Kyushu University · Medicine
Professor Goro Motomura's research lab specializes in orthopedic biomechanics and osteonecrosis of the femoral head (ONFH), focusing on the pathological mechanisms underlying femoral head collapse and the biomechanical stress distribution in early-stage disease. The lab employs advanced imaging techniques, patient-specific finite element modeling, and histological analysis to investigate how necrotic bone lesions progress to structural failure. A key research direction involves evaluating the protective effects of combined medical therapies—such as anticoagulants and lipid-lowering agents—against steroid-induced osteonecrosis in preclinical models. The lab also explores the role of sclerotic boundaries and trabecular architecture in disease progression using micro-CT and surgical specimen analysis.
Figures are computed from collected data and may differ slightly.
This study experimentally confirmed that the combined use of an anticoagulant and a lipid-lowering agent helps prevent steroid-induced ON in rabbits.
In order to investigate the mechanisms of collapse in osteonecrosis of the femoral head, we examined which part of the femoral head was the key point of a collapse and whether a collapsed region was associated with the size of the necrotic lesion. Using 30 consecutive surgically removed femoral heads we retrospectively analysed whole serial cut sections, specimen photographs, specimen radiographs and histological sections. In all of the femoral heads, collapse consistently involved a fracture at
Stress distribution remains unclear in early-stage osteonecrosis of the femoral head (ONFH). To clarify this issue, we generated patient-specific finite element models (FEMs) from 51 patients with ONFH. Patients' hips were classified into three groups: ONFH without a sclerotic boundary (Stage 1, n = 6), ONFH with a sclerotic boundary (Stage 2, n = 10), and ONFH with both a sclerotic boundary and <2 mm collapse (Stage 3, n = 35). Four hips without ONFH were used as controls. Stress distribution i
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