Si Hwan Jang
Yonsei University · Medicine
About the Lab
Professor Si Hwan Jang's research lab specializes in pulmonary fibrosis and regenerative medicine, focusing on developing novel nanotherapeutics for respiratory diseases. The lab investigates bone morphogenetic protein-7 (BMP-7) as a promising anti-fibrotic agent, particularly through innovative delivery systems like micelle nanoparticles for nasal inhalation. Utilizing advanced techniques such as single-cell RNA sequencing, the lab aims to decipher cellular mechanisms underlying lung fibrosis and evaluate therapeutic interventions at the molecular and cellular level. Their work bridges nanomedicine, respiratory pharmacology, and translational medicine to advance targeted therapies for fibrotic lung disorders.
Research Overview
Research Output Trend
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Selected Papers
2Abstract Background Bone morphogenetic protein-7 (BMP-7) antagonises transforming growth factor-β (TGF-β). This study investigated the ability of a prodrug BMP-7, designed as micelle nanoparticles for nasal inhalation, to ameliorate pulmonary fibrosis in a bleomycin (BLM)-induced murine model. Materials and Methods Fluorescently labelled BMP-7 was delivered to murine lungs via nasal inhalation. Thirty-eight C57BL/6J mice were divided into three groups: control, BLM and BLM with prodrug BMP-7. We
Research Areas
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