Korea University · Engineering
Professor Dong-Kwon Lim's research lab specializes in the development and application of plasmonic nanomaterials, particularly gold nanoparticles, for advanced biomedical diagnostics and therapeutics. The lab focuses on leveraging the photothermal and surface-enhanced Raman scattering (SERS) properties of these nanomaterials to enable rapid, sensitive, and label-free detection of pathogens and biomolecules. Key research directions include the design of nanosensors for early sepsis diagnosis, integration of nanomaterials with techniques like photoacoustic imaging and PCR, and the use of SERS for molecular-level analysis of nucleic acids and cellular components. The lab aims to bridge nanotechnology with clinical needs to create point-of-care solutions for infectious diseases and cancer.
Figures are computed from collected data and may differ slightly.
Gold nanoparticles (AuNPs) have received great attention for various medical applications due to their unique physicochemical properties. AuNPs with tunable optical properties in the visible and near-infrared regions have been utilized in a variety of applications such as in vitro diagnostics, in vivo imaging, and therapeutics. Among the applications, this review will pay more attention to recent developments in diagnostic and therapeutic applications based on the photothermal (PT) effect of AuN
Sepsis is a critical disease caused by the abrupt increase of bacteria in human blood, which subsequently causes a cytokine storm. Early identification of bacteria is critical to treating a patient with proper antibiotics to avoid sepsis. However, conventional culture-based identification takes a long time. Polymerase chain reaction (PCR) is not so successful because of the complexity and similarity in the genome sequence of some bacterial species, making it difficult to design primers and thus
SERS have been attracted as a bioanalytical tool by utilizing plasmonic nanomaterials to enhance the intensity of Raman scattering. Two different analytes such as nucleic acid target or natural biomolecules inside single cell have been investigated in our research group. For nucleic acid target, it is inevitable for the use of surrogate to determine the presence of specific nucleic acid target. Our recent study showed that SERS is superior to assay performance of fluorescence-based assay (Sensor
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