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Wan Jae Yi

Sungkyunkwan University · Medicine

About the Lab

Professor Wan Jae Yi's research lab specializes in diagnostic radiology and biomedical imaging, with a focus on developing advanced imaging agents and techniques for early detection and precise diagnosis of gastrointestinal and urological diseases. The lab investigates pH-responsive nanomaterials for targeted MRI contrast imaging, particularly for acidic pathological environments such as tumors, and explores the radiological features of various neoplastic and inflammatory conditions, including cholangiocarcinoma, gallbladder polyps, and eosinophil-related hepatic lesions. The team also evaluates clinical interventional procedures, such as emergency percutaneous nephrostomy, to improve patient outcomes in urological emergencies. Their work bridges molecular imaging, radiological diagnostics, and clinical interventional radiology to enhance disease detection and management.

MRI contrast agentspH-responsive micellescholangiocarcinomainterventional radiologyabdominal imaging

Research Overview

Papers
427
Total Citations
13,087
Papers (5y)
29
Primary Field
Medicine

Research Output Trend

Figures are computed from collected data and may differ slightly.

Publications per year (5y)
29total
2022
2023
2024
2025
2026
Citations per year (5y)
150total
20222023202420252026

Selected Papers

15
1
Review|143 citations·2001
Radiologic Spectrum of Cholangiocarcinoma: Emphasis on Unusual Manifestations and Differential Diagnoses
Won Jae Lee, Hyo Keun Lim, Kyung Mi Jang, Seung H. Kim, Soon Jin Lee, Jae Hoon Lim, In Wook Choo
SJR Q1Radiographics

Most cholangiocarcinomas are ductal adenocarcinomas that arise from both intra- and extrahepatic bile duct epithelium, and their typical growth pattern can be classified as exophytic, infiltrative, polypoid, or a combination of these. Those of unusual histologic type (eg, mucin-hypersecreting cholangiocarcinoma, squamous adenocarcinoma, biliary cystadenocarcinoma, and mucinous carcinoma) show a growth pattern different from that of the typical ones (ie, ductal). Cholangiocarcinomas frequently de

SurgeryMedicine
2
Article|127 citations·1994
Emergency Percutaneous Nephrostomy: Results and Complications
Won Jae Lee, Uresh Patel, Smita S. Patel, George Pillari
SJR Q2Journal of Vascular and Interventional RadiologyOA

PURPOSE: Percutaneous nephrostomy is a well-established standardized procedure in the management of patients with various urologic problems. The goal of this study was to evaluate the effectiveness and safety of percutaneous nephrostomy in an emergency setting. PATIENTS AND METHODS: Emergency percutaneous nephrostomy was performed in 160 patients with ages ranging from 2 to 89 years (mean, 52 years). Access to the kidney was planned and achieved with C-arm fluoroscopic guidance. RESULTS: The ini

Pulmonary and Respiratory MedicineMedicine
3
Article|116 citations·2012
Fe3O4/MnO hybrid nanocrystals as a dual contrast agent for both T1- and T2-weighted liver MRI
Geun Ho Im, Soo Min Kim, Dong-Gyu Lee, Won Jae Lee, Jung Hee Lee, In Su Lee
SJR Q1Biomaterials
Materials ChemistryMaterials Science
4
Article|112 citations·2012
The use of pH-sensitive positively charged polymeric micelles for protein delivery
Guanghui Gao, Min Jung Park, Yi Li, Geun Ho Im, Jaehoon Kim, Hun Nyun Kim, Won Jae Lee, Won Jae Lee, Pyoung Jeon, Oh Young Bang, Jung Hee Lee, Jung Hee Lee
SJR Q1Biomaterials
BiomaterialsMaterials Science
5
Article|107 citations·2010
Magnetite‐Nanoparticle‐Encapsulated pH‐Responsive Polymeric Micelle as an MRI Probe for Detecting Acidic Pathologic Areas
Guanghui Gao, Geun Ho Im, Min-Sang Kim, Won Jae Lee, Won Jae Lee, Jehoon Yang, Hyesung Jeon, Jung Hee Lee, Jung Hee Lee, Doo Sung Lee
SJR Q1Small

A facile and powerful pH-responsive polymeric micelle encapsulates Fe3O4 nanoparticles as an acid-targeting MRI contrast agent for pathologic diagnosis. This MRI probe remains in a micellar state in the physiological environment whereas it can be dissolved in acidic pathological areas. More biomedical applications will be possible owing to its unique ability to target an acidic pathologic environment.

