Kyoto University · Materials Science
Professor Hiroshi Sakaguchi's research lab specializes in the design, synthesis, and characterization of functional nanomaterials and molecular architectures with tailored electronic and optical properties. The lab focuses on bottom-up fabrication techniques such as radical-polymerized chemical vapor deposition and electrochemical polymerization to create graphene nanoribbons, conjugated copolymers, and self-assembled monolayers with precise control over structure and function. Key research directions include molecular-scale electrical conduction, second harmonic generation in organized molecular films, and the development of advanced materials for optoelectronic and biomedical applications.
Figures are computed from collected data and may differ slightly.
Radical-polymerized chemical vapor deposition, a new bottom-up method, was developed to produce graphene nanoribbons (GNRs) efficiently, despite the use of extremely low vacuum. Using this technique, a systematic synthesis of a multilayered high-density array of width-controlled sub-1 nm GNRs on a metal surface, with width-dependent band gap, is made possible. GNR films transferred onto insulating substrates behave as an excellent photoconductor.
Electrochemical polymerization of two different kinds of thiophene monomers on an iodine-covered gold surface created highly assembled conjugated copolymers with different electronic structures. A scanning tunneling microscope revealed images of several linkage types: diblock, triblock, and multiblock. The single strand of conjugated copolymers exhibited an anomalous swinging motion on the surface. This technique presents the possibility of understanding the copolymerization process from the dif
Performance of nonresonant tunnel conduction through a self-assembled monolayer of conjugated molecules fabricated on gold (111) was determined by virtue of nanometer-scale electrical probe measurement using a conductive atomic force microscope. Electrical measurements with nanometer spatial resolution enabled mapping of tunnel current as well as efficiency of tunnel conduction through molecular wire by analyzing length dependence on current. A series of conjugated molecules with different numbe
[reaction: see text] A stereocontrolled total synthesis of (-)-kainic acid is described. A fully functionalized trisubstituted pyrrolidine ring was constructed by ring-closing metathesis of an acrylate derivative followed by an intramolecular Michael addition of the resultant alpha,beta-unsaturated lactone with high diastereoselectivity. Two alternative protocols for the construction of the alpha,beta-unsaturated lactone were also developed.
Predicting the response to immunosuppressive therapy could provide useful information to help the clinician define treatment strategies for patients with aplastic anemia. In our current study, we evaluated the relationship between telomere length of lymphocytes at diagnosis and the response to immunosuppressive therapy in 64 children with aplastic anemia, using flow fluorescence in situ hybridization. Median age of patients was ten years (range 1.5-16.2 years). Severity of the disease was classi
Abstract An alternate Y type LB multilayer capable of SHG was prepared by the use of an amphiphilic ruthenium(II) tris(2,2′-bipyridine) complex. The large angular dependence of the second harmonic light intensity and the electronic absorption of the multilayer indicated that the SHG was due to MLCT transition of the ruthenium complex.
A total synthesis of (-)-kainic acid starting from the commercially available 2-azetidinone is described. The key delta-lactone intermediate was concisely prepared from the commercially available azetidinone through the Reformatsky-type reaction and an introduction of a glycine moiety. The construction of the functionalized pyrrolidine ring was executed by a one-pot sequential elimination-Michael addition protocol of a beta-amino-delta-lactone intermediate with high diastereoselectivity.
The cystic dilatation of the glomerular tuft due to the mesangiolysis was noted after the intravenous injection of the “Habu snake” venom (2mg per kg of body weight) into the rabbits. A total of 45 rabbits were used in this experiment and were sacrificed at selected intervals from a half to ten hours after the injections.The results obtained are as follows:1. The initial change of the mesangiolysis is the decreased density of the mesangial matrix and successively small canaliculi formation in th
ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTSubpicosecond photoinduced switching of second-harmonic generation from a ruthenium complex in supported Langmuir-Blodgett filmsHiroshi Sakaguchi, Luis A. Gomez-Jahn, Mark Prichard, Thomas L. Penner, David G. Whitten, and Toshihiko NagamuraCite this: J. Phys. Chem. 1993, 97, 8, 1474–1476Publication Date (Print):February 1, 1993Publication History Published online1 May 2002Published inissue 1 February 1993https://pubs.acs.org/doi/10.1021/j100110a002http
An electron microscopic study of the renal tubule cells of rabbit by part was performed.1. Because of the apparent structural differences between the ceels of proximal convolution and the comparatively straight medullary portion, we added the straight medullary portion to Maximow-Bloom's classification of the nephron.2. In all parts of the nephron except the papillary duct, basal intus-susceptions were observed either in a well differentiated or an undifferentiated form.3. Two types of capillari
Upon Nd-YAG laser irradiation of a Langmuir-Blodgett film containing Ru(II)-bipyridine metal complex, strong second-harmonic light at 532 nm is observed. The second-harmonic light intensity is remarkably suppressed when the ruthenium complex is excited by other laser pulses (either 355 nm or 460 nm) just before Nd-YAG laser irradiation at 1064 nm. This phenomenon is ascribed to the reduction in hyperpolarizability on going from the ground state to a metal-to-ligand charge-transferred excited sta
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