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Yong-Sang Yoo

Korea University · Engineering

About the Lab

Professor Yong-Sang Yoo's research lab specializes in advanced optical and nanoscale analytical techniques, focusing on the development of innovative biosensors, surface-sensitive detection platforms, and next-generation optical devices. The lab explores dynamic molecular interactions at nanoscale interfaces, particularly in lipid membranes and biomolecular systems, using cutting-edge methods such as dielectrophoresis, electrokinetic manipulation, and in situ spectroscopy. A key research direction involves overcoming technical challenges in detecting ultradilute and submicron pollutants like nanoplastics, while also advancing bioelectronic sensing through novel membrane architectures that mitigate ionic screening effects. The lab integrates experimental physics, materials science, and biophysics to address critical problems in environmental monitoring and biomedical diagnostics.

biosensorsnanoplastic detectiondielectrophoresisoptical camouflagebioelectronic sensing

Research Overview

Papers
94
Total Citations
1,109
Papers (5y)
35
Primary Field
Engineering

Research Output Trend

Figures are computed from collected data and may differ slightly.

Publications per year (5y)
35total
2022
2023
2024
2025
2026
Citations per year (5y)
443total
20222023202420252026

Selected Papers

15
1
Article|59 citations·2020
Asymmetric optical camouflage: tuneable reflective colour accompanied by the optical Janus effect
Taehyun Kim, Eui‐Sang Yu, Young-Gyu Bae, Jongsu Lee, In Soo Kim, Seok Chung, Seung‐Yeol Lee, Yong‐Sang Ryu
SJR Q1Light Science & ApplicationsOA

Going beyond an improved colour gamut, an asymmetric colour contrast, which depends on the viewing direction, and its ability to readily deliver information could create opportunities for a wide range of applications, such as next-generation optical switches, colour displays, and security features in anti-counterfeiting devices. Here, we propose a simple Fabry-Perot etalon architecture capable of generating viewing-direction-sensitive colour contrasts and encrypting pre-inscribed information upo

Media TechnologyEngineering
2
Article|53 citations·2020
Precise capture and dynamic relocation of nanoparticulate biomolecules through dielectrophoretic enhancement by vertical nanogap architectures
Eui‐Sang Yu, Hyojin Lee, Sun‐Mi Lee, Jiwon Kim, Taehyun Kim, Jongsu Lee, Chulki Kim, Minah Seo, Jae Hun Kim, Young Tae Byun, Seung-Chul Park, Seung‐Yeol Lee
SJR Q1Nature CommunicationsOA

Toward the development of surface-sensitive analytical techniques for biosensors and diagnostic biochip assays, a local integration of low-concentration target materials into the sensing region of interest is essential to improve the sensitivity and reliability of the devices. As a result, the dynamic process of sorting and accurate positioning the nanoparticulate biomolecules within pre-defined micro/nanostructures is critical, however, it remains a huge hurdle for the realization of practical

Biomedical EngineeringEngineering
3
Article|49 citations·2014
Reconstituting ring-rafts in bud-mimicking topography of model membranes
Yong‐Sang Ryu, In‐Ho Lee, Jeng-Hun Suh, Seung Chul Park, Soojung Oh, Luke R. Jordan, Nathan J. Wittenberg, Sang‐Hyun Oh, Noo Li Jeon, Byoungho Lee, Atul N. Parikh, Sin‐Doo Lee
SJR Q1Nature CommunicationsOA

During vesicular trafficking and release of enveloped viruses, the budding and fission processes dynamically remodel the donor cell membrane in a protein- or a lipid-mediated manner. In all cases, in addition to the generation or relief of the curvature stress, the buds recruit specific lipids and proteins from the donor membrane through restricted diffusion for the development of a ring-type raft domain of closed topology. Here, by reconstituting the bud topography in a model membrane, we demon

Molecular BiologyBiochemistry, Genetics and Molecular Biology
4
Article|44 citations·2024
Challenges and Recent Analytical Advances in Micro/Nanoplastic Detection
Seungyeop Choi, Seung‐Ha Lee, Myung‐Ki Kim, Eui‐Sang Yu, Yong‐Sang Ryu
SJR Q1Analytical Chemistry

Despite growing ecological concerns, studies on microplastics and nanoplastics are still in their initial stages owing to technical hurdles in analytical techniques, especially for nanoplastics. We provide an overview of the general attributes of micro/nanoplastics in natural environments and analytical techniques commonly used for their analysis. After demonstrating the analytical challenges associated with the identification of nanoplastics due to their distinctive characteristics, we discuss

