Tae Hee Oh
Sungkyunkwan University · Medicine
About the Lab
Professor Tae Hee Oh's research lab focuses on neurotrophic factors and their role in neuromuscular regulation, particularly the molecular mechanisms underlying muscle maintenance and acetylcholinesterase regulation. The lab investigates trophic proteins such as sciatin, isolated from peripheral nerves, to understand their influence on muscle function and survival in both embryonic and denervated adult muscle cultures. The research also extends into clinical applications, including the evaluation of surgical outcomes in cardiac valve surgery and minimally invasive surgical techniques, reflecting a translational approach from basic neurobiology to clinical surgery. The lab integrates cell biology, immunohistochemistry, and clinical data analysis to explore nerve-muscle interactions and surgical innovation.
Research Overview
Research Output Trend
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Selected Papers
15Acetylcholinesterase activity in cultures of dissociated skeletal muscle prepared from the thigh muscle of the 10-day-old chick embryo was increased by the presence of innervating spinal cord explants, spinal cord explants in a parabiotic environment, and by media containing brain-spinal cord extract.
Acute epiglottitis is a life-threatening respiratory emergency of early childhood. The disease may progress so rapidly that complete upper airway obstruction occurs within hours.1 Trachostomy has been the procedure of choice2–4 to relieve airway obstruction; however, in recent years several investigators have reported the encouraging results of nasotracheal intubation5–12 as an alternate procedure in the management of acute epiglottitis. The purpose of this report is to evaluate the relative eff
Skeletal muscles lose acetylcholinesterase in culture as a result of denervation. A protein fraction isolated from peripheral nerves maintained the level of acetylcholinesterase in cultures of aneural embryonic muscle or denervated adult chicken muscle. These results indicate that trophic regulation of muscle acetylcholinesterase might be mediated by a protein produced by nerves.
A mytotrophic protein (sciatin) purified from chicken sciatic nerves has "trophic" or "maintenance" effects on cultured muscle. We have elicited a specific antiserum against purified sciatin in rabbits. Using this antiserum, we investigated the distribution of sciatin in embryonic and adult chicken tissues by an unlabeled peroxidase-an-tiperoxidase method at the light microscopic level. The antiserum stained adult chicken neural tissues in situ and cultured embryonic chick neurons. Staining was
OBJECTIVES: Isolated tricuspid valve surgery is not commonly performed with few studies and limited numbers published. We reviewed the characteristics and outcomes, including survival, reoperation rates and their predictors of different types of isolated tricuspid surgery. METHODS: Patients coded for isolated tricuspid valve surgery were identified from the Green Lane Hospital database. Relevant clinical characteristics were collected from both clinical and written clinical records. Mortality wa
Since the introduction of laparoscopic surgery, the promise of lower postoperative morbidity and improved cosmesis has been achieved. Laparoendoscopic single-site surgery (LESS) potentially takes this further. Following the first human urological LESS report in 2007, numerous case series have emerged, as well as comparative studies comparing LESS with standard laparoscopy. However, comparative series between conventional laparoscopy and LESS for different procedures suggest a non-inferiority of
To investigate whether immunocytochemical localization of muscle-specific aldolase can be used for fiber phenotype determination, we produced specific antibodies against the enzyme and studied its distribution in adult chicken skeletal muscles by indirect immunofluorescence microscopy. Monoclonal antibodies against the myosin heavy chains of fast-twitch (MF-14) and slow-tonic (ALD-58) muscle fibers were also used to correlate aldolase levels with the fiber phenotype. The goat anti-aldolase antib
Since the introduction of laparoscopic surgery, the promise of lower postoperative morbidity and improved cosmesis has been achieved. Laparoendoscopic single-site surgery (LESS) potentially takes this further. Following the first human urological LESS report in 2007, numerous case series have emerged, as well as comparative studies comparing LESS with standard laparoscopy. However, comparative series between conventional laparoscopy and LESS for different procedures suggest a non-inferiority of
You have accessJournal of UrologyTechnology & Instruments: Robotics/Laparoscopy/Ureteroscopy III1 Apr 20101083 RETROPERITONEAL LAPAROENDOSCOPIC SINGLE SITE (LESS) RADICAL NEPHRECTOMY: COMPARISON WITH CONVENTIONAL LAPAROSCOPIC SURGERY Tae Hee Oh, Dong Soo Ryu, and Hee Chang Jung Tae Hee OhTae Hee Oh Masan, Republic of Korea More articles by this author , Dong Soo RyuDong Soo Ryu Masan, Republic of Korea More articles by this author , and Hee Chang JungHee Chang Jung Daegu, Republic of Korea More
Purpose: To review the clinical manifestations, indications and the management outcomes of adult patients with ureteroceles. Materials and Methods: Between 1995 and 2006, 20 adult patients (9 females, 3 males) with ureteroceles were investigated for their clinical symptoms, type of ureterocele and renal function. The outcomes of surgical or conservative management, according to the patients' symptoms were also individually analyzed. The median follow-up was 38 months (12-50 months). Results: The
Research Areas
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