Yong-hee Kim
Hanyang University · Biochemistry, Genetics and Molecular Biology
About the Lab
Professor Yong-hee Kim's research lab specializes in the development of advanced drug and gene delivery systems, with a focus on innovative biomaterials and nanotechnologies for targeted therapeutic applications. The lab pioneers the design of biodegradable and stimuli-responsive delivery platforms—such as reducible poly(oligo-D-arginine), self-locking microneedles, and peptide-based nanoparticles—aimed at enhancing transfection efficiency, reducing toxicity, and enabling precise microdosing. Key research directions include targeted delivery to metabolic tissues (e.g., adipose tissue), overcoming drug resistance in cancer therapy, and improving the stability and patient compliance of gene-based treatments. The lab integrates cutting-edge fabrication techniques like 3D micro-stereolithography with molecular design to create smart, biocompatible systems for chronic and metabolic diseases.
Research Overview
Research Output Trend
Figures are computed from collected data and may differ slightly.
Selected Papers
15Nonarginine (D-R9) has been reported to be one of the most efficacious protein transduction domains (PTDs) for the intracellular cargo delivery such as DNA, RNA, proteins, and particles. Although oligoarginines are capable of forming polyplex with DNA by electrostatic interaction, the length of oligoarginine can affect the toxicity and gene expression. The reducible poly(oligo-D-arginine) (rPOA) composed of the Cys-(D-R9)-Cys repeating unit forming disulfide bonds between terminal cysteinyl-thio
Advancements in micro-resolution 3D printers have significantly facilitated the development of highly complex mass-producible drug delivery platforms. Conventionally, due to the limitations of micro-milling machineries, dissolvable microneedles (MNs) are mainly fabricated in cone-shaped geometry with limited drug delivery accuracy. Herein, to overcome the limitations of conventional MNs, a novel projection micro-stereolithography 3D printer-based self-locking MN for precise skin insertion, adhes
A wide variety of drug delivery systems have been developed for the delivery of anticancer agents. One of the most frequently used natural biomaterials in drug delivery systems is polysaccharides; however, they are difficult to digest and to eliminate from the body after systemic administration due to their high molecular weight natures and the absence of degrading enzymes. Therefore, the development of degradable and eliminable natural biomaterials is critical for successful in vivo application
Research Areas
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