Yonsei University · Medicine
Professor Byoung Seok Ye's research lab specializes in the neuroimaging and biomarker-based investigation of neurodegenerative diseases, particularly Alzheimer’s disease (AD) and small vessel disease (SVD). The lab focuses on understanding the longitudinal progression of mild cognitive impairment (MCI), with particular emphasis on the interplay between amyloid pathology, cerebrovascular burden, and metabolic factors such as uric acid and body mass index (BMI). Using multimodal imaging (PET, MRI) and cerebrospinal fluid biomarkers, the lab aims to identify early prognostic indicators and distinct neurodegenerative phenotypes in at-risk populations.
Figures are computed from collected data and may differ slightly.
In SVaD patients, amyloid burden, independently or interactively with SVD, contributed to longitudinal cognitive decline. Amyloid deposition was the strongest poor prognostic factor.
Higher levels of uric acid had protective effects on longitudinal cognitive decline independent of and interactively with CSF AD biomarkers.
We aimed to compare the longitudinal outcome of amnestic mild cognitive impairment (aMCI) patients with significant Pittsburgh Compound B uptake [PiB(+) aMCI] and those without [PiB(-) aMCI]. Cerebral β-amyloid was measured in 47 patients with aMCI using PiB-positron emission tomography (PET) (31 PiB(+) aMCI and 16 PiB(-) aMCI). Clinical (N = 47) and neuropsychological follow-up (N = 37), and follow-up with brain magnetic resonance imaging (N = 38) and PiB-PET (N = 30) were performed for three y
Our findings suggest that E-aMCI might represent an early symptomatic stage of AD. Furthermore, L-aMCI might resemble AD more closely than E-aMCI, in terms of the topography of cortical thinning.
Our findings suggested that underweight at baseline was associated with a higher risk of progression to pADD, while obesity at baseline predicted a lower risk. Furthermore, significant changes in BMI during the follow-up period reflected an increased risk of progression to pADD, regardless of BMI status at baseline.
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