Yonsei University · Medicine
Professor Hokyou Lee's research lab specializes in cardiovascular and metabolic health, with a focus on identifying early risk factors for cardiovascular disease in young and middle-aged adults. The lab investigates the interplay between hypertension subtypes, socioeconomic factors, and metabolic liver disease in predicting cardiovascular outcomes. Key research directions include risk stratification using blood pressure phenotypes, the impact of lifestyle and socioeconomic status on treatment adherence and mortality, and the role of liver fibrosis in systemic cardiovascular complications among patients with type 2 diabetes. The lab employs large-scale national cohort studies to translate clinical and epidemiological insights into preventive strategies.
Figures are computed from collected data and may differ slightly.
Among young adults, stage 1 ISH, IDH, and SDH were all associated with higher CVD risks than normal BP. The CVD risks of stage 1 ISH and IDH were similar to each other but lower than the risk of stage 1 SDH. Categorizing young adults with stage 1 hypertension further into stage 1 ISH, IDH, and SDH may improve risk stratification for identifying high-risk individuals.
Background Low socioeconomic status and poor medication adherence are known to be associated with increased morbidity and mortality among patients with hypertension, but their combined effects have not been studied. We therefore evaluated the joint association of household income and medication adherence with death and cardiovascular disease in patients newly treated for hypertension. Methods and Results This was a nationwide cohort study using the Korean National Health Insurance database. We i
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FLD was associated with a higher risk of CRC development. CRC risk was higher in the presence of MAFLD, especially when accompanied by liver fibrosis.
Liver fibrosis was associated with LV diastolic dysfunction in patients with T2DM and may be an independent risk factor for diastolic dysfunction, especially in patients without systemic insulin resistance.
title: Associations of Ideal Cardiovascular Health and Its Change During Young Adulthood With Premature Cardiovascular Events: A Nationwide Cohort Study, doi: 10.1161/CIRCULATIONAHA.121.054212, category: Article
title: Cardiovascular Risk of Isolated Diastolic Hypertension Defined by the 2017 American College of Cardiology/American Heart Association Blood Pressure Guideline: A Nationwide Age-Stratified Cohort Study, doi: 10.1161/HYPERTENSIONAHA.120.16018, category: Article
The 2017 American College of Cardiology/American Heart Association (ACC/AHA) high blood pressure (BP) guideline lowered the cut-off for hypertension, but its age-specific association with cardiovascular disease (CVD) remains inconclusive in different populations. We evaluated the association between high BP according to the 2017 ACC/AHA guideline and CVD risks in Koreans aged 20-94 years. In a nationwide health screening cohort, we included 15,508,537 persons aged 20-94 years without prior CVD.
Regional difference in hypertension management was evident in the past, but has become less apparent over the last 15 years in Korea.
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