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Sung-gwan Shin

Yonsei University · Medicine

About the Lab

Professor Sung-gwan Shin's research lab specializes in gastrointestinal oncology and endoscopic therapeutics, with a focus on early-stage gastrointestinal cancers, particularly rectal and gastric carcinoids, esophageal cancer, and microsatellite instability-high (MSI-H) gastric cancers. The lab investigates prognostic factors, endoscopic resection outcomes, and novel therapeutic strategies such as polaprezinc for ulcer healing after endoscopic submucosal dissection. It also explores viral oncomarkers, including JC virus, in gastrointestinal carcinogenesis. The research integrates clinical pathology with translational insights to improve diagnosis, treatment, and prognosis in GI malignancies.

endoscopic resectiongastric cancermicrosatellite instabilityesophageal cancerulcer healing

Research Overview

Papers
322
Total Citations
4,565
Papers (5y)
35
Primary Field
Medicine

Research Output Trend

Figures are computed from collected data and may differ slightly.

Publications per year (5y)
35total
2022
2023
2024
2025
2026
Citations per year (5y)
62total
20222023202420252026

Selected Papers

15
1
Article|136 citations·2011
Criteria for decision making after endoscopic resection of well-differentiated rectal carcinoids with regard to potential lymphatic spread
Chulmin Park, Jae Hee Cheon, J. Kim, Jongbeom Shin, Byung-Ik Jang, Sung Kwan Shin, Y.T. Jeen, Soo Hyun Lee, Jun Ji, Dong Soo Han, Sung-Ae Jung, Dong Il Park
SJR Q1EndoscopyOA

Endoscopic resection is a safe and effective modality for treating well-differentiated rectal carcinoids smaller than 10 mm in diameter. Discrepancies were observed between CR-E and CR-P. The risk factors for metastasis were tumor size, increased mitotic rate, and lymphovascular invasion.

EpidemiologyMedicine
2
Article|132 citations·2008
Mutations in Both KRAS and BRAF May Contribute to the Methylator Phenotype in Colon Cancer
Takeshi Nagasaka, Minoru Koi, Matthias Kloor, Johannes Gebert, Alex Vilkin, Naoshi Nishida, Sung Kwan Shin, Hiromi Sasamoto, Noriaki Tanaka, Nagahide Matsubara, C. Richard Boland, Ajay Goel
SJR Q1GastroenterologyOA
Pathology and Forensic MedicineMedicine
3
Article|120 citations·2014
Pre-treatment neutrophil to lymphocyte ratio as a prognostic marker to predict chemotherapeutic response and survival outcomes in metastatic advanced gastric cancer
In Rae Cho, Jun Chul Park, Chan Hyuk Park, Jung Hyun Jo, Hyun Jik Lee, Sunyong Kim, Choong Nam Shim, Hyuk Lee, Sung Kwan Shin, Sang Kil Lee, Yong Chan Lee
SJR Q1Gastric CancerOA
OncologyMedicine
4
Article|106 citations·2007
Epigenetic and Genetic Alterations in Netrin-1 Receptors UNC5C and DCC in Human Colon Cancer
Sung Kwan Shin, Takeshi Nagasaka, Barbara Jung, Nagahide Matsubara, Won Ho Kim, John M. Carethers, C. Richard Boland, Ajay Goel
SJR Q1GastroenterologyOA
Cellular and Molecular NeuroscienceNeuroscience
5
Article|104 citations·2006
Association of JC Virus T-Antigen Expression With the Methylator Phenotype in Sporadic Colorectal Cancers
Ajay Goel, Mei‐Shu Li, Takeshi Nagasaka, Sung Kwan Shin, Florentine Fuerst, Luigi Ricciardiello, L Wasserman, C. Richard Boland
SJR Q1GastroenterologyOA
OncologyMedicine
6
Article|101 citations·2017
Comparative study between endoscopic submucosal dissection and surgery in patients with early gastric cancer
Kyu Yeon Hahn, Chan Hyuk Park, Yong Kang Lee, Hyunsoo Chung, Jun Chul Park, Sung Kwan Shin, Yong Chan Lee, Hyoung‐Il Kim, Jae‐Ho Cheong, Woo Jin Hyung, Sung Hoon Noh, Sang Kil Lee
SJR Q1Surgical EndoscopyOA
Pulmonary and Respiratory MedicineMedicine
7
Article|101 citations·2014
Clinical safety of endoscopic submucosal dissection compared with surgery in elderly patients with early gastric cancer: a propensity-matched analysis
Chan Hyuk Park, Hyuk Lee, Dong Wook Kim, Hyunsoo Chung, Jun Chul Park, Sung Kwan Shin, Woo Jin Hyung, Sang Kil Lee, Yong Chan Lee, Sung Hoon Noh
SJR Q1Gastrointestinal Endoscopy
Pulmonary and Respiratory MedicineMedicine
8
Review|97 citations·2014
Lymph Node Metastases in Esophageal Carcinoma: An Endoscopist's View
Jin Woong Cho, Suck Chei Choi, Jae Young Jang, Sung Kwan Shin, Kee Don Choi, Jun Haeng Lee, Sang Gyun Kim, Jae Kyu Sung, Seong Woo Jeon, Il Ju Choi, Gwang Ha Kim, Sam Ryong Jee
SJR Q2Clinical EndoscopyOA

