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Sung-ah Bae

Yonsei University · Medicine

About the Lab

Professor Sung-ah Bae's research lab specializes in cardiovascular and molecular imaging, with a focus on developing and evaluating novel radiotracers for positron emission tomography (PET) to study serotonin transporters (SERT) and other monoamine transporters. The lab investigates the pathophysiological role of these transporters in cardiovascular and neuropsychiatric diseases, integrating preclinical imaging, in vitro binding assays, and clinical data to improve diagnostic accuracy and risk prediction. Recent work also explores the application of artificial intelligence, such as GPT-4, in enhancing cardiovascular disease risk prediction using large-scale population data.

PET imagingserotonin transportercardiovascular risk predictionradiotracer developmentartificial intelligence in medicine

Research Overview

Papers
68
Total Citations
883
Papers (5y)
51
Primary Field
Medicine

Research Output Trend

Figures are computed from collected data and may differ slightly.

Publications per year (5y)
51total
2022
2023
2024
2025
2026
Citations per year (5y)
249total
20222023202420252026

Selected Papers

15
1
Review|286 citations·2020
Impact of cardiovascular disease and risk factors on fatal outcomes in patients with COVID-19 according to age: a systematic review and meta-analysis
SungA Bae, So Ree Kim, Mi‐Na Kim, Wan Joo Shim, Seong‐Mi Park
SJR Q1HeartOA

OBJECTIVE: Previous studies that evaluated cardiovascular risk factors considered age as a potential confounder. We aimed to investigate the impact of cardiovascular disease (CVD) and its risk factors on fatal outcomes according to age in patients with COVID-19. METHODS: A systematic literature review and meta-analysis was performed on data collected from PubMed and Embase databases up to 11 June 2020. All observational studies (case series or cohort studies) that assessed in-hospital patients w

Infectious DiseasesMedicine
2
Article|142 citations·2002
Comparative Evaluation in Nonhuman Primates of Five PET Radiotracers for Imaging the Serotonin Transporters: [ 11 C]McN 5652, [ 11 C]ADAM, [ 11 C]DASB, [ 11 C]DAPA, and [ 11 C]AFM
Yiyun Huang, Dah‐Ren Hwang, Raj Narendran, Yasuhiko Sudo, Rano Chatterjee, SungA Bae, Osama Mawlawi, Lawrence S. Kegeles, Alan A. Wilson, Hank F. Kung, Marc Laruelle
SJR Q1Journal of Cerebral Blood Flow & MetabolismOA

The recent introduction of a number of new radiotracers suitable for imaging the serotonin transporters (SERT) has radically changed the field of SERT imaging. Whereas, until recently, only one selective SERT radiotracer was available ([11C]McN 5652) for SERT imaging with positron emission tomography (PET), several new C-11-labeled radiotracers of the -dimethyl-2-(arylthio)benzylamine class have been described as appropriate imaging agents for the SERT. The aim of this study was to conduct a com

Cellular and Molecular NeuroscienceNeuroscience
3
Article|63 citations·2005
Fluorinated Diaryl Sulfides as Serotonin Transporter Ligands: Synthesis, Structure−Activity Relationship Study, and in Vivo Evaluation of Fluorine-18-Labeled Compounds as PET Imaging Agents
Yiyun Huang, SungA Bae, Zhihong Zhu, Ningning Guo, Bryan L. Roth, Marc Laruelle
SJR Q1Journal of Medicinal ChemistryOA

A series of new, fluorine-containing substituted diphenyl sulfides was synthesized to serve as candidate ligands for positron emission tomography (PET) imaging of the serotonin transporter (SERT) and to further probe the structure-activity relationship (SAR) of this class of compounds. Candidate compounds were assayed for their affinities to the monoamine transporters (SERT, norepinephrine transporter (NET), and dopamine transporter (DAT)) in competitive binding experiments in vitro using cloned

Radiology, Nuclear Medicine and ImagingMedicine
4
Article|54 citations·2022
Clinical Outcomes in Patients With Delayed Hospitalization for Non–ST-Segment Elevation Myocardial Infarction
Jung‐Joon Cha, SungA Bae, Duk‐Woo Park, Jae Hyoung Park, Soon Jun Hong, Seong‐Mi Park, Cheol Woong Yu, Seung‐Woon Rha, Do‐Sun Lim, Soon Yong Suh, Seung Hwan Han, Seong‐Ill Woo
SJR Q1Journal of the American College of CardiologyOA
Cardiology and Cardiovascular MedicineMedicine
5
Article|34 citations·2024
Evaluation of GPT-4 for 10-year cardiovascular risk prediction: Insights from the UK Biobank and KoGES data
Changho Han, Dong Won Kim, Songsoo Kim, Seng Chan You, Jin Young Park, SungA Bae, Dukyong Yoon
SJR Q1iScienceOA

