Sun-A Lim
Ewha Womans University · Medicine
About the Lab
Professor Sun-A Lim's research lab focuses on the intersection of immunometabolism and cardiovascular disease, with a particular emphasis on understanding how metabolic reprogramming influences regulatory T cells in cancer immunity and the differential cardiovascular outcomes associated with thiazide diuretics. The lab investigates the metabolic adaptations of Tregs within the tumor microenvironment to uncover novel therapeutic targets for cancer immunotherapy, while also exploring the clinical implications of antihypertensive drug selection on long-term cardiovascular health. Current research directions include metabolic regulation of immune cell function and pharmacological outcomes in chronic disease.
Research Overview
Research Output Trend
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Selected Papers
2Regulatory T (Treg) cells are essential for maintaining immune homeostasis by suppressing excessive immune responses. In the context of cancer, however, Tregs promote immune evasion and tumor progression, particularly through their unique adaptations within the tumor microenvironment (TME). Recent research has emphasized how metabolic characteristics shape Treg activation, migration, and immunosuppressive function, revealing the impact of metabolic pathways on Treg fitness in homeostasis and wit
Abstract Background Chlorthalidone and hydrochlorothiazide are widely used thiazide diuretics for hypertension management. This study aimed to evaluate and compare the cardiovascular outcomes of patients treated with chlorthalidone versus hydrochlorothiazide. Methods This multicenter retrospective cohort study utilized data from our medical center, derived from electronic health records. A total of 14,257 hypertensive patients treated with either chlorthalidone (n = 1,920) or hydrochlorothiazide
Research Areas
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