Young Seon Hong

OBJECTIVE: The aim of this study was to explore the prevalence and pattern of the metabolic syndrome and its association with hyperinsulinemia in an urban Korean population of 269 men and 505 women. RESEARCH DESIGN AND METHODS: The National Cholesterol Education Program Adult Treatment Panel (ATP) III guidelines were used to calculate the sex-specific prevalence of the metabolic syndrome. After excluding individuals taking medication for hypertension, diabetes, or dyslipidemia, we used factor an

The role of glutamatergic system in the neurobiology of mood disorders draws increasing attention, as disturbance of this system is consistently implicated in mood disorders including major depressive disorder and bipolar disorder. Thus, the glutamate hypothesis of mood disorders is expected to complement and improve the prevailing monoamine hypothesis, and may indicate novel therapeutic targets. Since the contribution of astrocytes is found to be crucial not only in the modulation of the glutam

BACKGROUND: Epicardial adipose tissue (EAT) is suggested to play an important role in the progression of metabolic syndrome. We aimed to establish a simple method to measure EAT and examine the differences in EAT thickness according to the presence of type 2 diabetes mellitus or obesity. METHODS: A total of 94 patients (42.6% type 2 diabetes mellitus, 53.2% obese, mean age 61±13) who underwent multidetector computed tomography were enrolled. Thickness of EAT was measured on the parasternal short

Constipation and the use of laxatives are relatively common in patients with diabetes mellitus. However, the mechanisms responsible for the constipation are unclear. Even though autonomic neuropathy is regarded as one of the important mechanisms of constipation, it requires further clarification. In addition, the colonic function in diabetic patients requires further investigation. The aim of this study was to compare the colonic transit time between patients with diabetes mellitus and healthy s

This study showed that being overweight or obese during preadolescence is associated with a higher risk of metabolic syndrome and is related to unhealthy eating behaviors. Thus, weight-control strategies and healthy eating behaviors should be developed early in life to reduce the risk for metabolic syndrome.

Atypia of undetermined significance/follicular lesion of undetermined significance (AUS/FLUS) in thyroid fine needle aspiration (FNA) is a challenging category. The malignancy risk is different by multiple factors and subsequent management strategy is inconclusive. Therefore, we analyzed the malignancy risk of AUS/FLUS according to radiological and clinical features. A total of 687 nodules that had been initially diagnosed as AUS/FLUS were retrospectively reviewed from 6365 thyroid FNAs between

BACKGROUND: Since patients with type 2 diabetes mellitus (T2DM) have an increased risk of cardiovascular events, interventions addressing risk factors reduce the incidence of cardiovascular disease (CVD) events. This study aimed to evaluate the difference in the incidence of CVD events according to risk factor control in patients with diabetes with and without cardio-renal disease. METHODS: We analyzed 113,909 patients with diabetes and 290,339 without diabetes using data released by the Nationa

BACKGROUND: Cardiovascular disease is the leading cause of morbidity and mortality in postmenopausal women. Early menarche may be associated with an increased risk of metabolic diseases such as diabetes and cardiovascular disease. This study aimed to investigate the effect of menarche age and the risk of diabetes and metabolic syndrome in Korean postmenopausal women. METHODS: We analyzed 4,933 postmenopausal women (mean age: 64.7 years) using the Korean National Health and Nutritional Examinatio

이상지질혈증은 흔히 다른 질환과 함께 존재한다. 그 중 일부는 지질 이상에 의해 유발되는 합병증이며, 때로는 지단 백 대사에 영향을 미치는 질환에 의해 이상지질혈증이 동반 되기도 한다. 후자의 경우 이차성 이상지질혈증으로 분류되 는데, 콜레스테롤이나 중성지방의 증가 또는 복합 고지혈증 이 나타날 수 있으며 고밀도 지단백(high-density lipoprotein, HDL)의 저하가 동반되기도 한다. 이차성 이상지질혈증의 경우에도 심혈관질환의 위험성 증가와 관련되며 원발성 질 환의 치료는 지질 대사의 호전을 가져온다. 따라서 이상지질 혈증을 진단하고 치료할 때 이차적으로 지질 대사 이상을 가져올 수 있는 요인들에 대한 고려가 필요하다. 당뇨병, 대 사증후군, 갑상선 질환, 뇌하수체 질환, 호르몬제의 투여나 임신 등 내분비질환 또는 호르몬의 변화는 이차성 이상지질 혈증을 일으키는 주요 원인 중의 하나이다[1~4].

BACKGROUND: Bisphenol A (BPA) is a type of endocrine-disrupting chemical utilized in the production of plastics like epoxy resins and polycarbonate polymers. BPA exhibits weak estrogenic and potent anti-androgenic effects, and prior research has linked it to disturbances in thyroid function. This study aims to assess the potential association between early childhood exposure to urinary bisphenol A and thyroid hormone levels in pubertal children from Korea. METHODS: Participants were drawn from t

Disclosure of a diagnosis of cancer to patients is a major problem among physicians in Korea. Many questions arise when considering issues involved in telling the diagnosis of cancer beyond the question of whether to tell. But there has been no consensus guideline on how, and in what context, to tell the diagnosis of cancer to the patients. The review of the literature reveals that the attitudes of physicians on the truth telling have been changing from favoring non-disclosure to disclosure over