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Sung-Hwan Han

Yonsei University · Medicine

About the Lab

Professor Sung-Hwan Han's research lab specializes in orthopedic regenerative medicine, with a primary focus on cartilage and tendon repair using biological and tissue engineering approaches. The lab investigates the use of mesenchymal stem cells, growth factors like TGF-β3, and biodegradable scaffolds such as PLGA for osteochondral defect regeneration. It also explores the biological effects of extracorporeal shock wave therapy on tendon tissue, aiming to modulate inflammatory responses and promote healing. Additionally, the lab conducts clinical and radiological studies to evaluate diagnostic accuracy and long-term outcomes in ankle pathologies, including syndesmotic injuries and subchondral cysts.

cartilage regenerationtendon repairshock wave therapymesenchymal stem cellsosteochondral defects

Research Overview

Papers
138
Total Citations
2,494
Papers (5y)
28
Primary Field
Medicine

Research Output Trend

Figures are computed from collected data and may differ slightly.

Publications per year (5y)
28total
2022
2023
2024
2025
2026
Citations per year (5y)
100total
20222023202420252026

Selected Papers

15
1
Article|167 citations·2007
Chronic Tibiofibular Syndesmosis Injury: The Diagnostic Efficiency of Magnetic Resonance Imaging and Comparative Analysis of Operative Treatment
Seung Hwan Han, Jin Woo Lee, Sung Jun Kim, Jin‐Suck Suh, Yoon Rak Choi
SJR Q1Foot & Ankle InternationalOA

BACKGROUND: The purpose of this study was to determine the sensitivity and specificity of MRI in chronic syndesmosis injury by comparing the arthroscopic findings with MRI findings and to suggest therapeutic guidelines of syndesmotic fixation. METHODS: Between January, 2003, and January, 2004, 20 patients were diagnosed with chronic syndesmosis injury according to syndesmosis widening (>2 mm) on arthroscopic examination. The average age of the patients was 32 years. The minimum followup was 22 (

Orthopedics and Sports MedicineMedicine
2
Article|98 citations·2006
Radiographic Changes and Clinical Results of Osteochondral Defects of the Talus with and without Subchondral Cysts
Seung Hwan Han, Jin Woo Lee, Dae Young Lee, Eung Shick Kang
SJR Q1Foot & Ankle InternationalOA

BACKGROUND: Subchondral cysts are a type of osteochondral defect of the talus and can be a source of chronic ankle pain. The treatment modality of this cystic lesion is similar to that of other osteochondral defects, but results from previous reports are controversial. Therefore, we compared the clinical results and radiographic changes in small subchondral talar cystic lesions (less than 1.5 cm2) to other noncystic defects after arthroscopic operations without bone grafting. METHODS: The review

Orthopedics and Sports MedicineMedicine
3
Article|70 citations·2009
J. Leonard Goldner Award 2008: Effect of Extracorporeal Shock Wave Therapy on Cultured Tenocytes
Seung Hwan Han, Jin Woo Lee, Gregory P. Guyton, Brent G. Parks, Jean-Paul Courneya, Lew C. Schon
SJR Q1Foot & Ankle International

BACKGROUND: Little has been reported about the biologic effect of shock waves on human normal or pathologic tendon tissue. We hypothesized that inflammatory cytokine and MMP production would be down-regulated by shock wave stimulation. MATERIALS AND METHODS: Diseased Achilles tendon tissue and healthy flexor hallucis longus tissue were used. Shock wave treatment was applied to cultured cells at 0.17 mJ/mm(2)energy 250, 500, 1000, and 2000 times. RESULTS: A dose-dependent decrease in cell viabili

Orthopedics and Sports MedicineMedicine
4
Article|65 citations·2008
Histological and biomechanical properties of regenerated articular cartilage using chondrogenic bone marrow stromal cells with a PLGA scaffold in vivo
Seung Hwan Han, Yoon Hee Kim, Min Sung Park, In Ae Kim, Jung Woog Shin, Woo Ick Yang, Kyoung Soo Jee, Ki Dong Park, Gyu Ha Ryu, Jin Woo Lee
SJR Q1Journal of Biomedical Materials Research Part AOA

