Arvind K. Singh Chandel

The low water solubility of pharmacoactive molecules limits their pharmacological potential, but the solubility parameter cannot compromise, and so different approaches are employed to enhance their bioavailability. Pharmaceutically active molecules with low solubility convey a higher risk of failure for drug innovation and development. Pharmacokinetics, pharmacodynamics, and several other parameters, such as drug distribution, protein binding and absorption, are majorly affected by their solubi

Postoperative peritoneal adhesion (PPA) is a prevalent incidence that generally happens during the healing process of traumatized tissues. It causes multiple severe complications such as intestinal obstruction, chronic abdominal pain, and female infertility. To prevent PPA, several antiadhesion materials and drug delivery systems composed of biomaterials are used clinically, and clinical antiadhesive is one of the important applications nowadays. In addition to several commercially available mat

We synthesized agarose-polycaprolactone (Agr-PCL) bicomponent and Agr-polyethylene glycol-PCL (Agr-PEG-PCL) tricomponent amphiphilic co-network (APCN) gels by the sequential nucleophilic substitution reaction between amine-functionalized Agr and activated halide terminated PCL or PCL-b-PEG-b-PCL copolymer for the sustained and localized delivery of hydrophilic and hydrophobic drugs. The biodegradability of the APCNs was confirmed using lipase and by hydrolytic degradation. These APCN gels displa

Key issues of injectable hydrogels are incapability of loading hydrophobic drugs due to insolubility of drugs in aqueous prepolymer solution as well as in hydrogel matrix, and high water swelling, which leads to poor mechanical and bioadhesive properties. Herein, we report that self-assembly of partially long-chain alkylated dextran- graft-poly[(2-dimethylamino)ethyl methacrylate] copolymer in aqueous solution could encapsulate pyrene, a hydrophobic probe, griseofulvin, a hydrophobic antifungal

Rapid gelation, low heat generation, biocompatibility, biodegradability, avoiding the use of a small molecular weight gelator and high gel fraction are the essential criteria for the successful biomedical application of an injectable hydrogel. We have developed a series of dually crosslinked injectable hydrogels of PEG and poly[2-(dimethylamino)ethyl methacrylate]-b-poly(N-isopropyl acrylamide) through extremely simple chemistry. The sequential nucleophilic substitution reaction between PEG cont

The advent of e-resources and their increased use have changed the library scenario from physical to virtual. Users’ preferences are more for e-resources and virtual libraries with little attraction for physical libraries. In spite of innumerable advantages of e-resources, there are certain problems also relating to their acquisition, maintenance, management, etc. which need collaborative efforts of professionals and all other bodies associated with creation, distribution and use of these resour

The low water solubility of any pharmacoactive molecules limits their pharmacological potential but the solubility parameter cannot compromise, so different approaches are employed to enhance their bioavailability. Pharmaceutically active molecules with low solubility convey a higher risk of failure for drug innovation and development. Pharmacokinetics, pharmacodynamics, and several other parameters, such as drug distribution, protein binding and absorption, are majorly affected by their solubil

The herbal-based drugs have been getting wide attention over the last few decades. The herbal drugs have been used from the ancient times, but the dose accuracy, efficacy, and treatment was just based on symptomatic observatory. Modern research is focused on pure bioactive compound instead of crude. The researchers are trying to apply the current advanced nanotechnology-based knowledge on the herbal medicines to improve efficacy and reduces the unwanted pharmacological actions' adverse effects o

This chapter presents novel, multi-component amphiphilic polymer co-networks (APCNs), which, in addition to the hydrophilic, typically poly(ethylene glycol) or poly[(2-dimethylamino)ethyl methacrylate], and hydrophobic, typically poly(e-caprolactone), polymeric components, a hydrophilic polysaccharide is also incorporated. These polysaccharides are agarose and dextran. The biocompatibility and biodegradability of the APCNs are investigated, as well as their drug loading capacity and release beha

In the present study, we report the first synthesis of diazirine-modified hyaluronic acid (HA-DAZ). In addition, we also produced a precursor polymer solution composed of HA-DAZ and dendritic polyethyleneimine (DPI) that showed strong shear-thinning properties. Furthermore, its viscosity was strongly reduced (<i>i.e.</i>, from 5 × 10⁵ mPa s at 10^-3 s^-1 to 6 × 10¹ mPa s at 10³ s^-1), substantially, which enhanced solution injectabil

This paper discusses that cataloguing continues to be basic tool of knowledge organisation whichhas taken over even the function of classification bringing together similar ideas accessible on multiplepoints. It traces the history of cataloguing and individual contributions made by Panizzi, Lubetzky, Cutter,and Ranganathan who laid the foundation for modern cataloguing. It discusses the background ofResource Description and Access (RDA) code as development over AACR-2. The conceptual model of Fu