Sungkyunkwan University · Medicine
Professor Gee Young Suh's research lab specializes in molecular and cellular mechanisms underlying inflammatory responses, with a particular focus on the regulation of cyclooxygenase-2 (COX-2) and the anti-inflammatory effects of carbon monoxide (CO). The lab investigates how endogenous and exogenous CO modulate immune cell signaling, especially in macrophages, using in vitro models such as RAW 264.7 cells. Key research directions include the signaling pathways involved in LPS-induced COX-2 expression and the role of heme oxygenase-1 (HO-1) in mediating protective responses against inflammation. The lab also explores the therapeutic potential of CO-releasing molecules in inflammatory diseases.
Figures are computed from collected data and may differ slightly.
Cyclooxygenase-2 (COX-2) is a key enzyme involved in the inflammatory process that is rapidly induced in macrophages in response to LPS. Carbon monoxide (CO), a byproduct of heme oxygnease-1, can suppress proinflammatory response in various in vitro and in vivo models of inflammation. This study was undertaken to examine whether CO can regulate (and if so, to delineate the mechanism by which CO regulates) LPS-induced COX-2 expression in macrophages. RAW 264.7 murine macrophages were stimulated w
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