Keio University · Engineering
Professor Hidetoshi Takahashi's research lab specializes in micro- and nano-scale sensor development, particularly focusing on piezoresistive sensors for biomedical and biological applications. The lab investigates innovative microfabrication techniques for creating high-sensitivity pressure sensors and force measurement systems, including micro force plate arrays for insect locomotion studies. Additionally, the lab explores biomedical applications of novel compounds, such as antibiotics isolated from actinomycetes, and contributes to surgical robotics through force feedback systems for minimally invasive surgery. The research integrates microsystems engineering with neuroscience and biomedicine to address challenges in human health and physiological measurement.
Figures are computed from collected data and may differ slightly.
This paper reports on a differential pressure sensor using a piezoresistive cantilever with the dimensions of 125 µm×100 µm×0.3 µm. The sensor has a higher sensitivity than a traditional diaphragm sensor because of the three free edges of the cantilever. The measured results indicated that the fabricated cantilever bent according to theory when differential pressure was applied. The sensitivity and resolution of the differential pressure were 3.2×10−4 Pa−1 and 0.02 Pa from −20 Pa to 20 Pa, respe
New antibiotics named reveromycins A, B, C and D were isolated as inhibitors of mitogenic activity induced by epidermal growth factor (EGF) in a mouse epidermal keratinocyte. Reveromycins were produced by a soil actinomycete (strain SN-593) which belongs to the genus Streptomyces.
A terrestrial insect can perform agile running maneuvers. However, the balance of ground reaction forces (GRFs) between each leg in an insect have remained poorly characterized. In this report, we present a micro force plate array for the simultaneous measurement of the anterior and vertical components of GRFs of multiple legs during the running motion of an ant. The proposed force plate, which consists of a 2000 µm × 980 µm × 20 µm plate base as the contact surface of an ant's leg, and the supp
This paper describes a theoretical estimation of the geometry of negative epoxy-resist microneedles prepared via inclined/rotated ultraviolet (UV) lithography based on spatially controlled UV exposure doses. In comparison with other methods based on UV lithography, the present method can create microneedle structures with high scalability. When negative photoresist is exposed to inclined/rotated UV through circular mask patterns, a three-dimensional, needle-shaped distribution of the exposure do
For a laparoscopic surgery, master-slave type surgery assisting systems have been developed. It is expected that introducing force feedback for the master-slave system improves the operability. However, measurement of grasping or reacting force for the forceps is difficult, in particular, in case of a bending type forceps. Therefore, in the paper, a method to calculate the force applying on the tip of the forceps is proposed by measuring a force applying on the driving shafts of a link-type two
Both spatial working memory deficit and disorganization symptoms have been considered significant components of schizophrenic impairment involved with the dorsolateral prefrontal cortex. The purpose of the present study was to investigate the relationships among spatial working memory, psychiatric symptoms including disorganization symptoms, and social functioning in schizophrenia. Fifty clinically stable patients with schizophrenia and 34 healthy controls participated in the study. Patients wer
This paper presents direct measurements of the aerodynamic forces on the wing of a free-flying, insect-like ornithopter that was modeled on a hawk moth (Manduca sexta). A micro differential pressure sensor was fabricated with micro electro mechanical systems (MEMS) technology and attached to the wing of the ornithopter. The sensor chip was less than 0.1% of the wing area. The mass of the sensor chip was 2.0 mg, which was less than 1% of the wing mass. Thus, the sensor was both small and light in
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