The University of Osaka · Biochemistry, Genetics and Molecular Biology
Professor Eiichiro Fukusaki's research lab specializes in metabolomics and systems biology, focusing on the application of advanced analytical technologies—particularly GC-MS—for understanding metabolic responses in toxicology and pharmacology. The lab investigates the mechanisms of drug-induced toxicity, such as hydrazine-induced hepatotoxicity, by profiling endogenous metabolites in biological fluids and tissues. Their work bridges metabolomics with systems-level analysis to uncover metabolic pathways involved in disease and drug response. The lab also contributes to the development of non-invasive biomarkers for early detection of toxicity and disease.
Figures are computed from collected data and may differ slightly.
Gas chromatography-mass spectrometry (GC-MS) has great advantages for analyzing organic/amino acids, which are often targets in efficacy and/or toxicity studies. Although GC-MS has been used for the detection of many metabolic disorders, applications of GC-MS-based metabolomics in pharmacology/toxicology are relatively underdeveloped. We intended to investigate applicability of a GC-MS-based metabolomics approach for toxicological evaluation, and tried to elucidate the mechanism of hydrazine-ind
Open papers in the app to read, cite, and organize with AI.