The properties of regenerated cartilage using bone marrow-derived mesenchymal stem cells (MSCs) and poly lactic-co-glycolic acid (PLGA) scaffold composites pretreated with TGF-beta3 were investigated and compared to the non-TGF-beta3 treated MSCs/PLGA composites in a rabbit model. We prepared MSCs/PLGA scaffold composites and pretreated it with TGF-beta3 for 3 weeks prior to transplantation. Then, composites were transplanted to the osteochondral defect in the rabbit knee. After 12 weeks of tran

RheumatologyMedicine
5
Article|49 citations·2009
Effect of Extracorporeal Shock Wave Therapy on Cultured Tenocytes
Seung Hwan Han, Jin Woo Lee, Gregory P. Guyton, Brent G. Parks, Jean-Paul Courneya, Lew C. Schon
SJR Q1Foot & Ankle InternationalOA

BACKGROUND: Little has been reported about the biologic effect of shock waves on human normal or pathologic tendon tissue. We hypothesized that inflammatory cytokine and MMP production would be down-regulated by shock wave stimulation.\n\nMATERIALS AND METHODS: Diseased Achilles tendon tissue and healthy flexor hallucis longus tissue were used. Shock wave treatment was applied to cultured cells at 0.17 mJ/mm(2)energy 250, 500, 1000, and 2000 times.\n\nRESULTS: A dose-dependent decrease in cell v

Orthopedics and Sports MedicineMedicine
6
Article|45 citations·2019
Collagen dressing in the treatment of diabetic foot ulcer: A prospective, randomized, placebo-controlled, single-center study
Kwang Hwan Park, Jae Bum Kwon, Jae Han Park, Ju Cheol Shin, Seung Hwan Han, Jin Woo Lee
SJR Q1Diabetes Research and Clinical PracticeOA
Endocrinology, Diabetes and MetabolismMedicine
7
Article|44 citations·2021
Bone Marrow Stimulation for Osteochondral Lesions of the Talus: Are Clinical Outcomes Maintained 10 Years Later?
Jae Han Park, Kwang Hwan Park, Jae‐Yong Cho, Seung Hwan Han, Jin Woo Lee
SJR Q1The American Journal of Sports MedicineOA

Background: Arthroscopic bone marrow stimulation (BMS) is considered the first-line treatment for osteochondral lesions of the talus (OLTs). However, the long-term stability of the clinical success of BMS remains unclear. Purpose: To investigate the long-term clinical outcomes among patients who underwent BMS for OLT and to identify prognostic factors for the need for revision surgery. Study Design: Case series; Level of evidence, 4. Methods: A retrospective analysis was performed on 202 ankles

Orthopedics and Sports MedicineMedicine
8
Article|39 citations·2008
Ossicles associated with chronic pain around the malleoli of the ankle
Seung Hwan Han, Woo Jin Choi, Su Ram Kim, Sung‐Jae Kim, Jin Woo Lee
Journal of Bone and Joint Surgery - British VolumeOA

We undertook a retrospective review of 24 arthroscopic procedures in patients with symptomatic ossicles around the malleoli of the ankle. Most of the patients had a history of injury and localised tenderness in the area coinciding with the radiological findings. Contrast-enhanced three-dimensional fast-spoiled gradient-echo MRI was performed and the results compared with the arthroscopic findings. An enhanced signal surrounding soft tissue corresponding to synovial inflammation and impingement w

Orthopedics and Sports MedicineMedicine
9
Article|35 citations·2019
Quantitative analysis of the bilateral coordination and gait asymmetry using inertial measurement unit-based gait analysis
Seung Hwan Han, Chang Oh Kim, Kwang Joon Kim, Jeanhong Jeon, Hsien-Hao Chang, Eun Seo Kim, Hoon Park
SJR Q1PLoS ONEOA

Inertial measurement unit (IMU)-based gait analysis can be used to quantitatively analyze the bilateral coordination and gait asymmetry (GA). The purpose of this study was to investigate changes in bilateral coordination and GA due to gait speed using an IMU based gait analysis and identify spatiotemporal factors affecting bilateral coordination and GA. Eighty healthy adults (40 men and 40 women) participated in the study. The mean age was 26.2 years, and the mean body mass index was 22.8 kg/m2.

