东京大学、京都大学、大阪大学等日本QS前10名大学的研究室信息。
Professor Junken Aoki's research lab specializes in lipid signaling, with a primary focus on the enzymology and physiological roles of autotaxin (ATX) and its product, lysophosphatidic acid (LPA). The lab investigates the biosynthesis, metabolism, and receptor-mediated actions of bioactive lipids, particularly in the context of vascular development, cancer progression, and inflammation. Using genetic models, biochemical assays, and advanced lipidomics techniques, the lab elucidates the structure-activity relationships of LPA receptors and develops innovative methods for lipid detection and quantification. Their work has significantly advanced understanding of how lipid mediators regulate cell migration, angiogenesis, and disease pathogenesis.
Professor Mototsugu Shintani's research lab specializes in econometric theory, time series analysis, and macroeconomic modeling with a focus on nonlinear dynamics, unit root testing, and business cycle fluctuations. The lab investigates complex economic phenomena such as news shocks, nonlinear adjustment in exchange rates, and chaotic behavior in macroeconomic time series using advanced statistical and computational methods. A central theme is the development of robust econometric techniques—particularly nonparametric and semiparametric methods—for detecting structural changes, nonlinear trends, and long-memory properties in economic data. The lab's work bridges theoretical econometrics with empirical macroeconomic applications, especially in the context of U.S. and Japanese economies.
Professor Ryosuke O. Tachibana's research lab specializes in the neuroethology and computational analysis of complex sequential vocal behaviors in animals, with a primary focus on birdsong and rodent ultrasonic vocalizations. The lab develops advanced signal processing and machine learning techniques to decode the temporal and spectral structures of animal vocalizations, aiming to uncover the neural mechanisms underlying vocal plasticity, context dependency, and learning. By integrating behavioral experiments with modern deep learning models and acoustic analysis, the lab investigates how animals produce and process complex sequences, offering insights into the principles of sequential behavior and their neural basis.
Professor Jun-ichi Maruyama's research lab focuses on cellular and molecular biology of filamentous fungi, particularly *Aspergillus oryzae*, with an emphasis on organelle dynamics, protein trafficking, and subcellular compartmentalization. The lab investigates peroxisomal functions beyond fatty acid oxidation, including roles in fungal development and stress responses, and explores the mechanisms of nuclear distribution and cell cycle regulation in hyphal growth. Using advanced live-cell imaging and genetic tools such as GFP-tagged proteins and FACS analysis, the lab uncovers fundamental principles of organelle organization and secretion in eukaryotic cells.
Professor Genta Okude's research lab focuses on the evolutionary developmental biology and molecular genetics of Odonata (dragonflies and damselflies), with a particular emphasis on metamorphosis, coloration mechanisms, and sex-specific polymorphisms. The lab integrates genomics, histology, and experimental rearing to uncover molecular pathways underlying dramatic life-stage transitions and diverse visual signals in these ancient insects. A key goal is establishing functional genetic tools in Odonata, overcoming challenges like poor RNAi efficiency, to enable deeper mechanistic studies. The lab also investigates host-symbiont interactions, particularly in insect-bacterium associations with reduced genomes and morphological adaptations.
Professor Hyun Jin Kim's research lab specializes in the design and development of advanced nanocarriers for nucleic acid-based therapeutics, with a primary focus on siRNA and mRNA delivery for cancer and neurodegenerative diseases. The lab pioneers stimuli-responsive, smart polymeric and hybrid nanostructures—particularly pH- and redox-responsive systems—engineered for enhanced tumor targeting, endosomal escape, and biocompatibility. Key innovations include size-controlled, reversible nanoassemblies and polyplex systems that optimize pharmacokinetics and cellular delivery efficiency.
Professor Hiroko Yamada's research lab specializes in the design and synthesis of advanced organic semiconductors and photoactive materials for next-generation optoelectronic devices. Her group focuses on molecular engineering of porphyrin-based systems, fullerenes, and acenes to enable efficient light harvesting, charge separation, and transport—key processes in artificial photosynthesis and organic field-effect transistors (OFETs). They develop solution-processable small molecules and functional materials with tailored optoelectronic properties, emphasizing applications in low-cost, flexible electronics and renewable energy conversion.