One of the most important prognostic factors in esophageal carcinoma is lymph node metastasis, and in particular, the number of affected lymph nodes, which influences long-term outcomes. The esophageal lymphatic system is connected longitudinally and transversally; thus, the pattern of lymph node metastases is very complex. Early esophageal cancer frequently exhibits skipped metastasis, and minimal surgery using sentinel node navigation cannot be performed. In Korea, most esophageal cancer cases

SurgeryMedicine
9
Article|96 citations·2010
Histologic diagnosis based on forceps biopsy is not adequate for determining endoscopic treatment of gastric adenomatous lesions
Yu Jin Kim, Jun Chul Park, Jie‐Hyun Kim, Sung Kwan Shin, Sang Kil Lee, Yong Chan Lee, Joonho Chung
SJR Q1EndoscopyOA

We should consider endoscopic resection for gastric LGD that are 2 cm or more in size and do not have whitish discoloration.

Pulmonary and Respiratory MedicineMedicine
10
Article|88 citations·2013
Long-term outcome of early gastric cancer after endoscopic submucosal dissection: Expanded indication is comparable to absolute indication
Chan Hyuk Park, Suji Shin, Jun Chul Park, Sung Kwan Shin, Sang Kil Lee, Yong Chan Lee, Hyuk Lee
SJR Q1Digestive and Liver DiseaseOA
Pulmonary and Respiratory MedicineMedicine
11
Article|85 citations·2010
Predictive factors for local recurrence after endoscopic resection for early gastric cancer: long-term clinical outcome in a single-center experience
Jun Chul Park, Sang Kil Lee, Ju Hee Seo, Yu Jin Kim, Hyunsoo Chung, Sung Kwan Shin, Yong Chan Lee
SJR Q1Surgical EndoscopyOA
Pulmonary and Respiratory MedicineMedicine
12
Article|77 citations·2010
High microsatellite instability predicts good prognosis in intestinal‐type gastric cancers
Hyunki Kim, Hyunki Kim, Ji Yeong An, Sung Hoon Noh, Sung Kwan Shin, Yong Chan Lee, Hoguen Kim, Hoguen Kim
SJR Q1Journal of Gastroenterology and HepatologyOA

BACKGROUND AND AIM: A subset of gastric cancers showed high microsatellite instability (MSI-H). The reported clinicopathological features of MSI-H gastric cancers are heterogeneous, and specific factors associated with prognosis have not been identified. METHODS: We analyzed the clinicopathological characteristics and prognostic factors in a large series (161 cases) of MSI-H gastric cancers, and compared the results to 315 cases of microsatellite-stable or low microsatellite-instable gastric can

Pathology and Forensic MedicineMedicine
13
Article|66 citations·2006
Oncogenic T‐antigen of JC virus is present frequently in human gastric cancers
Sung Kwan Shin, Mei‐Shu Li, Florentine Fuerst, Erin Hotchkiss, Richard L. Meyer, Tae Il Kim, Ajay Goel, C. Richard Boland
SJR Q1CancerOA

BACKGROUND: JC virus (JCV) is a polyomavirus that commonly infects humans and is the causative agent of progressive multifocal leukoencephalopathy in immune-compromised patients. An association between JCV and human cancers long has been suspected, because this virus induces brain tumors in several animal models. The oncogenic potential of JCV is mediated by a transforming protein, the T-antigen (T-Ag), which is a multifunctional protein that transforms cells through interactions with various gr

OncologyMedicine
14
Article|15 citations·2018
Comparison of long-term clinical outcomes between endoscopic and surgical resection for early-stage adenocarcinoma of the esophagogastric junction
Hyun Ju Kim, Hyunsoo Chung, Sung Kwan Shin, Hyoung‐Il Kim, Jun Chul Park, Sang Kil Lee, Woo Jin Hyung, Yong Chan Lee, Sung Hoon Noh
SJR Q1Surgical EndoscopyOA
Pulmonary and Respiratory MedicineMedicine
15
Article|12 citations·2020
Comparison of the Efficacy of Polaprezinc Plus Proton Pump Inhibitor and Rebamipide Plus Proton Pump Inhibitor Treatments for Endoscopic Submucosal Dissection-induced Ulcers
Da Hyun Jung, Jun Chul Park, Yong Chan Lee, Sang Kil Lee, Sung Kwan Shin, Hyunsoo Chung, Jae Jun Park, Jie‐Hyun Kim, Young Hoon Youn, Hyojin Park
SJR Q2Journal of Clinical GastroenterologyOA

GOALS: We assessed the efficacy of polaprezinc plus proton pump inhibitor (PPI) treatment for endoscopic submucosal dissection (ESD)-induced ulcer healing compared with rebamipide plus PPI treatment. BACKGROUND: ESD has been widely used as a local treatment option that cures gastric neoplasms. However, it causes large and deep artificial ulcers, and there are no guidelines with regard to the optimal treatment durations and drug regimens for ESD-induced ulcers. Polaprezinc is effective for promot

Pulmonary and Respiratory MedicineMedicine

Research Areas

Pulmonary and Respiratory MedicineSurgeryGastroenterologyOncologyPathology and Forensic MedicineEndocrinology, Diabetes and Metabolism

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