Sung-Joon Park

Resveratrol, a polyphenol in red wine, has been reported as a calorie restriction mimetic with potential antiaging and antidiabetogenic properties. It is widely consumed as a nutritional supplement, but its mechanism of action remains a mystery. Here, we report that the metabolic effects of resveratrol result from competitive inhibition of cAMP-degrading phosphodiesterases, leading to elevated cAMP levels. The resulting activation of Epac1, a cAMP effector protein, increases intracellular Ca(2+)

Abstract High-affinity antibody production through the germinal centre (GC) response is a pivotal process in adaptive immunity. Abnormal development of follicular helper T (T FH ) cells can induce the GC response to self-antigens, subsequently leading to autoimmunity. Here we show the transcriptional repressor Capicua/CIC maintains peripheral immune tolerance by suppressing aberrant activation of adaptive immunity. CIC deficiency induces excessive development of T FH cells and GC responses in a

The specific Sirt1 activator SRT1720 increases mitochondrial function in skeletal muscle, presumably by activating Sirt1. However, Sirt1 gain of function does not increase mitochondrial function, which raises a question about the central role of Sirt1 in SRT1720 action. Moreover, it is believed that the metabolic effects of SRT1720 occur independently of AMP-activated protein kinase (AMPK), an important metabolic regulator that increases mitochondrial function. Here, we show that SRT1720 activat

Liver‐resident memory T (liver T RM ) cells exert protective immune responses following liver infection by malaria parasites. However, how these T RM cells are developed and what the consequence is if they are not properly maintained remain poorly understood. Here, we show that the transcriptional repressor, Capicua (CIC), controls liver CD8 + T RM cell development to maintain normal liver function. Cic ‐deficient mice have a greater number of liver CD8 + T RM cells and liver injury phenotypes a

BACKGROUND: A favorable neurological outcome is closely related to patient characteristics and total cardiopulmonary resuscitation (CPR) duration. The total CPR duration consists of pre-hospital and in-hospital durations. To date, consensus is lacking on the optimal total CPR duration. Therefore, this study aimed to determine the upper limit of total CPR duration, the optimal cut-off time at the pre-hospital level, and the time to switch from conventional CPR to alternative CPR such as extracorp

Smart-home technology and related services can reinforce a person’s experiential nature, promoting sustainable living among the elderly. It is crucial in the housing industry that support “Aging in Place”, contributing to the contact, control, and simulation of nature at home as well as the creation of a high-quality living space instead of mechanical achievement. Further, biophilic experience, the strengthening of inherent human propensity to nature for optimal health and well-being, supports t

This study covers the issue of insufficient childcare support, which is part of the combined social problem of low birth rates and aging, and sets the direction for the environmental improvement of childcare facilities. This study aims to find the clues to creating an optimized environment for children in nature, which is a key factor that generally promotes children’s physical, cognitive, and social development. In this paper, we conducted a literature review and case study to determine the spa

An osteoma of the temporal bone is a rare benign tumor. External auditory canal is the most common site of osteomas arising from temporal bone, and mastoid osteoma is very rare. A case of a 42-year-old female with a huge osteoma which developed from mastoid cortical bone is presented and the review of the temporal bone osteomas is discussed. The patient showed a huge and hard mass in the right mastoid area growing over a 20-year period. A temporal bone computed tomography scan demonstrated 2.3×2