Professor Yuhei Miyauchi's research lab specializes in the optical and electronic properties of low-dimensional nanomaterials, with a primary focus on single-walled carbon nanotubes (SWNTs) and transition metal dichalcogenides (TMDs). The lab investigates excitonic phenomena, including exciton-phonon interactions, valley dynamics, and anisotropic optical responses, using advanced spectroscopic techniques such as polarized photoluminescence, time-resolved spectroscopy, and isotope engineering. Their work reveals fundamental insights into quantum confinement effects, non-radiative relaxation pathways, and light-matter interactions in 1D and 2D nanomaterials, with implications for next-generation optoelectronic and valleytronic devices.
Professor Soyoung Park's research lab specializes in the development of DNA-based hybrid catalysts for enantioselective organic synthesis, focusing on merging the structural versatility of DNA with the catalytic power of transition metal complexes. The lab pioneers innovative strategies for covalent integration of metal-binding ligands into DNA backbones, enabling precise control over stereochemistry and reactivity in key transformations such as Friedel-Crafts alkylation and Diels-Alder reactions. A central theme is understanding how the helical chirality and local architecture of DNA influence catalytic enantioselectivity, with applications in sustainable and selective synthesis of chiral compounds. The lab also explores functional DNA analogues for advanced sensing, including fluorescent probes for Z-DNA detection.
Professor Masumi Yamada's research lab specializes in observational seismology and landslide dynamics, focusing on the seismic signatures of large-scale geohazards such as landslides and volcanic tsunamis. The lab employs advanced seismic signal analysis, including broadband seismic recordings and back-projection techniques, to reconstruct the spatiotemporal evolution of slope failures and volcanic events. A key research direction involves understanding the dynamic friction and rupture processes in landslides through waveform analysis and precursory seismic sequences, contributing to improved hazard assessment and early warning systems. The lab also investigates atmospheric and oceanic coupling mechanisms in tsunami generation, particularly in explosive volcanic eruptions.
Professor Shingo Hiruma's research lab specializes in electromagnetic field analysis, with a focus on advanced numerical methods and modeling for electrical machines and magnetic materials. The lab develops innovative techniques in topology and parameter optimization, homogenization methods for complex materials like litz wires, and model order reduction for efficient simulation of electromagnetic systems. Key research directions include eddy current analysis, permeability characterization, and the application of integral equation methods to improve accuracy in finite element analysis. The lab's work bridges theoretical developments with practical applications in motor design and energy conversion systems.
Professor Hamid Hamidani's research lab specializes in high-energy astrophysics, focusing on the dynamics of relativistic jets in compact binary mergers and collapsars. The lab investigates jet propagation through complex, expanding media—particularly the ejecta from neutron star mergers—using advanced 2D and 3D relativistic hydrodynamic simulations combined with semi-analytical models. Key research directions include jet-cocoon interactions, breakout times, collimation, and multi-messenger emission signatures from short gamma-ray bursts and associated supernovae. The lab also explores the connection between jet engine properties and observable transients across electromagnetic bands.
Professor Tamao Maeda's research lab specializes in behavioral ecology and animal social systems, with a focus on understanding complex multilevel societies in free-ranging animals, particularly feral horses. The lab integrates cutting-edge drone technology with individual-level behavioral data to study social structure, association patterns, and behavioral synchrony in natural settings. A key emphasis is on applying non-invasive methods—such as drone-based aerial imaging, fecal analysis, and stable isotope techniques—to investigate the impacts of invasive species and artificial resources on animal behavior and ecosystem dynamics. The lab also develops multi-agent-based models to simulate and test hypotheses about social coordination and group-level functioning in complex societies.
Professor Masahide Takeda's research lab focuses on the molecular and cellular mechanisms underlying periodontal tissue homeostasis, inflammation, and regeneration. The lab investigates the roles of adenosine signaling via CD73 and adenosine receptors in immune cell trafficking, bone metabolism, and periodontal disease progression. A central theme is the impact of hypoxia and HIF-1α signaling on fibroblast and epithelial cell functions in the periodontium, particularly in collagen synthesis and inflammatory responses. The lab also pioneers translational approaches using autologous adipose-derived multi-lineage progenitor cells (ADMPCs) for regenerative therapy in periodontitis.
