Sungkyunkwan University · Medicine
Professor Dongryeol Ryu's research lab focuses on the molecular and cellular mechanisms underlying muscle degeneration, mitochondrial dysfunction, and metabolic diseases, with an emphasis on identifying key regulators such as NAD+ and GDF15 in maintaining muscle and metabolic health. The lab investigates tissue engineering strategies—particularly cell-laden hydrogel constructs—for treating volumetric muscle loss, integrating biomaterials and regenerative medicine approaches. Additionally, the lab explores the role of endoplasmic reticulum stress and altered cancer metabolism in chemoresistance, particularly in gastric cancer, aiming to develop metabolic interventions to overcome therapeutic resistance. Their work bridges systems biology, regenerative medicine, and translational therapeutics to address age-related and disease-associated tissue dysfunction.
Figures are computed from collected data and may differ slightly.
Neuromuscular diseases are often caused by inherited mutations that lead to progressive skeletal muscle weakness and degeneration. In diverse populations of normal healthy mice, we observed correlations between the abundance of mRNA transcripts related to mitochondrial biogenesis, the dystrophin-sarcoglycan complex, and nicotinamide adenine dinucleotide (NAD<sup>+</sup>) synthesis, consistent with a potential role for the essential cofactor NAD<sup>+</sup> in protecting muscle from metabolic and
Mitochondrial dysfunction is associated with aging-mediated inflammatory responses, leading to metabolic deterioration, development of insulin resistance, and type 2 diabetes. Growth differentiation factor 15 (GDF15) is an important mitokine generated in response to mitochondrial stress and dysfunction; however, the implications of GDF15 to the aging process are poorly understood in mammals. In this study, we identified a link between mitochondrial stress-induced GDF15 production and protection
Volumetric muscle loss (VML) is associated with a severe loss of muscle tissue that overwhelms the regenerative potential of skeletal muscles. Tissue engineering has shown promise for the treatment of VML injuries, as evidenced by various preclinical trials. The present study describes the fabrication of a cell-laden GelMa muscle construct using an <i>in situ</i> crosslinking (ISC) strategy to improve muscle functionality. To obtain optimal biophysical properties of the muscle construct, two UV
These results demonstrate that ER stress-induced LIPIN2 would contribute to the perturbation of hepatic insulin signaling via a DAG-protein kinase C ε-dependent manner in DIO mice.
Resistance to anticancer therapeutics occurs in virtually every type of cancer and becomes a major difficulty in cancer treatment. Although 5-fluorouracil (5FU) is the first-line choice of anticancer therapy for gastric cancer, its effectiveness is limited owing to drug resistance. Recently, altered cancer metabolism, including the Warburg effect, a preference for glycolysis rather than oxidative phosphorylation for energy production, has been accepted as a pivotal mechanism regulating resistanc
Open papers in the app to read, cite, and organize with AI.
