Hiroyuki Suzuki

Complementary DNAs encoding rat long-chain acyl-CoA synthetase have been isolated. The cDNAs were identified using synthetic oligonucleotide probes based on partial amino acid sequences of lysyl endopeptidase peptides of the purified enzyme. Rat long-chain acyl-CoA synthetase is predicted to contain 699 amino acid residues and to have a calculated molecular weight of 78,177. Significant sequence similarity was found between parts of long-chain acyl-CoA synthetase and firefly luciferase. Based on

In chronic kidney disease (CKD), enhanced intrarenal angiotensin II (AngII) is involved in deterioration of renal function, but it is difficult to measure it. For assessment of the potential of urinary angiotensinogen as a marker of intrarenal AngII activity, the correlation of plasma and urinary renin-angiotensin system components, including angiotensinogen, with deterioration of renal function was investigated in 80 patients who had CKD and were not treated with AngII blocking agents. Changes

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTThe First Genuine Silicon-Sulfur Double-Bond Compound: Synthesis and Crystal Structure of a Kinetically Stabilized SilanethioneHiroyuki Suzuki, Norihiro Tokitoh, Shigeru Nagase, and Renji OkazakiCite this: J. Am. Chem. Soc. 1994, 116, 25, 11578–11579Publication Date (Print):December 1, 1994Publication History Published online1 May 2002Published inissue 1 December 1994https://pubs.acs.org/doi/10.1021/ja00104a052https://doi.org/10.1021/ja00104a052researc

Diaryltetrathiasilolanes 2a,b, bearing bulky aryl groups such as 2,4,6-tris[bis(trimethylsilyl)methyl]phenyl (Tbt), mesityl (Mes), and 2,4,6-triisopropylphenyl (Tip), were obtained by thermal reaction of dihydrosilane 3a with elemental sulfur, reaction of highly hindered disilene 4 with sulfur, or reduction of dibromosilane 6 followed by addition of sulfur. The molecular structure of 2a was determined by X-ray crystallographic analysis. Desulfurization of 2a at −78 °C afforded a silicon−sulfur d

Microsatellites are short nucleotide repeat sequences present throughout the human genome. Alterations of microsatellites, comprising extra or missing copies of these sequences, have been termed microsatellite instability. This abnormality occurs in sporadic and hereditary adenocarcinomas of the proximal colon, as well as in many other tumor types. We determined whether microsatellite instability occurred in ulcerative colitis-associated cancers or precancerous dysplasias. Sixty-three patients w

In photosynthetic water oxidation performed in the water oxidizing center (WOC) of photosystem II (PSII), two water molecules are converted into one oxygen molecule and four protons through a light-driven cycle of intermediates called S states (S(0)-S(4)). To understand the molecular mechanism of water oxidation and the chemical nature of substrate intermediates, it is essential to determine the stoichiometry of proton release from substrate water at individual S-state transitions. In this study

Abstract Extremely hindered and stable disilenes (Tbt(Mes)Si=Si(Mes)Tbt {Tbt = 2,4,6-tris[bis(trimethylsilyl)methyl]phenyl, Mes = 2,4,6-trimethylphenyl. (Z)-1: cis-isomer, (E)-1: trans-isomer}) underwent dissociation under very mild conditions (ca. 70 °C) into a divalent silicon species (Tbt(Mes)Si: (2)), which was trapped by methanol, triethylsilane, 2,3-dimethyl-1,3-butadiene, elemental sulfur, and elemental selenium to afford the corresponding adducts in good yields. Silylene 2 reacted with s

Podoplanin (PDPN) is a cell-surface mucin-like glycoprotein that plays a critical role in tumor development and normal development of the lung, kidney, and lymphatic vascular systems. PDPN is overexpressed in several tumors and is involved in their malignancy. PDPN induces platelet aggregation through binding to platelet receptor C-type lectin-like receptor 2. Furthermore, PDPN modulates signal transductions that regulate cell proliferation, differentiation, migration, invasion, epithelial-to-me

Photosynthetic water oxidation takes place in the water-oxidizing center (WOC) of photosystem II (PSII). To clarify the mechanism of water oxidation, detecting water molecules in the WOC and monitoring their reactions at the molecular level are essential. In this study, we have for the first time detected the DOD bending vibrations of functional D 2O molecules during the S-state cycle of the WOC by means of Fourier transform infrared (FTIR) difference spectroscopy. Flash-induced FTIR difference