airway equipment.

Anesthesiology and Pain MedicineMedicine
13
Article|16 citations·2019
Delayed Antibiotic Therapy and Organ Dysfunction in Critically Ill Septic Patients in the Emergency Department
Sung Yeon Hwang, Jikyoung Shin, Ik Joon Jo, Jong Eun Park, Hee Yoon, Won Chul Cha, Min Seob Sim, Tae Gun Shin
SJR Q1Journal of Clinical MedicineOA

BACKGROUND: We investigated the effect of antibiotic timing on outcomes based on changes in surrogate markers of organ failure, including platelet, serum bilirubin, serum creatinine levels, and the PaO₂/FiO₂ (P/F) ratio. METHODS: This was a single-center, retrospective observational study of critically ill septic patients who presented to the emergency department (ED). The study period extended from August 2008 to September 2016. The primary outcomes included changes in platelet, serum bilirubin

EpidemiologyMedicine
14
Article|14 citations·2022
Defining the learning curve for endotracheal intubation in the emergency department
Gun Tak Lee, Jong Eun Park, Sook‐Young Woo, Tae Gun Shin, Daun Jeong, Taerim Kim, Se Uk Lee, Hee Yoon, Sung Yeon Hwang
SJR Q1Scientific ReportsOA

To determine the minimum number of endotracheal intubation (ETI) attempts necessary for a novice emergency medicine (EM) trainee to become proficient with this procedure. This single-center study retrospectively analyzed data obtained from the institutional airway registry during the period from April 2014 to March 2021. All ETI attempts made by EM trainees starting their residency programs between 2014 and 2018 were evaluated. We used a first attempt success (FAS) rate of 85% as a proxy for ETI

Anesthesiology and Pain MedicineMedicine
15
Article|11 citations·2023
Prognostic Performance of Sequential Organ Failure Assessment, Acute Physiology and Chronic Health Evaluation III, and Simplified Acute Physiology Score II Scores in Patients with Suspected Infection According to Intensive Care Unit Type
Sung Yeon Hwang, In‐Kyu Kim, Daun Jeong, Jong-Eun Park, Gun Tak Lee, Junsang Yoo, Kihwan Choi, Tae Gun Shin, Kyuseok Kim
SJR Q1Journal of Clinical MedicineOA

We investigated the prognostic performance of scoring systems by the intensive care unit (ICU) type. This was a retrospective observational study using data from the Marketplace for Medical Information in the Intensive Care IV database. The primary outcome was in-hospital mortality. We obtained Sequential Organ Failure Assessment (SOFA), Acute Physiology and Chronic Health Evaluation (APACHE) III, and Simplified Acute Physiology Score (SAPS) II scores in each ICU type. Prognostic performance was

EpidemiologyMedicine

Research Areas

EpidemiologyEmergency MedicineCardiology and Cardiovascular MedicineCritical Care and Intensive Care MedicinePulmonary and Respiratory MedicineAnesthesiology and Pain Medicine

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