Keio University · Neuroscience
Professor Fuminari Kaneko's research lab specializes in neuromodulation and motor recovery, focusing on the neural mechanisms underlying kinesthetic illusions, cortical excitability, and neuroplasticity in neurological rehabilitation. The lab investigates how visual and sensory feedback can induce illusory motor sensations and enhance motor function in patients with chronic stroke or muscle atrophy following ACL reconstruction. Key research directions include the integration of functional electrical stimulation, motor imagery, transcranial direct current stimulation (tDCS), and visual feedback to modulate corticospinal excitability and reorganize resting-state brain networks. The lab also explores the role of central motor commands and peripheral afferent input in driving cortical plasticity for improved motor outcomes.
Figures are computed from collected data and may differ slightly.
It is well known that kinesthetic illusions can be induced by stimulation of several sensory systems (proprioception, touch, vision…). In this study we investigated the cerebral network underlying a kinesthetic illusion induced by visual stimulation by using functional magnetic resonance imaging (fMRI) in humans. Participants were instructed to keep their hand still while watching the video of their own moving hand (Self Hand) or that of someone else's moving hand (Other Hand). In the Self Hand
Prolonged electromechanical delay in twitch response may be due to peripheral physiological disruptions (eg, stiffness of the series elastic component, changes of peripheral muscle fiber-type composition, or a decrease in function of the excitation-contraction coupling process). A prolonged electromechanical delay in twitch response can also explain the prolonged electromechanical delay observed for MVC. These findings suggest that prolonged total reaction time in MVC, when secondary to a visual
The combination of voluntary effort and functional electrical stimulation (ES) appears to have a greater potential to induce plasticity in the motor cortex than either electrical stimulation or voluntary training alone. However, it is not clear whether the motor commands from the central nervous system, the afferent input from peripheral organs, or both, are indispensable to induce the facilitative effects on cortical excitability. To clarify whether voluntary motor commands enhance corticospina
Barring a few studies, there are not enough established treatments to improve upper limb motor function in patients with severe impairments due to chronic stroke. This study aimed to clarify the effect of the kinesthetic perceptional illusion induced by visual stimulation (KINVIS) on upper limb motor function and the relationship between motor function and resting-state brain networks. Eleven patients with severe paralysis of upper limb motor function in the chronic phase (seven men and four wom
A kinesthetic illusion induces a feeling as if an individual’s own body is moving during sensory input, even though the body is actually in a resting state. In a previous study, we reported that a visually induced kinesthetic illusion (KiNVIS) increases corticospinal tract excitability that is associated with activity of the motor-association regions. The present study explored the acute effect of KiNVIS on motor function in five patients who had experienced stroke, as a preliminary study. Five
Our results suggest that tDCSa + KIMI has a greater therapeutic potential than tDCS alone for inducing higher excitability of the corticospinal tract. The observed effects may be related to sustained potentiation of resultant cerebral activity during combined KI, MI, and tDCSa.
This meta-analysis demonstrated that RAGT therapy in combination with NIBS was effective in patients with stroke and SCI. However, a greater improvement in lower limb function and activities were not observed using RAGT with tDCS compared to sham stimulation.
In patients with chronic stroke who were unable to extend their paretic fingers for a prolonged period of time, the application of KINVIS, which evokes kinesthetic perception, improved their ability to induce motor imagery. Our findings suggest that although KINVIS is a passive intervention, its short-term application can induce changes related to the motor output system.
<b>Aims:</b> Therapy with kinesthetic illusion of segmental body part induced by visual stimulation (KINVIS) may allow the treatment of severe upper limb motor deficits in post-stroke patients. Herein, we investigated: (1) whether the effects of KINVIS therapy with therapeutic exercise (TherEx) on motor functions were induced through improved spasticity, (2) the relationship between resting-state functional connectivity (rs-FC) and motor functions before therapy, and (3) the baseline characteris
The authors investigated whether working memory training improves motor-motor dual-task performance consisted of upper and lower limb tasks. The upper limb task was a simple reaction task and the lower limb task was an isometric knee extension task. 45 participants (age = 21.8 ± 1.6 years) were classified into a working memory training group (WM-TRG), dual-task training group, or control group. The training duration was 2 weeks (15 min, 4 times/week). Our results indicated that working memory ca
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