Youn Hee Lim

BACKGROUND: We aimed to investigate the effects of ambient respiratory viral infections in the general population on rheumatoid arthritis (RA) development. METHODS: Data of weekly incident RA (2012-2013) were obtained from the Korean National Health Insurance claims database, and those of weekly observations on eight respiratory viral infections were obtained from the Korea Centers for Disease Control and Prevention database. We estimated the percentage change in incident RA associated with ambi

Race and ethnicity are influential in estimating glomerular filtration rate (GFR). We aimed to find the Korean coefficients for the Modification of Diet in Renal Disease (MDRD) study equations and to obtain novel proper estimation equations. Reference GFR was measured by systemic inulin clearance. Serum creatinine (SCr) values were measured by the alkaline picrate Jaffé kinetic method, then, recalibrated to CX3 analyzer and to isotope dilution mass spectrometry (IDMS). The Korean coefficients fo

Background: We aimed to evaluate the spatial and temporal trends of the health burden attributable to particulate matter less than 2.5 µm in diameter (PM2.5) in the metropolitan cities and provinces of the Korea. Methods: We used modeled PM2.5 concentration data for the basic administrative levels, comprising the cities and the provinces of Korea, the corresponding annual population census data for each level, and the age and cause specific mortality data. We applied cause- specific integrated e

Our analysis suggested that low-level of pyrethroid exposure has positive association with BMI, however, there is an inverse relationship above the urinary 3-PBA level at 4 ug/g creatinine.

OBJECTIVE: To review past and present management of congenital adrenal hyperplasia at a single centre, as a guide to best practice. METHODOLOGY: The records of 89 patients with congenital adrenal hyperplasia due to 21-hydroxylase deficiency managed in a children's hospital in Australia over a period of 25 years were reviewed. RESULTS: The diagnosis was made in infancy in 66 patients (37 males and 29 females) and later in 23 (11 males and 12 females). The mean age for genitoplasty in females with

The purpose of current study was to investigate associations of serum 25-hydroxyvitamin D (OHVD) levels with markers for metabolic syndrome in elderly Koreans. We conducted a panel study on 301 individuals over 60 yr old in Seoul, Korea, and repeatedly measured serum OHVD, glucose, insulin, and lipid levels. Mixed effect model and generalized estimating equations were used to investigate relationships between serum OHVD levels with marker levels for metabolic syndrome and each of its categories.

Payday loans refer to small-dollar, high-interest, short-term loans usually extended to lower-income consumers. Despite much research to the contrary, the payday loan industry asserts that it primarily serves middle-class Americans. This article discusses the authors' investigation of the industry's claim, by analyzing data from a U.S. bankruptcy court serving a Southern district. Results of the multivariate binary logistic regression analysis showed that, controlling for various sociodemographi

Cystatin C reflects kidney dysfunction sensitively, and thus cystatin C-based estimation of GFR could provide a reliable support for clinical practice.

Objectives: The impact of climate change on the health has been of increasing concern due to a recent temperature increase and weather abnormality, and the research results of the impact varied depending on regions. We synthesized risk estimates of the overall health effects of low and high temperature taking account of the heterogeneity. Methods: A comprehensive literature search was conducted using PUBMED to identify journal articles of low and/or high temperature effects on mortality. The sea

CONTEXT: Early menarche within the general population has previously been linked to increased risk of mental health disorders, and such associations are likely to be even stronger in children diagnosed with extremely early puberty (precocious puberty); however, information is sparse. OBJECTIVE: Investigate the association between precocious puberty and psychiatric disorders. DESIGN: A large cohort study included individuals in the National Danish Patient Registry with a diagnosis of precocious p

OBJECTIVES: The study was designed to assess the reliability of measurement of 24-hour urinary 17 alpha-hydroxyprogesterone (17-OHP) by radio-immunoassay (RIA) as an alternative biochemical assessment for monitoring the treatment of congenital adrenal hyperplasia (CAH) due to 21-hydroxylase deficiency (21-OHD) and to assess the need for sample purification by column chromatography to improve assay specificity. METHODOLOGY: Morning serum 17-OHP was measured using RIA and 24-hour urinary pregnanet

본 연구는 국민건강영양조사 제4기와 제5기(2007년∼ 2012년) 자료를 이용하였으며, 구강검진 조사자료가 제공되지 않은 2011년 자료를 제외하고, 20세 이상의 성인11,643명을 대상으로 연도별 흡연 유형별 치주질환의 추이를 살펴보고, 치주질환에 영향을 주는 인자를 평가하였다. 5개년도를 통합한 자료에서는 비흡연자에 비해 직접흡연자는단순, 다중 로지스틱 회귀분석 모두에서 치주질환이 있을aOR이 1.78, 1.77이었으며(p＜0.001), 연도별 경향성을 보았을 때, 여자에 비해 남자가 치주질환이 있을 aOR은 1.12 로 나타났다(p＜0.001). 연도별 흡연 유형에 따라 치주질환유병률은 치주질환이 있는 집단에서 직접흡연자의 비율이현저하게 증가추세를 보였다. 또한 주요인자를 보정한 연도별 흡연 유형과 치주질환의 관련성을 단변량 분석한 결과, 비흡연자에 비해 직접흡연자의 치주질환이 있을 aOR은2007년도에 1.99로 가장 높게 나타났다. 반면에 간접흡연자가 비흡연자에 비해 치

Objectives: Previous epidemiological studies about oxidative stress and depression are limited by hospital-based case-control design, single-time measurements of oxidative stress biomarkers, and the small number of study participants. Therefore, in this study, we analyzed the association between biomarker of oxidative stress and depressive symptom scores using repeatedly measured panel data from a community-dwelling elderly population. Methods: From 2008 to 2010, a total of 478 elderly participa

목적: 최근 중금속과 인지기능 혹은 치매에 관련된 연구가 많이 늘었지만 아직까지 카드뮴이 인지기능에 미치는 영향에 대해서는 연구 결과가 일관되지 못하고 생물학적 기전도 명확하게 밝혀져 있지 않아 확정적인 결론을 내기에는 어려운 수준이다. 그래서 저자들은 노령인구에서 카드뮴이 인지기능에 미치는 영향에 대한 보다 명확한 근거를 제시하고자 본 연구를 수행하였다. 방법: 본 연구는 노령인구의 환경노출에 의한 건강영향조사 (Korean Elderly Environmental Panel Study, KEEPS)의 일부분으로 2008년 8월 26일부터2010년 8월 20일 까지 서울시 성북구 치매지원센터와 길음 복지관에 방문하여 환경오염노출 조사와 건강검진을 받은 403명을 대상으로 혈중 카드뮴 농도 측정, MMSE-KC, K-FAQ등을 측정, 평가하였다. 성별, 나이, 학력, 흡연습관과 음주습관을 보정하여 다중회귀분석을 실시하였다. 또한 성별, 교육수준, 흡연습관, 음주습관에 따른 혈중 카드뮴

In this paper, we introduce a hierarchical Bayesian model to simultaneously estimate the thresholds of each 6 cities. It was noted in the literature there was a dramatic increases in the number of deaths if the mean temperature passes a certain value (that we call a threshold). We estimate the difference of mortality before and after the threshold. For the hierarchical Bayesian analysis, some proper prior distribution of parameters and hyper-parameters are assumed. By combining the Gibbs and Met