Tohoku University · Medicine
Professor Cong Huang's research lab focuses on the genetic and molecular mechanisms underlying complex agronomic traits in upland cotton (Gossypium hirsutum), utilizing genome-wide association studies and high-throughput genotyping to identify key genetic variants. The lab also investigates the roles of microRNAs in cellular processes such as osteoblast differentiation and proliferation in mesenchymal stem cells, contributing to bone biology and regenerative medicine. Additionally, the lab explores the epidemiological links between metabolic factors—like uric acid levels—and human health outcomes, including muscle strength and mental health. These interdisciplinary efforts bridge plant genetics, molecular biology, and human health research.
Figures are computed from collected data and may differ slightly.
Gossypium hirsutum L. represents the largest source of textile fibre, and China is one of the largest cotton-producing and cotton-consuming countries in the world. To investigate the genetic architecture of the agronomic traits of upland cotton in China, a diverse and nationwide population containing 503 G. hirsutum accessions was collected for a genome-wide association study (GWAS) on 16 agronomic traits. The accessions were planted in four places from 2012 to 2013 for phenotyping. The CottonSN
This population-based cross-sectional study shows for the first time that hyperuricemia is associated with poor muscle strength. Moreover, the results indicate an inverted J-shaped association between serum UA quartiles and muscle strength.
Despite extensive research on osteoblast differentiation and proliferation in mesenchymal stem cells (MSCs), the accurate mechanism remains to be further elucidated. MicroRNAs have been reported to be key regulators of osteoblast differentiation and proliferation. Here, we found that miR-144-3p is down-regulated during osteoblast differentiation of C3H10T1/2 cells. Overexpression of miR-144-3p inhibited osteogenic differentiation, whereas inhibition of miR-144-3p reversed this process. Furthermo
This prospective study is the first to reveal the combined relationship between unhealthy eating and the incidence of depressive symptoms.
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