PollutionEnvironmental Science
5
Article|39 citations·2022
Real-Time Underwater Nanoplastic Detection beyond the Diffusion Limit and Low Raman Scattering Cross-Section via Electro-Photonic Tweezers
Eui‐Sang Yu, Eui Tae Jeong, Seung‐Ha Lee, In Soo Kim, Seok Chung, Seungyeon Han, Inhee Choi, Yong‐Sang Ryu
SJR Q1ACS Nano

Emerging as substantial concerns in the ecosystem, submicron plastics have attracted much attention for their considerable hazards. However, their effect and even amount in the environment remain unclear. Establishing a substantive analytic platform is essential to expand the understanding of nanoplastics. However, the issues of diffusion and detection limit that arise from ultradiluted concentration and extremely small scales of nanoplastics leave significant technical hurdles to analyze the na

Biomedical EngineeringEngineering
6
Article|36 citations·2021
Ionic contrast across a lipid membrane for Debye length extension: towards an ultimate bioelectronic transducer
Donggeun Lee, Woo Hyuk Jung, Suho Lee, Eui‐Sang Yu, Taikjin Lee, Jae Hun Kim, Hyun Seok Song, Kwan H. Lee, Seok Lee, Sang‐Kook Han, Myung Chul Choi, Dong June Ahn
SJR Q1Nature CommunicationsOA

Despite technological advances in biomolecule detections, evaluation of molecular interactions via potentiometric devices under ion-enriched solutions has remained a long-standing problem. To avoid severe performance degradation of bioelectronics by ionic screening effects, we cover probe surfaces of field effect transistors with a single film of the supported lipid bilayer, and realize respectable potentiometric signals from receptor-ligand bindings irrespective of ionic strength of bulky solut

Molecular BiologyBiochemistry, Genetics and Molecular Biology
7
Article|35 citations·2021
Nanoscale Terahertz Monitoring on Multiphase Dynamic Assembly of Nanoparticles under Aqueous Environment
Eui‐Sang Yu, Sang‐Hun Lee, Geon Lee, Q‐Han Park, Aram J. Chung, Minah Seo, Yong‐Sang Ryu
SJR Q1Advanced ScienceOA

Probing the kinetic evolution of nanoparticle (NP) growth in liquids is essential for understanding complex nano-phases and their corresponding functions. Terahertz (THz) sensing, an emerging technology for next-generation laser photonics, has been developed with unique photonic features, including label-free, non-destructive, and molecular-specific spectral characteristics. Recently, metasurface-based sensing platforms have helped trace biomolecules by overcoming low THz absorption cross-sectio

Biomedical EngineeringEngineering
8
Article|30 citations·2017
Ultrasensitive terahertz sensing of gold nanoparticles inside nano slot antennas
Yong‐Sang Ryu, Dongkyu Lee, Ji-Hun Kang, Sang‐Hun Lee, Eui‐Sang Yu, Minah Seo
SJR Q1Optics ExpressOA

We introduce a robust control method of terahertz (THz) transmission by tuning filling factors of Au nanoparticles (AuNPs) inside nano slot antennas. AuNPs in sub-100 nm diameters were spread over the nano slot antennas, followed by sweeping them into the slots. AuNPs can be efficiently localized and inserted into nano slots where the THz fields are greatly enhanced, by a "squeegee" made of the polydimethylsiloxane (PDMS). The sweeping of the AuNPs results in further dramatic reduction of THz tr

Electrical and Electronic EngineeringEngineering
9
Article|23 citations·2015
Lipid Membrane Deformation Accompanied by Disk-to-Ring Shape Transition of Cholesterol-Rich Domains
Yong‐Sang Ryu, Daehan Yoo, Nathan J. Wittenberg, Luke R. Jordan, Sin‐Doo Lee, Atul N. Parikh, Sang‐Hyun Oh
SJR Q1Journal of the American Chemical Society

During vesicle budding or endocytosis, biomembranes undergo a series of lipid- and protein-mediated deformations involving cholesterol-enriched lipid rafts. If lipid rafts of high bending rigidities become confined to the incipient curved membrane topology such as a bud-neck interface, they can be expected to reform as ring-shaped rafts. Here, we report on the observation of a disk-to-ring shape morpho-chemical transition of a model membrane in the absence of geometric constraints. The raft shap

Molecular BiologyBiochemistry, Genetics and Molecular Biology
10
Article|22 citations·2018
Highly Sensitive Color Tunablility by Scalable Nanomorphology of a Dielectric Layer in Liquid-Permeable Metal–Insulator–Metal Structure
Eui‐Sang Yu, Sin‐Hyung Lee, Sin‐Hyung Lee, Young-Gyu Bae, Jaebin Choi, Donggeun Lee, Chulki Kim, Taikjin Lee, Seung‐Yeol Lee, Seung‐Yeol Lee, Sin‐Doo Lee, Sin‐Doo Lee
SJR Q1ACS Applied Materials & Interfaces

