Tohoku University · Medicine
Professor Hisashi Shiga's research lab specializes in inflammatory bowel diseases (IBD), with a focus on optimizing treatment strategies for Crohn’s disease and ulcerative colitis. The lab investigates biomarker-guided, or 'tight control', management approaches using readily available serum markers such as CRP and albumin to improve clinical outcomes. Research also explores the impact of psychosocial stress—particularly post-disaster stress—on disease relapse, highlighting the interplay between mental health and IBD progression. Additionally, the lab contributes to endoscopic therapy research, particularly in the safe application of endoscopic submucosal dissection (ESD) in colorectal lesions by less experienced endoscopists.
Figures are computed from collected data and may differ slightly.
Endoscopists without experience in gastric ESD carried out colorectal ESD safely. In the early and middle phases (≤40 cases), they should treat mainly rectal lesions but may also resect lesions in the colon avoiding flexures. Lesions located at junctions and those with preoperative factors reflecting fibrosis should be resected after completing 40 procedures.
Life-event stress induced by the Great East Japan Earthquake was associated with relapse in UC but not CD.
Abstract Tight control management of Crohn’s disease (CD) based on biomarkers is more effective than conventional clinical management; however, fecal calprotectin is not allowed in Asian and some Western countries. To investigate whether tight control management based on readily available serum biomarkers results in better outcomes, we retrospectively reviewed treatment courses of consecutive Japanese CD patients treated with anti-tumor necrosis factor agents between 2003 and 2018. The associati
Relapse and later colectomy were associated with (1) disease activity at diagnosis and (2) lower levels of hemoglobin and albumin after the first induction therapy.
From the early phase of biologic treatment, both FC and LRG had high specificity for predicting ER at week 52. LRG showed higher sensitivity than FC.
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