Tokyo Institute of Technology · Computer Science
Professor Dongyuan Li's research lab specializes in computational biology, network science, and machine learning with a focus on understanding complex biological systems through advanced data-driven methods. The lab develops innovative algorithms for dynamic network analysis—particularly in cancer progression—integrating temporal data and multi-omics information to uncover evolving biological modules. They also pioneer graph-based deep learning techniques for multimodal data fusion, especially in emotion recognition and drug discovery. Their work bridges computational methodology with translational biomedical applications, including cancer therapy and dye design for solar energy conversion.
Figures are computed from collected data and may differ slightly.
Active learning seeks to achieve strong performance with fewer training samples. It does this by iteratively asking an oracle to label newly selected samples in a human-in-the-loop manner. This technique has gained increasing popularity due to its broad applicability, yet its survey papers, especially for deep active learning (DAL), remain scarce. Therefore, we conduct an advanced and comprehensive survey on DAL. We first introduce reviewed paper collection and filtering. Second, we formally def
Tracking the dynamic modules (modules change over time) during cancer progression is essential for studying cancer pathogenesis, diagnosis, and therapy. However, current algorithms only focus on detecting dynamic modules from temporal cancer networks without integrating the heterogeneous genomic data, thereby resulting in undesirable performance. To attack this issue, we propose a novel algorithm (aka TANMF) to detect dynamic modules in cancer temporal attributed networks, which integrates the t
Multimodal emotion recognition aims to recognize emotions for each utterance from multiple modalities, which has received increasing attention for its application in human-machine interaction. Current graph-based methods fail to simultaneously depict global contextual features and local diverse uni-modal features in a dialogue. Furthermore, with the number of graph layers increasing, they easily fall into over-smoothing. In this paper, we propose a method for joint modality fusion and graph cont
Temporal networks are ubiquitous in nature and society, and tracking the dynamics of networks is fundamental for investigating the mechanisms of systems. Dynamic communities in temporal networks simultaneously reflect the topology of the current snapshot (clustering accuracy) and historical ones (clustering drift). Current algorithms are criticized for their inability to characterize the dynamics of networks at the vertex level, independence of feature extraction and clustering, and high time co
These results suggest that miR-1225-5p may be a novel candidate for glioblastoma therapy.
The performance of two donor-π-bridge-acceptor type phenothiazine dyes bearing different π-bridges (furan and thiophene) was investigated by density functional theory and time-dependent density functional theory to explore the reasons for the differences in DSSC efficiency. It was revealed that dye1 with furan showed higher short-circuit photocurrent density due to its larger driving force and better light harvesting efficiency compared with dye2. Moreover, a larger number of photo-injected elec
With the booming development of social media, temporal link prediction (TLP), as a core technology, has been receiving increasing attention. However, current methods are based on graph neural networks, which suffer from the over-smoothing issue and easily yield indistinguishable node representations, degrading the prediction accuracy. Besides, they lack the ability to eliminate noisy temporal information and ignore the importance of high-order neighbor information for measuring the link probabil
Large multi-flexible-body space structures, such as space solar arrays, comprise of multiple flexible substructures that are connected by joint hinges. Unlike traditional continuous structural models, a noncontinuous multi-flexible-body structural model with joint hinges is set up for the multi-flexible-body structure herein. In contrast to the general multi-body structural models in which each substructure is taken as a rigid body, the elastic deformation of every substructure in the multi-flex
Multimodal emotion recognition aims to recognize emotions for each utterance of multiple modalities, which has received increasing attention for its application in human-machine interaction. Current graph-based methods fail to simultaneously depict global contextual features and local diverse uni-modal features in a dialogue. Furthermore, with the number of graph layers increasing, they easily fall into over-smoothing. In this paper, we propose a method for joint modality fusion and graph contra
Speech emotion recognition (SER) has drawn increasing attention for its applications in human-machine interaction. However, existing SER methods ignore the information gap between the pre-training speech recognition task and the downstream SER task, leading to sub-optimal performance. Moreover, they require much time to fine-tune on each specific speech dataset, restricting their effectiveness in real-world scenes with large-scale noisy data. To address these issues, we propose an active learnin
Dynamic graph clustering aims to detect and track time-varying clusters in dynamic graphs, revealing the evolutionary mechanisms of complex real-world dynamic systems. Matrix factorization-based methods are promising approaches for this task; however, these methods often struggle with scalability and can be time-consuming when applied to large-scale dynamic graphs. Moreover, they tend to lack robustness and are vulnerable to real-world noisy data. To address these issues, we make three key contr
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