Sungkyunkwan University · Medicine
Dong-Gyu Jo 교수의 연구실은 신경퇴행성 질환, 특히 알츠하이머병에서의 단백질 수영성 변화와 세포 사멸 경로 간의 상관관계를 중심으로 연구를 진행하고 있습니다. 특히 O-GlcNAc 수영성의 변화가 아밀로이드 베타 축적과 난소세포사(necroptosis)에 미치는 영향을 규명하며, 뇌질환 치료의 새로운 타겟을 모색하고 있습니다. 또한 류머티스 관절염과 같은 염증성 질환에 대비한 표적 치료제 개발을 위해 히알루론산 기반 약물 접합체를 활용한 pH 민감성 약물 방출 시스템도 개발하고 있습니다.
Figures are computed from collected data and may differ slightly.
<i>O</i>-GlcNAcylation (<i>O</i>-linked β-<i>N</i>-acetylglucosaminylation) is notably decreased in Alzheimer's disease (AD) brain. Necroptosis is activated in AD brain and is positively correlated with neuroinflammation and tau pathology. However, the links among altered <i>O</i>-GlcNAcylation, β-amyloid (Aβ) accumulation, and necroptosis are unclear. Here, we found that <i>O</i>-GlcNAcylation plays a protective role in AD by inhibiting necroptosis. Necroptosis was increased in AD patients and
In an effort to improve the therapeutic efficacy of methotrexate (MTX), we prepared the hyaluronic acid-MTX conjugate for targeted therapy of rheumatoid arthritis (RA). Owing to the pH-sensitive nature of the conjugate, MTX was rapidly released under the mildly acidic conditions, similar to the environment of inflamed synovial tissue in RA.
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