Yonsei University · Medicine
Professor Hoon-Chul Kang's research lab specializes in pediatric epilepsy and therapeutic nutrition, with a primary focus on the ketogenic diet (KD) and its application in managing intractable childhood epilepsy. The lab investigates the safety, efficacy, and long-term outcomes of the KD and modified Atkins diet in children with epilepsy, particularly those with structural brain abnormalities such as cortical dysplasia. Research also explores neuropsychological outcomes associated with antiepileptic drugs and the optimal duration of dietary therapy to balance seizure control and growth preservation.
Figures are computed from collected data and may differ slightly.
Most complications of the KD are transient and can be managed easily with various conservative treatments. However, life-threatening complications should be monitored closely during follow-up.
The KD was a safe and effective therapy for seizures in children with intractable epilepsy and RC complex defects.
The KD is a safe and effective alternative therapy for intractable childhood epilepsy in Korea, although the customary diet contains substantially less fat than traditional Western diets, but life-threatening complications should be monitored closely during follow-up.
The modified Atkins diet was well tolerated and sometimes a modified Atkins diet can be substituted for the conventional ketogenic diet. Serious complications were rare, but long-term complications remain to be determined.
The pattern of neuropsychometric changes with TPM seemed to be slightly worse overall than CBZ. However, outcome with the minimum target dose did not differ significantly in comparisons between the treatment groups.
Use of the KD for only 8 months in children who become spasm-free appears to be justified, with similar outcomes, recurrence rate, and less growth disturbance than a longer-term, traditional use.
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