Nagoya University · Medicine
Professor Hidemi Ito's research lab specializes in molecular epidemiology and cancer genetics, focusing on the role of DNA repair genes in carcinogenesis. The lab investigates genetic polymorphisms in key DNA repair proteins such as APE1 and XRCC1, and their interactions with environmental factors like smoking in modulating lung cancer risk. Using population-based case-control studies and molecular epidemiological approaches, the lab aims to identify genetic susceptibility markers for cancer. Their work contributes to personalized cancer risk assessment and prevention strategies.
Figures are computed from collected data and may differ slightly.
APE1 (apurinic/apyrimidinic endonuclease 1) and XRCC1 (X-ray cross-complementing group 1) are DNA repair proteins that play important roles in the base excision repair (BER) pathway. Polymorphisms in their encoding genes are associated with altered DNA repair capacity and thus may impact on cancer risk. In the present case-control study with 178 Japanese incident lung cancer cases and 449 age- and sex-matched controls, we investigated the gene-environment interaction among APE1 Asp148Glu, XRCC1
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