Cardiovascular disease (CVD) remains a pressing global health concern. While traditional risk prediction methods such as the Framingham and American College of Cardiology/American Heart Association (ACC/AHA) risk scores have been widely used in the practice, artificial intelligence (AI), especially GPT-4, offers new opportunities. Utilizing large scale of multi-center data from 47,468 UK Biobank participants and 5,718 KoGES participants, this study quantitatively evaluated the predictive capabil

Health InformaticsMedicine
6
Review|13 citations·2020
Efficacy and safety of drug-eluting stents in elderly patients: A meta-analysis of randomized trials
SungA Bae, Yongcheol Kim, Bill D. Gogas, Min Chul Kim, Doo Sun Sim, Young Joon Hong, Ju Han Kim, Youngkeun Ahn, Myung‐Ho Jeong
SJR Q2Cardiology JournalOA

This meta-analysis provides clinically relevant evidence that DES rather than BMS should be selected for elderly patients.

SurgeryMedicine
7
Article|11 citations·2023
Early Invasive Strategy Based on the Time of Symptom Onset of Non-ST-Segment Elevation Myocardial Infarction
SungA Bae, Jung‐Joon Cha, Subin Lim, Ju Hyeon Kim, Hyung Joon Joo, Jae Hyoung Park, Soon Jun Hong, Cheol Woong Yu, Do‐Sun Lim, Yongcheol Kim, Woong Chol Kang, Eun Jeong Cho
SJR Q1JACC: Cardiovascular InterventionsOA
Cardiology and Cardiovascular MedicineMedicine
8
Article|7 citations·2021
Usefulness of Diastolic Function Score as a Predictor of Long-Term Prognosis in Patients With Acute Myocardial Infarction
SungA Bae, Hyun Ju Yoon, Kye Hun Kim, Hyung Yoon Kim, Hyukjin Park, Jae Yeong Cho, Min Chul Kim, Yongcheol Kim, Youngkeun Ahn, Jeong Gwan Cho, Myung Ho Jeong
SJR Q1Frontiers in Cardiovascular MedicineOA

Background: Left ventricular diastolic function (LVDF) evaluation using a combination of several echocardiographic parameters is an important predictor of adverse events in patients with acute myocardial infarction (AMI). To date, the clinical impact of each individual LVDF marker is well-known, but the clinical significance of the sum of the abnormal diastolic function markers and the long-term clinical outcome are not well-known. This study aimed to investigate the usefulness of LVDF score in

Cardiology and Cardiovascular MedicineMedicine
9
Article|6 citations·2020
Clinical impact of echocardiography-defined pulmonary hypertension on the clinical outcome in patients with multiple myeloma
SungA Bae, Kye Hun Kim, Hyun Ju Yoon, Hyung Yoon Kim, Hyukjin Park, Jae Yeong Cho, Min Chul Kim, Yongcheol Kim, Young Joon Hong, Hyung Wook Park, Ju Han Kim, Youngkeun Ahn
SJR Q3MedicineOA

Pulmonary hypertension (PH) is a complication of multiple myeloma (MM); however, the clinical outcomes and prognosis are relatively not well known. We aimed to investigate the risk factors of transthoracic echocardiography-defined PH and its impact on the clinical outcome in patients with MM.A retrospective study was performed using data from the Chonnam National University Hwasun Hospital database for patients who underwent transthoracic echocardiography (TTE) within 1 month of the MM diagnosis

Pulmonary and Respiratory MedicineMedicine
10
Article|6 citations·2024
Early menopause is associated with abnormal diastolic function and poor clinical outcomes in women with suspected angina
SungA Bae, Seong‐Mi Park, So Ree Kim, Mi‐Na Kim, Dong‐Hyuk Cho, Hee‐Dong Kim, Hyun Ju Yoon, Myung‐A Kim, Hack‐Lyoung Kim, Kyung-Soon Hong, Mi‐Seung Shin, Jin‐Ok Jeong
SJR Q1Scientific ReportsOA

Early identification of women at high risk for cardiovascular diseases (CVD), with subsequent monitoring, will allow for improved clinical outcomes and generally better quality of life. This study aimed to identify the associations between early menopause, abnormal diastolic function, and clinical outcomes. This retrospective study included 795 menopausal women from is a nationwide, multicenter, registry of patients with suspected angina visiting outpatient clinic. The patients into two groups:

