[论文解读] Temporally resolved aortic 3D shape reconstruction from a limited number of cine 2D MRI slices

Gloria Wolkerstorfer, Stefano Buoso+4 more|arXiv (Cornell University)|Feb 12, 2026

Aortic Disease and Treatment Approaches被引用 0

一句话总结

本论文展示了通过将统计形状模型与可微分体积网格优化相耦合，在仅需六幅 cine 2D MRI 切片的情况下实现个体特异性主动脉几何形状的时间分辨三维重建，并以4D flow MRI参考数据进行验证。

ABSTRACT

Background and Objective: We propose a shape reconstruction framework to generate time-resolved, patient-specific 3D aortic geometries from a limited number of standard cine 2D magnetic resonance imaging (MRI) acquisitions. A statistical shape model of the aorta is coupled with differentiable volumetric mesh optimization to obtain personalized aortic meshes. Methods: The statistical shape model was constructed from retrospective data and optimized 2D slice placements along the aortic arch were identified. Cine 2D MRI slices were then acquired in 30 subjects (19 volunteers, 11 aortic stenosis patients). After manual segmentation, time-resolved aortic models were generated via differentiable volumetric mesh optimization to derive vessel shape features, centerline parameters, and radial wall strain. In 10 subjects, additional 4D flow MRI was acquired to compare peak-systolic shapes. Results: Anatomically accurate aortic geometries were obtained from as few as six cine 2D MRI slices, achieving a mean +/- standard deviation Dice score of (89.9 +/- 1.6) %, Intersection over Union of (81.7 +/- 2.7) %, Hausdorff distance of (7.3 +/- 3.3) mm, and Chamfer distance of (3.7 +/- 0.6) mm relative to 4D flow MRI. The mean absolute radius error was (0.8 +/- 0.6) mm. Significant age-related differences were observed for all shape features, including radial strain, which decreased progressively ((11.00 +/- 3.11) x 10-2 vs. (3.74 +/- 1.25) x 10-2 vs. (2.89 +/- 0.87) x 10-2 for young, mid-age, and elderly groups). Conclusion: The proposed method enables efficient extraction of time-resolved 3D aortic meshes from limited sets of standard cine 2D MRI acquisitions, suitable for computational shape and strain analysis.

研究动机与目标

• 评估在有限的 cine 2D MRI 切片集合下，重建时间分辨、三维、个体特异性主动脉几何的可行性。
• 评估重建相对于4D flow MRI参考的准确性，并分析几何描述量与径向应变在不同受试者中的变化。
• 识别最佳的 cine 切片放置位置并在志愿者及主动脉瓣狭窄患者的在体数据上进行验证。

提出的方法

• 手动分割 Cine 2D MRI 切片。
• 利用受统计形状模型约束的可微分网格优化来重建三维几何。
• 在体内实验前先在合成数据上评估最佳切片放置位置，涉及30名受试者。
• 从时间分辨几何形状中推导几何描述量与径向应变。
• 在一个子集（n=10）中，与4D flow MRI参考进行峰值收缩期形状比较。

实验结果

研究问题

• RQ1 能否从有限数量的 Cine 2D MRI 切片中准确重建时间分辨的、个体特异性的三维主动脉几何？
• RQ2 在峰值收缩期相对于4D flow MRI参考的重建准确性如何？
• RQ3 重建的主动脉在几何描述量与径向应变方面是否随年龄组而变化？

主要发现

Metric	Value (Mean ± SD)
Dice vs 4D flow reference	89.9% ± 1.6%
IoU vs 4D flow reference	81.7% ± 2.7%
Hausdorff distance	7.3 mm ± 3.3 mm
Chamfer distance	3.7 mm ± 0.6 mm
Mean absolute radius error (aortic arch)	0.8 mm ± 0.6 mm

• 使用少至六幅 cine 2D MRI 切片即可实现准确重建。
• 与4D flow参考的 Dice 得分：89.9% ± 1.6%；IoU：81.7% ± 2.7%；Hausdorff：7.3 mm ± 3.3；Chamfer：3.7 mm ± 0.6。
• 主动脉弓处的平均绝对半径误差为 0.8 mm ± 0.6。
• 在年轻、中年、老年组中观察到几何特征和径向应变的显著年龄相关差异；径向应变随年龄下降（数值：11.00e-3 ± 3.11e-3、3.74e-3 ± 1.25e-3、2.89e-3 ± 0.87e-3）。
• subset（n=10）中的四维流MRI为峰值收缩期形状比较提供参考。