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Tae Soo Ham

Sungkyunkwan University

About the Lab

Professor Tae Soo Ham's research lab specializes in clinical and translational pain management, with a focus on neuromodulation, regional anesthesia, and the neurobiological mechanisms underlying acute and chronic pain. The lab investigates non-pharmacological and pharmacological interventions—such as electrical stimulation of acupoints, femoral nerve blocks, and gabapentin therapy—to optimize postoperative pain control and improve functional recovery. Key research directions include identifying biomarkers of pain sensitivity, evaluating anesthetic depth monitoring (e.g., BIS and AAI), and exploring preventive strategies for postoperative complications like arrhythmias and neuropathic pain. The lab integrates animal models with human clinical studies to bridge basic science insights with clinical applications.

postoperative painneuromodulationanesthesia monitoringneuropathic painregional anesthesia

Research Overview

Papers
32
Total Citations
99
Papers (5y)
10
Primary Field

Research Output Trend

Figures are computed from collected data and may differ slightly.

Publications per year (5y)
10total
2009
2010
2011
2013
2015
Citations per year (5y)
27total
20092010201120132015

Selected Papers

15
1
Article|22 citations·2007
The Effect of 2 Hz and 100 Hz Electrical Stimulation of Acupoint on Ankle Sprain in Rats
함태수
http://kmbase.medric.or.kr/Main.aspx?d=KMBASE&m=VIEW&i=0191120070220020347

The electrical stimulation of acupoint (ESA) releases several endogenous neuropeptides, which play important roles in management of pain and inflammation. ESA with low and high frequencies has been shown to release different neuropepides, suggesting its various therapeutic effects. Pain and edema are major problems for ankle sprain. However, there have been few reports on the effects of ESA for ankle sprain. We aimed to investigate that ESA can reduce pain and edema resulting from ankle sprain,

2
Article|21 citations·2006
A Correlation between Low Back Pain and Associated Factors: A Study Involving 772 Patients who Had Undergone General Physical Examination
Min A Kwon, 심우석, 김명희, 곽미숙, 함태수, 김갑수, 김정수, 최윤호, Jeong Heon Park, 조현성, Tae Hyeong Kim
http://kmbase.medric.or.kr/Main.aspx?d=KMBASE&m=VIEW&i=0191120060210061086

Many factors are associated with the development of low back pain. Among them, exercise, obesity, smoking, age, educational level and stress are the most common. This study examined the association of these factors with low back pain. An additional aim was to determine a procedure for preventing low back pain. This study analyzed the responses to a questionnaire sent to 772 individuals who had undergone a medical examination at this hospital in 2003 and excluded the individuals who had shown sym

3
Article|11 citations·2007
Risk Factors for an Intraoperative Arrhythmia during Esophagectomy
함태수, 이정진, 양미경, 김지애
http://kmbase.medric.or.kr/Main.aspx?d=KMBASE&m=VIEW&i=0311120070480030474

Purpose: Arrhythmias after an esophagectomy (most commonly atrial fibrillation) are a significant contributing factor to patient morbidity. However, the significance of an intraoperative arrhythmia is not completely understood. The aim of this retrospective study was to determine the occurrence and risk factors for developing intraoperative arrhythmias in patients undergoing an esophagectomy. Materials and Methods: We reviewed the records of 427 patients who underwent a transthoracic esophagecto

4
Article|11 citations·2011
Effect of Combined Single-Injection Femoral Nerve Block and Patient-Controlled Epidural Analgesia in Patients Undergoing Total Knee Replacement
Ae-Ryung Lee, Sangwook Ko, 최덕환, 최수주, 함태수, 김가현, 문영완
http://kmbase.medric.or.kr/Main.aspx?d=KMBASE&m=VIEW&i=0311120110520010145

Purpose: Total knee replacement is one of the most painful orthopedic procedures, and effective pain relief is essential for early mobility and discharge from hospital. The aim of this study was to evaluate whether addition of single-injection femoral nerve block to epidural analgesia would provide better postoperative pain control, compared to epidural analgesia alone, after total knee replacement. Materials and Methods: Thirty-eight patients received a single-injection femoral nerve block with

5
Article|10 citations·2009
Protective Effects of Gabapentin on Allodynia and α2δ1-Subunit of Voltage-dependent Calcium Channel in Spinal Nerve-Ligated Rats
함태수, 안현주, 배창대, 임승운, 조현성, 이상민, 심우석, 김지애, 곽미숙, 최수주, 김한섭
Journal of Korean Medical Science

This study was designed to determine whether early gabapentin treatment has a protective analgesic effect on neuropathic pain and compared its effect to the late treatment in a rat neuropathic model, and as the potential mechanism of protective action, the α2δ1-subunit of the voltage-dependent calcium channel (α2δ1-subunit) was evaluated in both sides of the L5 dorsal root ganglia (DRG). Neuropathic pain was induced in male Sprague-Dawley rats by a surgical ligation of left L5 nerve. For the ear

6
Article|6 citations·2004
슬관절 전치환 성형술을 받는 정형외과 환자의 척추마취에서Propofol 목표 농도 조절 주입을 이용한 단계적 진정 시BIS, AEP와 진정점수의 상관관계
이상민, 강진구, 임승운, 정익수, 함태수, 김진경, 신병섭, 안현주, 윤소정

Background: We performed a prospective, randomized study to investigate the relations between BIS (bispectral index, BISTM monitor), AAI (mid-latency AEP, A-line ARX index) and depth of sedation, and assessed two different memory functions at OAA/S score 2 under spinal anesthesia. Methods: 44 ASA physical status 1-2 patients, scheduled for elective total knee replacement arthroplasty were randomly allocated to either the BIS group (22) or the AEP group (22). Under spinal anesthesia, patients we

