Sungkyunkwan University · Medicine
Professor Changwon Kee's research lab specializes in glaucoma pathophysiology, with a focus on normal-tension glaucoma (NTG) and juvenile-onset open-angle glaucoma (JOAG). The lab investigates the interplay between optic nerve damage, peripapillary microvasculature, and intraocular pressure regulation, using advanced imaging and clinical assessments to understand disease progression and treatment responses. Key research directions include the role of vascular compromise in NTG, surgical techniques in glaucoma drainage devices, and the impact of anatomical factors like optic disc size on diagnostic interpretation.
Figures are computed from collected data and may differ slightly.
The partial ligation of a tube in Ahmed glaucoma valve implantation suggested a lower rate of hypotony and surgical complications. There was no significant difference in final success rate between the partial ligation and nonligation groups.
PPG eyes and normal eyes were found to have the similar densities of peripapillary microvasculature at the area with nerve fiber layer defect, whereas in PG eye, there was a significant decrease in vessel density at the area of RNFL thinning. This provides evidence that microvascular compromise in the retina might be a secondary change to nerve fiber layer degeneration in the pathogenesis of NTG.
Because patients with considerable JOAG had no definite symptoms, periodic eye examinations are needed. To prevent the VF's progression, JOAG patients may require more careful management of intraocular pressure.
cGMP may be involved in the regulation of aqueous humor formation and outflow facility and their responses to pharmacologic agents.
Optic disc size, but not age, should be considered in the interpretation of optic disc variables.
Stromelysin, a functional gene, can be transferred in vivo into rat eyes and in vitro into cultured human trabecular cells using a replication-deficient adenovirus vector. This shows the possibility of gene therapy in glaucoma.
To identify TIGR gene mutation in two Korean pedigrees of primary open-angle glaucoma (POAG), and in 25 steroid-induced glaucoma patients, TIGR gene assay was performed. Genomic DNA was extracted from peripheral blood and the TIGR gene was amplified by polymerase chain reaction (PCR). The PCR amplification products were evaluated by single-stranded conformation polymorphism and direct DNA sequencing. In POAG families, not only those patients clinically diagnosed as glaucoma, but also most of the
Episcleral application of mitomycin C can produce at least a modest short-term reduction of aqueous humor flow in primates. Reduced aqueous flow might contribute to early postoperative hypotony following trabeculectomy with mitomycin C.
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