The University of Osaka · Medicine
Professor Atsunari Kawashima's research lab specializes in translational oncology, focusing on the tumor immune microenvironment and predictive biomarkers in urological cancers, particularly renal cell carcinoma (RCC) and muscle-invasive bladder cancer (MIBC). The lab investigates T cell exhaustion, regulatory T cell dynamics, and systemic inflammatory markers to identify novel prognostic and predictive factors for treatment response and survival. Their work integrates molecular profiling, including RNA sequencing and gene set enrichment analysis, with clinical outcomes to guide personalized therapy strategies.
Figures are computed from collected data and may differ slightly.
Although further study is needed, ERCC1 expression level may predict the efficacy of CRT for MIBC.
It is important to evaluate the clinical importance of both CD8 T cells and CD4 T cells expression simultaneously because they have crucial networks in tumour targeting immune responses. In 97 RCC patients, RNA sequencing and gene set enrichment analysis of both CD8 and CD4 T cells based on the expression levels of PD-1 and TIM-3 implied that the populations of PD-1+TIM-3+ CD8 T cells and PD-1lowTIM-3 + CD4 T cells were characterized as exhausted CD8 T cells and regulatory CD4 T cells, respectiv
Hyponatremia (<138 mEq/L), neutrophilia and high C-reactive protein levels seem to represent significant predictive factors for cancer-specific survival in metastatic renal cell carcinoma patients treated with molecular targeted therapy as first line therapy. Furthermore, hyponatremia might be significantly associated with chronic inflammation and tumor aggressiveness.
Sorafenib was effective in Japanese patients with advanced renal cell carcinoma in general clinical practice and was tolerated although most patients required dose reduction or interruption of therapy. Future studies should establish new strategies for treatment without sacrificing both efficacy and patient quality of life.
The expression of CD4+CD8+ T cells was significantly up-regulated in RCC patients and correlated significantly with prognostic importance in surgically treated RCC patients.
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