Kyoto University · Medicine
Professor Hiroyuki Fujimoto's research lab specializes in advanced materials science with a focus on high-temperature superconductors and energy storage materials. The lab investigates the mechanical and superconducting properties of rare-earth barium copper oxide (REBCO) materials, particularly through melt-processing techniques to enhance fracture toughness and critical current density for practical applications. In parallel, the lab conducts cutting-edge studies on lithium-ion battery materials, employing in situ and operando techniques such as synchrotron X-ray diffraction to unravel the structural evolution and reaction mechanisms in graphite anodes. The integration of materials characterization with functional performance analysis underpins the lab’s mission to develop reliable, high-performance materials for energy and biomedical applications.
Figures are computed from collected data and may differ slightly.
The fracture toughness of melt-powder-melt-growth(MPMG)-processed YBaCuO samples was measured and the beneficial effect of the dispersed 211 particles in the 123 superconducting phase on toughening the material was confirmed. Preferred fracture planes were (100), (010) and (001) planes, and the fracture toughness of the (001) plane was lower than that of the (100) and (010) planes.
Mechanical properties, such as flexural strength, fracture toughness and ductility, and superconducting properties, Tc, Jc and Hirr, are crucial for industrial applications of high-Tc oxide superconductors. However, oxide superconductors have the intrinsic brittleness of the perovskite structure, thus the strength and the fracture toughness of the materials are low and anisotropic. Therefore, it is very important to study and improve mechanical properties to achieve structural reliability for ap
Since the commercialization of rechargeable Li ion batteries in the early 1990 s, the performance of these devices has continually improved. In such batteries, graphite is typically used as the negative electrode and the present work examined the reaction mechanisms at graphite negative electrodes based on operando synchrotron X-ray diffraction analyses during charge/discharge. The resulting in-plane diffraction patterns of the Li-intercalated graphite permitted a detailed analysis of changes in
The emergence of small interfering RNA (siRNA) opened a new opportunity to study gene functions in a genome. However, large-scale loss-of-function analyses further require cell-based high-throughput methods that allow simultaneous silencing of the huge number of genes by siRNA. In this study, we aim at fabricating the cell-based siRNA arrays that facilitate parallel introduction of multiple siRNAs into cultured mammalian cells. The siRNA arrays were prepared using surface chemical processes incl
Pancreatic β-cell mass (BCM) has a central importance in the pathophysiology of diabetes mellitus. Recently, pancreatic β-cell-specific imaging, especially positron emission tomography (PET) with exendin-based probes, has emerged for non-invasive evaluation of BCM. We developed a novel exendin-based probe labeled with fluorine-18, [<sup>18</sup>F]FB(ePEG12)12-exendin-4 (<sup>18</sup>F-Ex4) for PET imaging. We subsequently conducted a first-in-human phase 1 study of <sup>18</sup>F-Ex4 PET/compute
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