Yeon-Ju Ryu

The data regarding risk factors for death during tuberculosis (TB) treatment areinconsistent, and few studies examined this issue in Korea. The purpose of this study wasto evaluate baseline prognostic factors for death during treatment of adult patients withpulmonary TB in Korea. A multicenter retrospective cohort study of 2,481 patients whoreceived TB treatment at eight hospitals from January 2009 to December 2010 wasperformed. Successful treatment included cure (1,129, 45.5%) and treatment com

Nontuberculous mycobacteria (NTM) are emerging pathogens that affect both immunocompromised and immunocompetent patients. The incidence and prevalence of NTM lung disease are increasing worldwide and rapidly becoming a major public health problem. For the diagnosis of NTM lung disease, patients suspected to have NTM lung disease are required to meet all clinical and microbiologic criteria. The development of molecular methods allows the characterization of new species and NTM identification at a

Background/Aims: Gastroesophageal reflux disease is one of the most commoncauses of chronic cough and is a potential risk factor for the exacerbation of chronicobstructive pulmonary disease (COPD). The aim of this study was to investigatethe prevalence and risk factors for reflux esophagitis (RE) in COPD patients. Methods: From our hospital database, between September 2006 and April 2010,we searched for subjects who were 40 years old or older and had undergone bothpostbronchodilator spirometry a

Background/Aims: Patients with chronic airway lung diseases often experience depression and anxiety, but little information is available regarding Koreans with these conditions. We thus assessed depression and anxiety in Korean patients with chronic airway lung diseases. Methods: The degree of depression and anxiety in 84 outpatients with chronic obstructive pulmonary disease (COPD), 37 with asthma, 33 with bronchiectasis, and 73 healthy controls were evaluated by the Beck Depression Inventory (

Background/Aims: Obesity is a worldwide concern, but its influence on critical care outcomes is not well understood. We tested the hypothesis that abnormal body mass index (BMI) would be an independent predictor of higher mortality rates in intensive care unit (ICU). Methods: We retrospectively reviewed patients who had admitted to the ICU from January 2007 to December 2007. Admission BMI was analyzed as both a three categorical (underweight, < 18.5 kg/m2; normal weight, 18.5to 24.9 kg/m2; overw

배 경:고호모시스테인 혈증 (Hyperhomocysteinemia, HHcy)은 심혈관계 질환 발생의 독립적인 위험인자로 간주되고 있다. 혈액투석 환자에서 호모시스테인 (Hcy)의 농도는 증가되는 것으로 보고되고 있으나 임상적 의의는 아직 불분명한 상태이다. 방 법:연구자들은 현재 유지 혈액투석 중인 환자 44명 (남:여 24:20, 평균 연령 53세, 평균 투석기간 38개월)을 대상으로 혈중 Hcy의 농도를 측정하고, 환자의 심혈관계 질환 (심근경색, 뇌경색 및 말초 혈액질환)의 발생빈도, 동정맥루 폐쇄 등의 기왕력 조사와 함께 Hcy 대사의 보조 인자인 혈중 엽산 및 비타민 B12 등의 농도를 측정하여 건강 대조군 (50명, 남:여 25:25, 평균 연령 43세)과 비교하고, 각각의 변수간의 상관관계를 조사하였다. 대상 환자들은 최소한 4개월 이상 매일 엽산 1 mg, 비타민 B6 10 mg, 비타민 B12 6 µg을 포함하는 경구 비타민 제제를 복용 중이었다. 결 과:혈액투석

Pulmonary tuberculosis (TB) persists as a great public health problem in Korea. Increases in the overall age of the population and the rise of drug-resistant TB have reinforced the need for rapid diagnostic improvements and new modalities to detect TB and drug-resistant TB, as well as to improve TB control. Standard guidelines and recent advances for diagnosing pulmonary TB are summarized in this article. An early and accurate diagnosis of pulmonary TB should be established using chest X-ray, sp

Background/Aims: In Korea, medications are available by prescription from a physician, or can be purchased over-the-counter (OTC) without a prescription. Education regarding both prescribed and OTC drugs is important to minimize side effects and avoid drug abuse. The risk of side effects due to polypharmacy is increasing due to the growing number of elderly patients with comorbidities. Methods: There are various clinical guidelines for physicians, but it is difficult for patients and their careg