7
Article|6 citations·2006
두부 하강, 외회전 자세에서의 내경정맥과 경동맥의 관찰
정익수, 권민아, 황희윤, 박정헌, 여진석, 김정수, 함태수, 이상민, 조현성

Background: This study evaluated the position and relationship between the right internal jugular vein (IJV) and the surrounding external landmarks using ultrasonography. Methods: Fifty-four patients undergoing central vein access for cardiac surgery were enrolled in this study. The IJV, carotid artery (CA) and sternocleidomastoid muscle (SCM) at the cricoid cartilage level in 15o trendelenburg position with 30o head rotation were examined using a two dimensional ultrasound transducer of a TEE

8
Article|2 citations·2007
백서의 족관절 염좌모델에서 동시에 적용한 전기침구가 염좌 통증에 미치는 효과
함태수, 조현성, 곽미숙, 이숙영

Simultaneous acupuncture to two or more acupoints has been used to improve acupuncture-induced effects in clinical practice. However, there is little evidence supporting the effects of simultaneous electroacupuncture (EA). This study examined whether simultaneous EA with 2 and 2 Hz or 2 and 100 Hz can produce synergic effects on ankle-sprained pain in rats. Methods: Ankle sprain pain was induced by manually overextending the lateral ligament of the right ankle in rats. Electrical stimulation wi

9
Article|2 citations·2006
추간판 탈출증 환자에서 길잡이철사가 삽입된 경막외카테터를 이용한 미추경막외조영술
심우석, 김지애, 함태수, 김갑수, 조현성, 김태형, 고상욱, 이석진, 황희윤, 최수주, 김정수

=Caudal Epidural Injection with a Guidewire-Reinforced Epidural Catheter inPatients with Herniated Nucleosus PulposeJustin Sangwook Ko, M.D., Seok Jin Lee, M.D., Hee Youn Hwang, M.D., Woo Seok Sim, M.D.,Soo Joo Choi, M.D., Jie Ae Kim, M.D., Chung Su Kim, M.D., Tae Soo Hahm, M.D.,Gaab Soo Kim, M.D., Hyun Sung Cho, M.D., and Tae Hyeong Kim, M.D.

10
Article|2 citations·2010
Unilateral massive hydrothorax in a gynecologic patient with pseudo-Meigs’ syndrome -A case report-
함태수, 함지선, 강지영

Pseudo-Meigs’ syndrome is characterized by the presence of a benign ovarian tumor associated with ascites and a right-sided hydrothorax. The major problem associated with pseudo-Meigs’ syndrome is the respiratory distress caused by a giant mass in the peritoneal space, massive ascites and pleural effusion. Even if there are no respiratory problems prior to surgery, potential respiratory dysfunction can occur during the peri-anesthetic period, leading to hypoxia, hypercapnea and respiratory acido

11
Article|1 citations·2010
고비중 0.5% Bupivacaine의 척추마취 후에 발생된 지속적인 신경손상 -증례 보고-
함태수, 고저스틴상욱, 진현승

Persistent neurologic injury is a rare but feared complication of neuroaxial anesthesia.Local anesthetics are believed to be an important cause.A 68-year-old man with an ASA physical status of 2 was scheduled to undergo elective knee arthroplasty.He had no clinical evidence of neurological deficits before the operation. Spinal anesthesia was administered using 10 mg of 0.5% bupivacaine and 20μg of fentanyl without difficulty or complications during the procedure.On the second postoperative day,

12
Article|1 citations·2006
백서의 족관절 염좌모델에서 전기침구에 효과적인 침구점
조현성, 양미경, 유래근, 함태수

Background: The stimulation and selection of an effective acupoint is important for producing effective analgesia in electraoacupuncture. This study examined the effect of electroacupuncture to different acupoints and investigated the effective acupoint for ankle-sprained pain in rats. Methods: A Sprain was produced by manually overextending the lateral ligament of the right ankle in rats. Electrical stimulation was delivered individually to five acupoints: bilateral Yangno (SI6s), contralater

13
Article|1 citations·2005
수술 전 불안지수와 혈중 Potassium 농도와의 상관관계
조현성, 함태수, 서성원

Background: Patients experience preoperative anxiety which stimulates the release of catecholamines. They have influences on serum K+ level by shifting them into the intracellular space. The purpose of this study is to determine whether there is a correlation between anxiety and the serum potassium level immediately before induction of anesthesia. Methods: Thirty patients were asked about their anxiety levels at 7:00 pm of the day before surgery and immediately before induction of anesthesia: 0

14
Article|1 citations·2011
Involuntary movements after ramosetron injection during propofol anesthesia −A case report−
김영순, 함태수, 정양훈, 이정진

We report here on a case of a female patient with involuntary movements that lasted for approximately 8 hours after being administered a single dose of ramosetron, a highly selective serotonin 5-hydroxytryptamine type 3 (5-HT3) receptor antagonist,to prevent postoperative nausea and vomiting (PONV) at the end of general anesthesia with using propofol. To the best of our knowledge, this is the first report of involuntary movement related to ramosetron. (Anesth Pain Med 2011; 6: 143∼145)

15
Article|1 citations·2009
전기침구법
함태수

Electrical stimulation of acupoint (EA), a form of electrotherapy, involves passing an electrical current via pairs of acupuncture needles attached to a device that generates an electrical pulse. This electrical generator is used to control and adjust the stimulus parameters. EA is quite similar to traditional acupuncture in that the same points are stimulated. However, EA stimulates a larger area than a specific point. In addition, greater control of stimulus parameters is possible with EA, whi

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