Yonsei University · Medicine
Professor Chi Young Shim's research lab focuses on cardiovascular pathophysiology, particularly the mechanisms underlying heart failure with preserved ejection fraction (HFpEF) and atherosclerotic cardiovascular disease. The lab investigates hemodynamic responses during exercise, such as exercise-induced pulmonary hypertension and left ventricular filling pressure dynamics, to identify prognostic markers and pathophysiological pathways. It also explores molecular mechanisms involving receptors like RAGE and platelet-endothelial interactions in vascular inflammation and early atherosclerosis. Recent work includes clinical trials evaluating cardioprotective effects of SGLT2 inhibitors like dapagliflozin on left ventricular diastolic function in diabetic patients.
Figures are computed from collected data and may differ slightly.
Exercise-induced PH provides prognostic information in subjects with preserved LV ejection fraction. The excess risk of exercise-induced PH is restricted to subjects with an increase in estimated LV filling pressure during exercise.
RAGE is pattern recognizing receptors for diverse endogenous ligands. RAGE activation by RAGE ligands is known to be associated with reactive oxygen species generation, activation of NF kappa B, as well as recruitment of proinflammatory cells. Activated endothelial cells, vascular smooth muscle cells in atherosclerotic plaques and activated inflammatory cells all have increased expression of RAGE, which with its interaction with RAGE ligands increases the secretion of proinflammatory cytokines a
Platelet-endothelial interactions occur in early atherosclerosis. These interactions are in part caused by endothelial von Willebrand factor large multimers, which can be reversed with exogenous ADAMTS13.
title: Randomized, Controlled Trial to Evaluate the Effect of Dapagliflozin on Left Ventricular Diastolic Function in Patients With Type 2 Diabetes Mellitus: The IDDIA Trial, doi: 10.1161/CIRCULATIONAHA.120.051992, category: Article
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