Yonsei University · Medicine
Professor Chang Ook Park's research lab focuses on understanding the immunological and molecular mechanisms underlying atopic dermatitis (AD) and related atopic diseases, with an emphasis on identifying key biomarkers and immune cell interactions that drive disease progression. The lab investigates the roles of specific cytokines, chemokines (such as CCL18), and immune cells—including dendritic cells, ILCs, and iNKT cells—in shaping the inflammatory microenvironment in AD subtypes. Additionally, the lab explores novel diagnostic and therapeutic strategies, including immunotherapy using allergens and innovative molecular probes for cancer imaging, highlighting a translational approach bridging basic immunology and clinical applications.
Figures are computed from collected data and may differ slightly.
Under decreased levels of ceramide in AD patients with HND, <i>M. furfur</i> would proliferate, which may enhance pro-inflammatory cytokine levels, angiogenesis, and tissue remodeling. Thus, it plays a central role in the pathogenesis of HND in AD.
This study suggests that the chemokine micromilieu, especially the level of CCL18, is different between EAD and IAD patients. High FcepsilonRI surface-expressing DCs, such as IDEC, were the major source of CCL18, and produced a prominent CCL18 microenvironment in EAD patients compared with IAD patients.
Atopic dermatitis (AD) is the most common form of chronic skin inflammation with diverse clinical variants. Historically, various AD phenotypes have been grouped together without considering their heterogeneity. This approach has resulted in a lack of phenotype- and endotype-adapted therapeutic strategies. Comprehensive insights into AD pathogenesis have enabled precise medicinal approach for AD. These efforts aimed to redefine the endophenotype of AD and develop various biomarkers for diverse p
Atopic dermatitis (AD) is a highly pruritic, chronic relapsing inflammatory skin disease characterized by innate and adaptive immune reactions. In AD, innate immune mechanisms such as pattern recognition receptors and antimicrobial peptides have been investigated in detail, but recently, epidermis-derived cytokines, namely thymic stromal lymphopoietin (TSLP), IL-25 and IL-33, were shown to participate in innate immune reactions independently of adaptive immunity. In addition to conventional inna
In this investigation, a new terpyridine metal complex was developed as a probe for selective detection of ATP and imaging of melanoma cells. The probe takes advantage of the ability of the metal complex to be transformed to its imaging competent turn-on state through assembly with ATP.
Although a larger number of patients for a longer follow-up period are needed to precisely assess the treatment efficacy, AIT using cat and/or dog dander may be an effective treatment option for AD patients, especially for severe AD patients with other respiratory allergic comorbidities who cannot completely avoid the exposure to animal dander.
Transdermal drug delivery systems (TDDSs) overcome the hurdle of an intact skin barrier by penetrating the skin to allow molecules through. These systems reduce side effects associated with conventional hypodermic needles. Here, we introduce novel microneedle (MN) TDDSs that enhance drug delivery by creating micron-sized pores across the skin. Many MN TDDSs designed to deliver a diverse array of therapeutics, including allergen-specific immunotherapy, skin disease treatments, and vaccines, are u
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