Endocrinology, Diabetes and MetabolismMedicine
11
Preprint|5 citations·2023
Large-language-model-based 10-year risk prediction of cardiovascular disease: insight from the UK biobank data
Changho Han, Dong Won Kim, Songsoo Kim, Seng Chan You, SungA Bae, Dukyong Yoon
medRxivOA

Abstract Background Conventional cardiovascular risk prediction models provide insights into population-level risk factors and have been widely adopted in clinical practice. However, these models have limited generalizability and flexibility. Large language models (LLMs) have demonstrated remarkable proficiency for use in various industries. Methods In this study, we have investigated the feasibility of Large Language Models (LLMs) such as ChatGPT-3.5, ChatGPT-4, and Bard for predicting 10-year

Health InformaticsMedicine
12
Article|3 citations·2023
Impact of amlodipine on clinical outcomes for heart failure in patients with dilated cardiomyopathy: a Korean nationwide cohort study
SungA Bae, Wan Kee Kim, Seng Chan You, Minkwan Kim, In Hyun Jung
SJR Q1Frontiers in Cardiovascular MedicineOA

Introduction Amlodipine, widely used as a first-line treatment for hypertension, has inconclusive clinical evidence regarding its efficacy in patients with heart failure. This retrospective cohort study aimed to investigate the clinical effectiveness of amlodipine treatment after hospitalization for heart failure in patients with dilated cardiomyopathy (DCMP). Methods A total of 20,851 patients who were diagnosed with DCMP and admitted for heart failure between 2005 and 2016 according to Korean

Cardiology and Cardiovascular MedicineMedicine
13
Article|2 citations·2021
The Influence of Mother's Parenting Beliefs and Parenting Behaviors on Children's Self-regulation and Social Leadership and Mediating Effect of Parenting Behavior
SungA Bae, Hye‐Jeong Choi
Korean Association For Learner-Centered Curriculum And Instruction

목적 본 연구는 어머니의 양육신념과 양육행동이 유아의 자기조절력과 유아 리더십에 영향요인인가를 파악하고 어머니 양육행동의 매개효과를 검정하여 그 중요성과 시사점을 제시하기 위한 것이다. 방법 이를 위해서 4곳의 유아기관으로부터 어머니와 유아를 통하여 2016년 5월 23일부터 6월 10일까지 516부의 자료 연구를 표집하였으며, 회귀분석 및 상관분석과 중다회귀분석을 실시하였다. 결과 이에 대한 결과는 다음과 같다. 첫째, 어머니 양육신념이 유아의 자기조절력에 미치는 영향에서 인성강조는 정서조절에, 지적성취는 행동조절에 유의한 것으로 예측되었다. 또한 환경주의는 행동조절 및 정서조절에 모두 유의미하였다. 둘째, 어머니 양육신념이 유아의 사회적 리더십에 미치는 영향에서는 인성강조는 공동체배려에, 지적성취는 타인존중, 환경주의는 타인존중과 공동체 배려 모두에 유의미한 영향을 미쳤다. 셋째, 어머니 양육행동이 유아 자기조절력에 미치는 영향에서 온정⋅격려는 행동조절에 유의하였다. 과보호⋅허용

Sociology and Political ScienceSocial Sciences
14
Preprint|1 citations·2025
Comparative Analysis of Multimodal Large Language Models GPT-4o and o1 vs Clinicians in Clinical Case Challenge Questions
Jaewon Jung, Hyunjae Kim, SungA Bae, Jin Young Park
medRxivOA

SUMMARY Background Generative Pre-trained Transformer 4 (GPT-4) has demonstrated strong performance in standardized medical examinations but has limitations in real-world clinical settings. The newly released multimodal GPT-4o model, which integrates text and image inputs to enhance diagnostic capabilities, and the multimodal o1 model, which incorporates advanced reasoning, may address these limitations. Objective This study aimed to compare the performance of GPT-4o and o1 against clinicians in

Health InformaticsMedicine
15
Article|1 citations·2025
Effectiveness and Safety of Very-Low-Dose Rosuvastatin–Ezetimibe Therapy in Korean Patients with Dyslipidaemia: A Multicentre Prospective Observational Study
Ji Woong Roh, Moon-Hwa Park, Ji‐Won Son, SungA Bae, the HM-ROS-OS-2102 Study Investigator Group
SJR Q2Clinical Drug Investigation
SurgeryMedicine

Research Areas

Cardiology and Cardiovascular MedicineSurgeryHealth InformaticsRadiology, Nuclear Medicine and ImagingEndocrinology, Diabetes and MetabolismMolecular Biology

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