Tohoku University · Engineering
Professor Daotong Li's research lab focuses on the intricate relationships between diet, gut microbiota, and human health, with a particular emphasis on bioactive compounds such as anthocyanins and dietary fiber. The lab investigates the molecular mechanisms underlying the health benefits of these compounds, including their roles in regulating inflammation, metabolism, and intestinal homeostasis through microbial metabolites like inosine. Research also explores how dietary patterns and macronutrients influence cardiovascular disease risk and the detoxification pathways of dietary toxins such as acrylamide. The lab integrates nutritional science, microbiology, and molecular biology to identify novel therapeutic targets and functional food applications.
Figures are computed from collected data and may differ slightly.
Anthocyanins are one of the most widespread families of natural pigments in the plant kingdom. Their health beneficial effects have been documented in many in vivo and in vitro studies. This review summarizes the most recent literature regarding the health benefits of anthocyanins and their molecular mechanisms. It appears that several signaling pathways, including mitogen-activated protein kinase, nuclear factor κB, AMP-activated protein kinase, and Wnt/β-catenin, as well as some crucial cellul
Overall, our findings suggest that the gut microbiota-inosine-A<sub>2A</sub>R/PPARγ axis plays an important role in the maintenance of intestinal homeostasis, which may represent a novel approach for colitis prevention via manipulation of the gut microbial purine metabolite. Video Abstract.
The gut microbiota is a complex ecosystem consisted of trillions of microbes that have co-evolved with their host for hundreds of millions of years. During the last decade, a growing body of knowledge has suggested that there is a compelling set of connections among diet, gut microbiota and human health. Various physiological functions of the host, ranging from metabolic and immune regulation to nerve and endocrine development, are possibly mediated by the structural components of microbial cell
Cardiovascular disease (CVD) remains the first cause of mortality globally. Diet plays a fundamental role in cardiovascular health and is closely linked to the development of CVD. Numerous human studies have provided evidence on the relationship between diet and CVD. By discussing the available findings on the dietary components that potentially influence CVD progression and prevention, this review attempted to provide the current state of evidence on healthy dietary choices for CVD. We focus on
The genotoxic risk from AA may be determined by the balance between the phase I P450 2E1 (CYP2E1)-dependent toxification pathway to form genotoxic GA and the phase II GSH-conjugated detoxification pathway to form MA metabolite. Understanding the metabolism of AA in the body is helpful for developing effective intervention strategies to mitigate its toxicity.
Insoluble dietary fiber (IDF) is a nutritional component constituting the building block of plant cell walls. Our understanding of the role of IDF in plant-based foods has advanced dramatically in recent years. In this Review, we summarize research progress on the subtypes, structure, analysis, and extraction methods of IDF. The impact of different food processing methods on the properties of IDF is discussed. The role of gut microbiota in the health benefits of IDF is introduced. This review pr
This article presents a design strategy of dual-/tri-/quad-band substrate-integrated waveguide (SIW) bandpass filters (BPFs) based on a single perturbed multimode SIW cavity. By loading metallized vias or slotlines perturbed structures at the center of the proposed SIW cavity, the first four independent adjustable resonant modes of TE101, TE201, TE102, and TE202 modes are achieved. The resonant characteristics of the first four resonant modes are first investigated theoretically and numerically
A multichannel radiometer frontend, which can improve the radiometer sensitivity and utilization of the frequency band dramatically, is proposed based on the principle of bandwidth synthetic technology. The multichannel radiometer, called multichannel bandwidth synthetic radiometer (MCBWSR), consists of multiple conventional radiometer channels, and the frequency bands of all the channels are synthesized by the bandwidth synthesizer before the detector. The synthesized bandwidth of the synthesiz
A compact planar printed wideband filtering quasi-Yagi antenna without any extra external filtering circuit for vehicular communication is proposed in this article. It consists of a microstrip-to-slotline transition (MST), a coplanar stripline (CPS), driven elements and parasitic elements which act as directors and filtering elements simultaneously. The MST can inherently introduce four radiation nulls on the lower and upper stopband, and by adding a pair of exponential curved branch elements sy
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