Soo Jin Park

BACKGROUND: The development and use of human embryonic stem cells (hESCs) in regenerative medicine have been revolutionary, offering significant advancements in treating various diseases. These pluripotent cells, derived from early human embryos, are central to modern biomedical research. However, their application is mired in ethical and regulatory complexities related to the use of human embryos. METHOD: This review utilized key databases such as ClinicalTrials.gov, EU Clinical Trials Register

Particulate matter (PM) exposure is related to an increased risk of sporadic Alzheimer's disease (AD), the pathogenesis of which is explained by chronic neurometabolic disturbance. Therefore, PM-induced alterations in neurometabolism might herald AD. We aimed to identify brain region-specific changes in metabolic pathways associated with ultrafine particle (UFP) exposure and to determine whether such metabolic alterations are linked to susceptibility to AD. We constructed UFP exposure chambers a

Despite the fact that endometriosis is a common gynecological disease that occurs in 10% of women of reproductive age, the pathogenesis and treatment strategy are not clear to date. Endometriosis patients are commonly characterized by adhesions in the pelvis or ovaries, which leads to prolonged inflammation in the abdominal cavity. To handle the chronic inflammation, changes of immune cells, including T cells, NK cells, and macrophage, are accompanied. Therefore, diverse cytokines and adhesions

CRIS identifier KCT0004605.

BACKGROUND: PHI-101 is an orally available, selective checkpoint kinase 2 (Chk2) inhibitor. PHI-101 has shown anti-tumour activity in ovarian cancer cell lines and impaired DNA repair pathways in preclinical experiments. Furthermore, the in vivo study suggests the synergistic effect of PHI-101 through combination with PARP inhibitors for ovarian cancer treatment. The primary objective of this study is to evaluate the safety and tolerability of PHI-101 in platinum-resistant recurrent ovarian canc

효율적인 국토환경관리와 지속가능한 생태자원의 보존을 위해서는 지형 및 토양의 공간적인 분포특성과 그것이 각종 자연 및 인문현상들과 가지는 상관성에 대한 이해가 선행되어야 한다. 기존의 지형분류법은 대부분 지형형성과정 혹은 지형의 단순한 형태분류에 치중하여, 분류 결과와 지표면에서 나타나는 다양한 생태학적 현상 들과의 관련성을 파악하기 어려운 단점이 있었다. 이 연구는 지표면에서 나타나는 물과 에너지, 그리고 물질의 흐름을 생태적 환경특성을 반영하는 주원인으로 규정하고, 이에 근거하여 전산화된 지형분류법을 개발하는 것을 목적으로 한다. 지표면을 에너지와 물질의 흐름을 반영하는 8개의 토양지형단위(soil landscape units)로 구분하였 으며, 이것을 수치고도모델(DEM)로부터 추출하는 방법을 개발하였다. 경기도 양평군의 약 12km2 크기의 지역에 개발된 기법을 적용하여 토양지형단위들을 분류한 뒤, 각 단위들의 공간적인 분포특성을 살펴보았다. 개발된 방 법은 일반적으로 구할

Acyl carrier protein (ACP) is a small acidic protein and its primary structure is highly conserved in various bacterial sources. Despite its small size, it interacts with diverse proteins associated with many biosynthetic pathways. The three-dimensional structure of H. pylori ACP and its structural characteristics were clarified using NMR and CD spectroscopy. H. pylori ACP consists of four helices connected by different sized loops. The helices correspond to residues L3-Q14 (alphaI), S36-G50 (al

≤ .05) in all regions except for bowels. In RIPAC, the pharmacokinetic properties reflected hemodynamic changes during capnoperitoneum, and there were no related toxicities. Conclusively, RIPAC may have the potential to enhance drug delivery into the peritoneum compared to PIPAC.

No visible tumor as the criterion for optimal cytoreduction was preferred in AOC, and aggressive surgery beyond conventional gynecological surgery tended to be performed by other surgeons. Moreover, the preference of neoadjuvant chemotherapy and the positive expectation of preoperative determination of optimal cytoreduction were higher in Europe than in USA.

BACKGROUND: The Laparoscopic Approach to Cervical Cancer trial and Surveillance, Epidemiology, and End Results program database study demonstrated that minimally invasive radical hysterectomy was inferior to abdominal radical hysterectomy in terms of disease recurrence and survival. Among risk factors related to poor prognosis after minimally invasive surgery (MIS), tumour spillage during intracorporeal colpotomy became a significant issue. Thus, we designed this trial to evaluate the efficacy a

BACKGROUND: Behçet's disease (BD) is a systemic inflammatory disease that involves various organs. The clinical manifestation-based diagnosis of BD is a time-consuming process, which makes it difficult to distinguish from patients with similar symptoms. Moreover, an authentic biomarker has not been developed for accurate diagnosis yet. Our current study investigated the unique metabolic signatures of BD and explored biomarkers for precise diagnosis based on an untargeted metabolomic approach. ME

현재 우리 사회에서 나타나고 있는 산맥에 관한 논란은 부분적으로는 산맥 표현에 대한 연구자 혹은 교과서 사이의 불일치, 그 리고 산맥의 설정 목적과 성인에 대한 지리학계의 불명확한 설명에서 그 원인을 찾을 수 있다. 이를 극복하기 위해서는 성인별로 분 류된 산맥을 설정 목적, 지도 축척, 그리고 교육 목적에 따라 계층적으로 제시하는 작업이 요구된다. 이 연구에서는 한반도의 복잡한 산지분포를 설명하는 개념을 산맥(mountain ranges)과 산줄기(mountain ridges)로 구분하여 사용할 것을 주장하였다. 새롭게 제안 하는 산맥도에서는 산지의 분포를 결정하는 지반운동과 삭박작용의 공간적인 특성을 적절하게 반영하고자 하였다. 그 결과 7개의 1 차 산맥과 8개의 2차 산맥 등 모두 15개의 산맥을 제안하였다. 새 산맥도에서는 기존의 산맥 중에서 적유령산맥, 묘향산맥, 멸악산 맥, 마식령산맥 등이 제외되었다. 제외된 산맥들은 모두 지표삭박작용이 강하게 작용하여 형성된 산지들로