Yoo-Jin Park

This study was funded by Novartis Pharmaceuticals. Park and Ko are employed by Novartis Pharmaceuticals in East Hanover, New Jersey, and Ko holds stock in Novartis. Raza, George, and Agrawal are employed by Novartis Healthcare in Hyderabad, India. Study concept and design were contributed primarily by Park and Ko, along with the other authors. Raza, George, and Agrawal collected the data, along with Park and Ko. Data interpretation was performed by Agrawal, Raza, George, Park, and Ko. The manusc

We investigate regional features nearby the subway station using the clustering method called the funFEM and propose a two-step procedure to predict a subway passenger transport flow by incorporating the geographical information from the cluster analysis to functional time series prediction. A massive smart card transaction dataset is used to analyze the daily number of passengers for each station in Seoul Metro. First, we cluster the stations into six categories with respect to their patterns o

These results suggest that highly HAL-resistant cancer cells can be sensitized with cyclosporine A or elacridar, specific P-gp inhibitors that exert their effects at a low dose. These findings provide important information regarding the sensitization of highly HAL-resistant cells with selective P-gp inhibitors and indicate that elacridar may be used to treat such highly HAL-resistant cancer cells.

We investigated the relationship between oct4 gene ex-pression patterns and CpG sites methylation profiles during ES cell differentiation into neurons, and identified relevant binding factor. The oct4 gene expression level gradually declined as ES cell differentiation progressed, and the CpG sites in the oct4 proximal enhancer (PE) and promoter regions were methylated in concert with ES cell differentiation. An electro-mobility shift assay (EMSA) showed that putative proteins bind to CpG sites i

Our results, based on the NHID, supports the protective effect of tamoxifen against CVE in Korean breast cancer patients aged 55 and older that is not seen with AIs. Our results can guide the selection of adjuvant hormonal treatment agents for Korean breast cancer patients based on their risk of developing CVE.

Antimicrobial, antifungal and anti-inflammatory effects of essential oils extracted from Chamaecyparis obtusa (EOCO) have previously been reported. In the present study, the anti-inflammatory effects of EOCO were investigated in two murine models of inflammation: Carrageenan-induced paw edema and thioglycollate-induced peritonitis, and in lipopolysaccharide (LPS)-stimulated RAW 264.7 macrophage cells. The expression levels of proinflammatory cytokines were analyzed by ELISA, the expression of ni

Background Individuals increasingly turn to the Internet for health information, with YouTube being a prominent source. However, the quality and reliability of the health information vary widely, potentially affecting health literacy and behavioural intentions. Methods To analyse the impact of health information quality on health literacy and behavioural intention, we conducted a randomized controlled trial using a quality-controlled YouTube intervention. Health information quality on YouTube wa

본 연구는 메타분석 방법을 활용하여 유아 친사회적 행동 증진 프로그램의 효과를 분석하고, 프로그램을 개발하는데 필요한 기초자료를 제시하기 위한 목적으로 이루어졌다. 이를 위해 2005년부터 2015년에 발표된 국내 연구 총 48편을 수집 및 분석하였다. 연구 결과 유아의 친사회적 행동 증진 프로그램은 매우 큰 효과가 있는 것으로 나타났다. 또한, 유아 친사회적 행동의 하위요인 ‘감정이입 및 조절’에 대한 효과가 가장 큰 것으로 나타났고, 하위영역간의 효과는 유의한 차이는 없었다. 마지막으로 대상연령, 시행기간, 총 시행횟수, 주당 시행 횟수에 따라 유아 친사회적 행동 증진 프로그램의 효과 차이가 있는 것으로 나타났다. 국내 관련 연구들을 종합하여 얻어진 본 연구의 결과는 이후 연구의 질적 향상과 효과적인 현장 적용에 시사점을 제공한다는데 의의가 있다.

OBJECTIVE: To investigate the impact of retirement on marital satisfaction by gender on Koreans aged >45 years in a large, nationally representative cohort. METHODS: Retirement status and marital satisfaction data of 5867 individuals were analysed. Marital dissatisfaction was defined as a satisfaction score reduction of more than 10 points versus the previous wave. Lagged generalised estimating equation (GEE) models adjusted for demographics (age, sex, education level and household income), heal

BACKGROUND: Despite a wealth of literature on marital dissatisfaction and adverse health outcomes, little is known about the relationship between marital dissatisfaction and frailty in older adults. METHODS: This longitudinal study utilised the data of 11 174 individuals who participated in the biennial Korean Longitudinal Study of Ageing survey from 2006 to 2020 and were aged ≥45 during the initial wave. Frailty was measured using a frailty instrument, which utilised exhaustion, social isolatio

BACKGROUND: Given the rising awareness of health-related lifestyle modifications, the impact of changes in body weight (BW) on cognitive function and dementia generates significant concern. This study aimed to investigate the association between BW changes and dementia in a middle-aged Korean population. METHODS: A retrospective, population-based longitudinal study was conducted utilizing data from the National Health Insurance Service (NHIS) database. Participants aged 40 years or older in 2011