Seoul National University · Medicine
Professor Eun Young Lee's research lab specializes in the design and synthesis of functional metal-organic frameworks (MOFs) with tailored porosity, stability, and stimuli-responsive properties. The lab focuses on creating porous coordination materials that exhibit high surface areas, permanent microporosity, and exceptional thermal and structural stability—enabling applications in gas storage, selective guest binding, and luminescent sensing. In parallel, the lab investigates the role of extracellular vesicles, particularly exosomes, in inflammatory joint diseases such as rheumatoid arthritis, with an emphasis on their influence on osteoclast differentiation and bone destruction. These interdisciplinary efforts bridge materials science and biomedical research, aiming to develop advanced functional materials and uncover disease mechanisms in autoimmune arthritis.
Figures are computed from collected data and may differ slightly.
A porous metal-organic framework [Zn(4)O(NTB)(2)].3DEF.EtOH (1), in which (3,6)-connected nets are doubly interpenetrated to generate curved three-dimensional channels, has been prepared. Framework 1 exhibits high permanent porosity (Langmuir surface area, 1121 m(2)/g; pore volume, 0.51 cm(3)/cm(3)), high thermal stability (up to 430 degrees C), high hydrogen adsorption capacity (1.9 wt % at 77 K and 1 atm), selective organic guest binding ability (K(f)()( )(): MeOH > pyridine > benzene > dodeca
Hole in one: A metal–organic framework with permanent microporosity has been constructed from linear coordination polymer chains consisting of [Ni(cyclam)]2+ and bpydc2−. In framework 1 the chains run in three directions (red, green, blue in the picture) and are stacked to form 1D channels that are filled with water molecules, which can be removed completely and reabsorbed with retention of the single crystallinity.
Löchrige Sache: Eine metallo-organische Architektur mit stabilen Mikroporen wurde aus eindimensionalen Koordinationspolymeren, bestehend aus [Ni(cyclam)]2+-Einheiten und bpydc2−-Liganden, aufgebaut. Im Netzwerk 1 sind in drei Richtungen verlaufende Ketten (rot, grün und blau, siehe Bild) zu Kanälen gestapelt. Wassermoleküle, die in diesen Kanälen adsorbiert sind, können unter Aufrechterhaltung der Einkristallinität entfernt und readsobiert werden.
This study aimed to investigate the characteristics of exosomes isolated from synovial fluid and their role in osteoclast differentiation in different types of inflammatory arthritis. Exosomes isolated from synovial fluid of rheumatoid arthritis (RA), ankylosing spondylitis (AS), gout, and osteoarthritis (OA) patients were co-incubated with CD14+ mononuclear cells from healthy donors without macrophage colony-stimulating factor (M-CSF) and receptor activator of nuclear factor kappa-B ligand (RAN
Most patients with RA-ILD experienced stable or slowly declining lung function. In 5% of patients, predicted FVC% deteriorated rapidly, especially in older adults with early RA. The lung function trajectory was not comparable to the RA disease activity trajectory.
Immune complexes containing citrullinated fibrinogen are present in the sera and synovium of rheumatoid arthritis patients and potentially contribute to synovitis. However, fibrinogen can inhibit the osteoclastogenesis of precursor cells. We investigated the direct effect of citrullinated fibrinogen on osteoclastogenesis to understand the role of citrullination on bone erosion of rheumatoid arthritis patients. We evaluated the fibrinogen citrullination sites using mass spectrometry and quantifie
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