Physical Therapy, Sports Therapy and RehabilitationHealth Professions
10
Article|34 citations·2020
Primary Autologous Osteochondral Transfer Shows Superior Long‐Term Outcome and Survival Rate Compared With Bone Marrow Stimulation for Large Cystic Osteochondral Lesion of Talus
Dong Woo Shim, Kwang Hwan Park, Jin Woo Lee, Yun-Jung Yang, Jucheol Shin, Seung Hwan Han
SJR Q1Arthroscopy The Journal of Arthroscopic and Related SurgeryOA

PURPOSE: To compare the results of bone marrow stimulation (BMS) versus autologous osteochondral transfer (AOT) as primary surgical option for large cystic osteochondral lesion of talus (OLT) and to further distinguish factors associated with clinical failures and overall survival. METHODS: ) who underwent either primary BMS or AOT between January 2001 and January 2016 with a minimum follow-up of 36 months. Lesion surface area and volume were measured on magnetic resonance imaging. Clinical outc

Orthopedics and Sports MedicineMedicine
11
Article|25 citations·2011
Is the Anterior Tibial Artery Safe During Ankle Arthroscopy?
Kwang-Hyun Son, Jaeho Cho, Jin Woo Lee, Kyu‐Sung Kwack, Seung Hwan Han
SJR Q1The American Journal of Sports Medicine

BACKGROUND: Pseudoaneurysm of the anterior tibial artery (ATA) after ankle arthroscopy is an uncommon complication but can cause unexpected consequences. However, its contributing factor is not fully understood. HYPOTHESIS: Anatomic factors, such as ATA variations and the distance between the ATA and joint capsule, may contribute to the occurrence of pseudoaneurysm. STUDY DESIGN: Case series; Level of evidence, 4. METHODS: The magnetic resonance images and medical records of 358 ankle cases were

Pulmonary and Respiratory MedicineMedicine
12
Article|24 citations·2014
Prognostic Factors after Intra-Articular Hyaluronic Acid Injection in Ankle Osteoarthritis
Seung Hwan Han, Do Young Park, Tae Hun Kim
SJR Q2Yonsei Medical JournalOA

While hyaluronic acid injection for ankle osteoarthritis is a safe and effective treatment, careful selection of patients should be made according to the above prognostic predictors.

RheumatologyMedicine
13
Article|14 citations·2019
Allogeneic keratinocyte for intractable chronic diabetic foot ulcers: A prospective observational study
Yeok Gu Hwang, Jin Woo Lee, Kwang Hwan Park, Seung Hwan Han
SJR Q1International Wound JournalOA

Chronic diabetic foot ulcers (DFUs) are a common problem in patients with diabetes and are often difficult to treat. The application of newly developed dressing material in patients with chronic DFUs has been reported to be effective. The purpose of this study was to evaluate the usefulness of allogeneic keratinocyte treatment for chronic DFUs. We performed weekly allogeneic keratinocyte treatment for up to 12 weeks in 71 patients with intractable DFUs. We investigated healing rate, wound-healin

Endocrinology, Diabetes and MetabolismMedicine
14
Article|10 citations·2017
Posterior Fibular Groove Deepening Procedure With Low-Profile Screw Fixation of Fibrocartilaginous Flap for Chronic Peroneal Tendon Dislocation
Jae Wan Suh, Jin Woo Lee, Jun Yong Park, Woo Jin Choi, Seung Hwan Han
SJR Q2The Journal of Foot & Ankle SurgeryOA
Orthopedics and Sports MedicineMedicine
15
Article|9 citations·2015
First Metatarsal Proximal Opening Wedge Osteotomy for Correction of Hallux Valgus Deformity: Comparison of Straight versus Oblique Osteotomy
Seung Hwan Han, Eui Hyun Park, Joon Jo, Yong Gon Koh, Jin Woo Lee, Woo Jin Choi, Yong Sang Kim
SJR Q2Yonsei Medical JournalOA

Compared with a straight first metatarsal osteotomy, an oblique first metatarsal osteotomy yielded better clinical and radiological outcomes.

Orthopedics and Sports MedicineMedicine

Research Areas

Orthopedics and Sports MedicineSurgeryEndocrinology, Diabetes and MetabolismRheumatologyCardiology and Cardiovascular MedicineCivil and Structural Engineering

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