Professor Takeshi Seki's research lab specializes in spintronics and magnetic materials, focusing on the development and characterization of L1₀-FePt thin films with strong perpendicular magnetic anisotropy. The lab investigates current-induced magnetization switching, voltage control of magnetic properties, and spin Hall effects in nanostructured magnetic heterostructures, aiming to enable ultra-low-power magnetic memory and logic devices. Key research directions include spin-orbitronics, spin current generation, and energy-efficient dynamic voltage and frequency management in integrated circuits. The lab combines advanced thin-film growth, electrical transport measurements, and thermal imaging techniques to explore fundamental spin phenomena and their device applications.
Professor Yoji Horii's research lab specializes in the design, synthesis, and magnetic characterization of lanthanoid-based single-molecule magnets (SMMs), with a particular focus on phthalocyaninato-based multiple-decker complexes. The lab investigates how f-f interactions—despite their weak nature—can be harnessed to enhance SMM properties such as magnetic relaxation barriers and blocking temperatures. Key research directions include tuning magnetic anisotropy through molecular engineering, controlling supramolecular aggregation via ligand modification, and understanding the role of precise lanthanoid-lanthanoid distances and coordination geometries in SMM performance. The lab employs advanced techniques such as synchrotron X-ray crystallography, alternating current and direct current magnetic measurements, and UV/Vis-NIR and NMR spectroscopy to probe structure-property relationships at the molecular level.
Professor Shouhei Honda's research lab specializes in geometric analysis and metric measure geometry, focusing on the structure and convergence of Riemannian and RCD spaces under Gromov–Hausdorff topology. The lab investigates the behavior of differential structures, Laplacians, and p-Laplacians on limit spaces arising from sequences of manifolds with Ricci curvature bounds, particularly in noncollapsed settings. Key directions include L^p-convergence of tensor fields, spectral stability, and the application of heat kernel embeddings and geometric flows to understand curvature and measure-theoretic properties of singular spaces.
Professor Yuji Saito's research lab specializes in molecular and cellular biology, with a focus on signal transduction pathways involving receptor tyrosine kinases such as EGFR and PDGFR. The lab investigates cross-talk mechanisms between growth factor receptors and their roles in cell migration and proliferation, particularly in vascular smooth muscle cells. Additionally, the lab explores metabolic engineering of polyhydroxyalkanoates (PHAs) in bacteria, aiming to develop sustainable biopolymers with tunable physical and thermal properties. The integration of molecular signaling with synthetic biology and materials science defines the lab’s interdisciplinary approach.
Professor Yuichi Riku's research lab specializes in the neuropathology of neurodegenerative diseases, with a focus on the molecular and cellular mechanisms underlying TDP-43 and tau proteinopathies. The lab investigates the pathological continuum between frontotemporal lobar degeneration with TDP-43 pathology (FTLD-TDP), amyotrophic lateral sclerosis (ALS), and tauopathies such as progressive supranuclear palsy and corticobasal degeneration. A key research direction involves understanding the genetic and proteinopathological underpinnings of disorders like hereditary diffuse leukoencephalopathy with spheroids (HDLS), particularly through the identification of CSF1R mutations and their pathological consequences. The lab also explores the clinical significance of comorbid proteinopathies, emphasizing that co-occurring TDP-43 and tau pathologies are not incidental but contribute meaningfully to disease progression and phenotypic expression.
Professor Mariko Kawamura's research lab focuses on translational oncology and neurodegenerative disease mechanisms, with a strong emphasis on improving diagnostic and therapeutic strategies for breast cancer and central nervous system disorders. The lab investigates advanced imaging techniques, such as MRI, to predict treatment response in breast cancer patients and optimize radiotherapy delivery through innovations like intraoperative radiation therapy (IORT) and immobilization techniques. Additionally, the lab explores systemic links between chronic infections—such as *Helicobacter pylori*—and neurodegenerative or cardiovascular diseases, highlighting the role of glymphatic system dysfunction in neurodegeneration. The research integrates clinical imaging, molecular mechanisms, and patient outcomes to advance precision medicine in oncology and neuroscience.