Materials ChemistryMaterials Science
6
Article|97 citations·2010
The value of PET/CT for preoperative staging of advanced gastric cancer: Comparison with contrast-enhanced CT
Eun Young Kim, Won Jae Lee, Dongil Choi, Soon Jin Lee, Joon Young Choi, Byung‐Tae Kim, Hyung Sik Kim
SJR Q1European Journal of Radiology
Pulmonary and Respiratory MedicineMedicine
7
Article|76 citations·2008
Detecting recurrence of gastric cancer: the value of FDG PET/CT
Min Jung Park, Won Jae Lee, Hyo Keun Lim, Ko Woon Park, Joon Young Choi, Byung‐Tae Kim
Abdominal Imaging
Pulmonary and Respiratory MedicineMedicine
8
Article|63 citations·2013
Mn2+-doped silica nanoparticles for hepatocyte-targeted detection of liver cancer in T1-weighted MRI
Soo Min Kim, Geun Ho Im, Dong-Gyu Lee, Jung Hee Lee, Won Jae Lee, In Su Lee
SJR Q1Biomaterials
BiomaterialsMaterials Science
9
Article|58 citations·2007
Utilization of the emergency room: impact of geographic distance
Jae Eun Lee, Jung Hye Sung, William B. Ward, Peter J. Fos, Won Jae Lee, Jae Chang Kim
SJR Q2Geospatial healthOA

The aim of this study was to estimate the distance Mississippi patients must travel to access hospital-based emergency rooms (ERs) and to determine whether an association exists between geographic distance and ER utilization. To that end, great circle distances between Census Block Group Centroid Points and 89 hospitals with emergency departments were calculated for the State of Mississippi. Data on the socio-demographic characteristics of each block group came from the 2000 US Census data. Logi

Emergency MedicineMedicine
10
Article|53 citations·1986
Percutaneous nephrolithotomy: Analysis of 500 consecutive cases
Won Jae Lee, Arthur D. Smith, Vincent Cubelli, Frances Vernace
Urologic Radiology
Pulmonary and Respiratory MedicineMedicine
11
Article|48 citations·2010
Differentiation of Nonneoplastic and Neoplastic Gallbladder Polyps 1 cm or Bigger With Multi-Detector Row Computed Tomography
Ko Woon Park, Seong Hyun Kim, Seong‐Ho Choi, Won Jae Lee
SJR Q3Journal of Computer Assisted Tomography

Size bigger than 1.5 cm, sessile shape, and perception on unenhanced images are the main factors that differentiate neoplastic from nonneoplastic gallbladder polyps 1 cm or bigger.

SurgeryMedicine
12
Article|47 citations·1999
Foci of eosinophil-related necrosis in the liver: imaging findings and correlation with eosinophilia.
Won Jae Lee, Hyo Keun Lim, Jae Hoon Lim, S H Kim, Seon-Hee Choi, S J Lee
SJR Q1American Journal of Roentgenology

Foci of eosinophil-related necrosis cause focal hepatic lesions of varying size, shape, and number on helical CT and sonography. The number and extent of these foci were closely correlated to eosinophil counts in the peripheral blood.

RheumatologyMedicine
13
Article|43 citations·1994
Emergency Percutaneous Nephrostomy: Technical Success Based on Level of Operator Experience
Won Jae Lee, David J. Mond, Mahendra P. Patel, George Pillari
SJR Q2Journal of Vascular and Interventional Radiology
Pulmonary and Respiratory MedicineMedicine
14
Article|37 citations·1976
Mediastinal Lipomatosis in Simple Obesity
Won Jae Lee, G. A. Fattal
SJR Q1CHEST Journal
SurgeryMedicine
15
Article|35 citations·2002
Assessment of Therapeutic Response in Hepatocellular Carcinoma Treated With Percutaneous Radio Frequency Ablation
Dongil Choi, Hyo Keun Lim, Seung Hoon Kim, Won Jae Lee, Hyun‐Jung Jang, Hana Kim, Soon Jin Lee, Jae Hoon Lim
SJR Q2Journal of Ultrasound in Medicine

OBJECTIVE: To compare the results of multiphase helical computed tomography and power Doppler ultrasonography with a microbubble contrast agent in the assessment of the therapeutic response to radio frequency ablation in hepatocellular carcinoma. METHODS: In 66 patients with 73 nodular hepatocellular carcinomas ranging from 1.0 to 4.0 cm (mean, 2.6 cm) in diameter, contrast-enhanced power Doppler ultrasonography was performed after intravenous bolus injection of a galactose-based microbubble con

HepatologyMedicine

Research Areas

HepatologySurgeryRadiology, Nuclear Medicine and ImagingEpidemiologyOncologyPulmonary and Respiratory Medicine

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