Seoul National University · Medicine
Dong Ki Kim 교수의 연구실은 임상의학, 신경과학, 생물정보학 및 응용공학을 융합한 다학제적 연구를 중심으로 진행되고 있습니다. 특히 만성 병변에서의 전염병 및 면역 반응의 유전적 기반, 신장 및 뇌의 수액 균형 조절 메커니즘, 그리고 신경질환 환자에서의 전해질 이상에 대한 기전과 치료 전략을 중심으로 연구를 수행하고 있습니다. 또한, 인공지능 기반 자율주행 기술과 의료영상 기반 자세 추정 기술을 활용한 의료기기 및 진단 기술의 개발에도 기여하고 있습니다.
Figures are computed from collected data and may differ slightly.
The incidence of peritonitis for 2001 decreased to less than half that for 1992, due mainly to a significant decrease in CoNS-induced peritonitis, whereas the proportions of peritonitis due to a single gram-negative organism and methicillin-resistant CoNS increased. These findings suggest that it is necessary to prepare new center-based guidelines for the initial empirical treatment of CAPD peritonitis.
Autonomous indoor navigation of Micro Aerial Vehicles (MAVs) possesses many challenges. One main reason is that GPS has limited precision in indoor environments. The additional fact that MAVs are not able to carry heavy weight or power consuming sensors, such as range finders, makes indoor autonomous navigation a challenging task. In this paper, we propose a practical system in which a quadcopter autonomously navigates indoors and finds a specific target, i.e., a book bag, by using a single came
Abstract The EM algorithm is one of the most powerful algorithms for obtaining maximum likelihood estimates for many incomplete-data problems. But when the parameters must satisfy a set of linear restrictions, the EM algorithm may be too complicated to apply directly. In this article we propose maximum likelihood estimation procedures under a set of linear restrictions for situations in which the EM algorithm could be used if there were no such restrictions on the parameters. We develop a modifi
We propose a vision-based method that localizes a ground vehicle using publicly available satellite imagery as the only prior knowledge of the environment. Our approach takes as input a sequence of ground-level images acquired by the vehicle as it navigates, and outputs an estimate of the vehicle's pose relative to a georeferenced satellite image. We overcome the significant viewpoint and appearance variations between the images through a neural multi-view model that learns location-discriminati
To investigate the influence of genetic differences in the MHC on susceptibility to avian coccidiosis, M5.1 and M15.2 B-haplotype-disparate Fayoumi chickens were orally infected with live Eimeria maxima oocysts, and BW gain, fecal oocyst production, and expression of 14 immune-related genes were determined as parameters of protective immunity. Weight loss was reduced and fecal parasite numbers were lower in birds of the M5.1 line compared with M15.2 line birds. Intestinal intraepithelial lymphoc
Gonadotropin-releasing hormone-I (GnRH-I) is known to directly regulate prostate cancer cell proliferation. However, the role of GnRH-II in prostate cancer is unclear. Here, we investigated the effect of the GnRH-II antagonist trptorelix-1 (Trp-1) on growth of PC3 prostate cancer cells. Trp-1 induced growth inhibition of PC3 cells in vitro and inhibited growth of PC3 cells xenografted into nude mice. FITC-N3, an FITC-conjugated Trp-1 analogue, was largely present in the mitochondria of prostate
The kidney and the brain play a major role in maintaining normal homeostasis of the extracellular fluid by neuroendocrine regulation of sodium and water balance. Therefore, disturbances of sodium balance are common in patients with central nervous system (CNS) disorders and clinicians should focus not only on the CNS lesion, but also on the potentially deleterious complications. Hyponatremia is the most common and important electrolyte disorder affecting patients with critical neurologic disease
IL6 might play a prominent role in the local activation of JAK2/STAT3 in podocyte hypertrophy under HG conditions. <i>In vivo</i> studies examining this pathway are warranted.
The mCCI-IHD facilitates better risk stratification for mortality in incident hemodialysis patients compared with the CCI, suggesting that it may be a preferred index for use in clinical practice and the statistical analysis of epidemiological studies.
The rates of infection of two methods of external ventricular drainage in use at Atkinson Morley's Hospital--namely, (a) percutaneous drainage with Rickham reservoirs and (b) tunnelled ventriculostomies--were compared in this retrospective review. Percutaneous drainage of CSF with Rickham reservoirs was associated with a 27% rate of infection as identified by positive microbiological cultures; tunnelled ventriculostomy catheters had a 10% infection rate. The difference in the infection rate betw
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