배경:최근 노인 환자의 수술 빈도가 증가함에 따라, 수술 후 폐 합병증이 수술 후 이환과 사망의 중요한 원인이 되고 있다. 방법:전신 마취 하에 흉부외 수술을 받은 65세 이상의 환자 206명을 대상으로 수술 후 폐 합병증의 발생률과 예측인자를 후향적으로 조사하였다. 수술 후 폐 합병증은 수술 후에 새로 발생한 무기폐, 폐렴, 폐색전증, 급성호흡부전으로 정의하였다. 결과:수술 후 폐 합병증의 발생률이 13.6%(28/266)이었다. 수술 후 폐 합병증의 유의한 예측인자는 기저 폐 질환(odds ratio, 3.2; p<0.01), 수술 전 2주 이내 상기도 감염(OR, 10.6; p<0.05), 상복부 절개 수술(OR, 4.9; p<0.001), 수술 시간이 3시간 이상(OR, 2.9; p<0.05), PaO2가 75 mmHg 미만(OR, 3.4; p<0.01), 폐포-동맥혈간 산소 분압차[D(A-a)O2]가 30 mmHg 이상(OR, 5.9; p<0.001), 혈청 알부민이 3

Background: The incidence of tuberculosis (TB) in Korea is relatively high compared to the other Organisation for Economic Co-operation and Development (OECD) countries, with a prevalence of 71 per 100,000 in 2012, although the incidence is declining. Real-time polymerase chain reaction (PCR) has been introduced for the rapid diagnosis of TB. Recently, its advantage lies in higher sensitivity and specificity for the diagnosis of TB. This study evaluated the clinical accuracy of real-time PCR usi

Background : Community-acquired pneumonia (CAP) remains a common and serious condition worldwide. The mortality from severe CAP remains high, and this has reached 50% in some series. This study was conducted to determine the mortality and predictors that contribute to in-hospital mortality for patients who exhibit CAP and acute respiratory failure that requires mechanical ventilation. Methods : We retrospectively reviewed the medical records of 85 patients with severe CAP as a primary cause of

Background: Obstructive airway disease patients with increased variability of airflow and incompletely reversible airflow obstruction are often categorized as having asthma–chronic obstructive pulmonary disease (COPD) overlap syndrome (ACOS). ACOS is heterogeneous with two sub-phenotypes: asthma-ACOS and COPD-ACOS. The objective of this study was to determine the difference in risk of exacerbation between the two sub-phenotypes of ACOS. Methods: A total of 223 patients exhibiting incompletely re

The sandwich sign is used to describe mesenteric lymphoma in which mesenteric vessels and fat are enveloped by enlarged mesenteric lymph nodes. We present two cases of primary pleural lymphoma demonstrating the “pleural sandwich sign”. Contrast-enhanced computed tomography showed conglomerated parietal pleural and extrapleural masses encasing the intercostal arteries. Histopathological examinations confirmed low grade marginal zone B-cell lymphoma in an 80-yearold man and diffuse large B-cell ly

연구배경: 표피성장인자수용체(epidermal growth factor receptor, EGFR) 티로신 활성효소 억제제(tyrosine kinase inhibitor, TKI)는 진행성 비소세포폐암의 새로운 치료제이다. 몇몇 연구 결과 gefitinib와 erlotinib에 대한 반응률과 반응 예측인자에 차이가 있을 가능성을 제시하 였다. 저자들은 한국인 진행성 비소세포폐암에서 gefitinib와 erlotinib의 효과 및 독성을 비교하고 각 약제에 대 해 서로 다른 반응 예측인자가 있는지 평가하였다. 방 법: 2003년 7월부터 2009년 2월까지 이화여자대학 교부속병원에서 진행성 비소세포폐암으로 gefitinib 또는 erlotinib로 치료 받은 환자들의 임상정보를 수집하였다. 중앙 생존기간은 Kaplan-Meier법으로 계산하였다. 결 과: 대상 환자는 총 86명이었다(gefitinib군 52명 대 erlotinib군 34명). 나이의 중앙값은 64세였고 53명(62%)