A liquid-permeable concept in a metal-insulator-metal (MIM) structure is proposed to achieve highly sensitive color-tuning property through the change of the effective refractive index of the dielectric insulator layer. A semicontinuous top metal film with nanoapertures, adopted as a transreflective layer for MIM resonator, allows to tailor the nanomorphology of a dielectric layer through selective etching of the underneath insulator layer, resulting in nanopillars and hollow voids in the insula

Electronic, Optical and Magnetic MaterialsMaterials Science
11
Article|22 citations·2023
Fabry–Perot Cavity Control for Tunable Raman Scattering
Taehyun Kim, Jongsu Lee, Eui‐Sang Yu, Seung‐Ha Lee, Hyeonbin Woo, Jeonghun Kwak, Seok Chung, Inhee Choi, Yong‐Sang Ryu
SJR Q1Small

The Fabry-Perot (FP) resonator is an intuitive and versatile optical structure owing to its uniqueness in light-matter interactions, yielding resonance with a wide range of wavelengths as it couples with photonic materials encapsulated in a dielectric cavity. Leveraging the FP resonator for molecular detection, a simple geometry of the metal-dielectric-metal structure is demonstrated to allow tuning of the enhancement factors (EFs) of surface-enhanced Raman scattering (SERS). The optimum near-fi

Electronic, Optical and Magnetic MaterialsMaterials Science
12
Article|16 citations·2016
Continuity of Monolayer-Bilayer Junctions for Localization of Lipid Raft Microdomains in Model Membranes
Yong‐Sang Ryu, Nathan J. Wittenberg, Jeng-Hun Suh, Sang-Wook Lee, Youngjoo Sohn, Sang‐Hyun Oh, Atul N. Parikh, Sin-Doo Lee, Sin-Doo Lee, Sin-Doo Lee
SJR Q1Scientific ReportsOA

We show that the selective localization of cholesterol-rich domains and associated ganglioside receptors prefer to occur in the monolayer across continuous monolayer-bilayer junctions (MBJs) in supported lipid membranes. For the MBJs, glass substrates were patterned with poly(dimethylsiloxane) (PDMS) oligomers by thermally-assisted contact printing, leaving behind 3 nm-thick PDMS patterns. The hydrophobicity of the transferred PDMS patterns was precisely tuned by the stamping temperature. Lipid

Molecular BiologyBiochemistry, Genetics and Molecular Biology
13
Article|14 citations·2020
Surface Sensitive Analysis Device using Model Membrane and Challenges for Biosensor-chip
Ji Min Baek, Yong‐Sang Ryu
SJR Q1BioChip Journal
Molecular BiologyBiochemistry, Genetics and Molecular Biology
14
Article|14 citations·2003
Optical and electrical properties of in situ-annealed p-type Hg0.7Cd0.3Te epilayers grown on CdTe buffer layers for applications as infrared detectors
Yong‐Sang Ryu, Yoon-A Heo, Bo Song, Seog-Young Yoon, Y. J. Kim, Tae-Won Kang, T. W. Kim
SJR Q1Applied Physics Letters

Hall-effect, Fourier transform infrared (FTIR) transmission, and photopresponse measurements were performed to investigate the optical and electrical properties of as-grown and in situ-annealed Hg0.7Cd0.3Te epilayers grown on CdTe buffers on GaAs (211) B substrates layers by using molecular-beam epitaxy. Hall-effect measurements showed that as-grown n-Hg0.7Cd0.3Te epilayers were converted to p-Hg0.7Cd0.3Te epilayers due to in situ annealing. The carrier concentration and the mobility as function

Electrical and Electronic EngineeringEngineering
15
Review|14 citations·2022
The perspectives of broadband metasurfaces and photo‐electric tweezer applications
Geon Lee, Eui‐Sang Yu, Yong‐Sang Ryu, Minah Seo
SJR Q1NanophotonicsOA

With strong demands of real-time monitoring of biomolecules or environmental pollutants, overcoming technical hurdles on control and detection of freely diffusive nanoscale objects become a question of issue to solve in a variety of research fields. Most existing optical techniques inevitably require labeling to the target material, which sometimes denature the measuring biomaterials. For highly efficient real-time monitoring without complicated pretreatment or labeling, many successes in develo

Electronic, Optical and Magnetic MaterialsMaterials Science

Research Areas

Electrical and Electronic EngineeringBiomedical EngineeringMolecular BiologyElectronic, Optical and Magnetic MaterialsAtomic and Molecular Physics, and OpticsMaterials Chemistry

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