Sungkyunkwan University · Medicine
Professor Ho Yeong Lim's research lab specializes in gastrointestinal oncology, with a primary focus on the molecular mechanisms underlying gastric carcinogenesis. The lab investigates the role of inflammatory mediators, particularly cyclooxygenase-2 (COX-2), in the development and progression of gastric adenocarcinoma. Utilizing immunohistochemical and molecular biological approaches, the lab explores potential chemopreventive strategies targeting COX-2 and related signaling pathways. Current research also extends to understanding the tumor microenvironment and identifying biomarkers for early detection and therapeutic intervention.
Figures are computed from collected data and may differ slightly.
Gastric adenocarcinoma is one of the most common malignancies in the world, and yet little is known about its molecular process of development and progression. Recent studies have suggested that ingestion of nonsteroid anti-inflammatory drugs reduces the risk of colon cancer, presumably by inhibiting the cyclooxygenase (COX) enzyme. COX-2, one isoform of the COX enzyme, is the rate-limiting enzyme in prostaglandin synthesis, and the function of this enzyme is thought to relate to inflammatory pr
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