Hwa-Jin Lee

Tai Chi Qigong training appears to have beneficial effects in terms of the quality of life and physical functioning of elderly subjects with knee osteoarthritis. However, more rigorous trials are needed to confirm the efficacy of this training for patients with osteoarthritis of the knee.

Nitric oxide (NO) and tumor necrosis factor alpha (TNF-alpha) are the major mediators produced in activated macrophages which contribute to the circulatory failure associated with septic shock. A sesquiterpene lactone compound (dehydrocostus lactone) isolated from the medicinal plant, Saussurea lappa, inhibited the production of NO in lipopolysaccharide (LPS)-activated RAW 264.7 cells by suppressing inducible nitric oxide synthase enzyme expression. This compound also decreased the TNF-alpha lev

We have identified three differentially methylated regions associated with gestational age at birth. All three nearby genes play important roles in the development of several organs, including skeletal muscle, brain and haematopoietic system. Therefore, they may provide initial insight into the basis of PTB's negative health outcomes. The genome-wide custom DNA methylation array technology and novel statistical methods employed in this study could constitute a model for epidemiologic studies of

The combination of riluzole with sorafenib seems potent in suppressing tumor proliferation in vitro and in vivo in GRM1-expressing melanoma cells regardless of B-RAF genotype and may be a viable therapeutic clinical combination.

G-protein-coupled receptors (GPCR) are the largest family of receptors with over 500 members. Evaluation of GPCR gene expression in primary human tumors identified over-expression of GPCR in several tumor types. Analysis of cancer samples in different disease stages also suggests that some GPCR may be involved in early tumor progression and others may play a critical role in tumor invasion and metastasis. Currently, >50% of drug targets to various human diseases are based on GPCR. In this review

본 연구는 환경행동과 관련된 여러 연구들 중에서도 계획된 행동이론, 규범 활성화 모형, 가치-신념-규범 이론을 바탕으로 한 국내 연구 현황을 분석하고, 이를 바탕으로 향후 환경교육에서 나아가야 할 연구 방향에 대해 제시하고자 하였다. 이를 위해 2011년∼2020년까지 국내의 여러 학술지에 게재된 환경행동이론을 활용한 26개 논문들에 대해 연구대상, 연구방법, 활용이론, 환경행동 결정요인을 준거로 하여 분석하였다. 분석 결과, 최근 10년간 환경행동이론을 바탕으로 한 연구가 활발히 진행 중이지만, 대다수는 특정한 성인을 대상으로 이뤄져왔고 계획된 행동이론에 집중된 경향이 있다. 따라서, 향후 환경교육 분야에서 학생을 포함한 불특정 다수의 많은 사람들을 대상으로 할 필요성이 있고, 환경행동을 보다 잘 설명하기 위해 여러 이론들을 융합하여 연구할 필요성이 있다. 또한, 환경행동이 어떤 것인가에 따라 결정요인의 영향력의 정도가 달라지는지를 다양한 연구방법을 통해 알아볼 필요가 있겠다.

Six diarylheptanoids were isolated from the rhizome of Alpinia officinarum (Zingiberaceae) as inhibitors of nitric oxide (NO) production in the lipopolysaccharide-activated macrophage cell line RAW 264.7. A double bond at C-4 of the linker between two aromatic rings was found to be essential for activity. Furthermore, the active diarylheptanoids suppressed expression of the inducible NO synthase protein and mRNA. These results imply that the traditional use of Alpinia officinarum rhizome as anti

Limitation in cell sources for autologous cell therapy has been a recent focus in stem cell therapy and tissue engineering. Among various research advances, direct conversion, or transdifferentiation, is a notable and feasible strategy for the generation and acquirement of wanted cell source. So far, utilizing cell transdifferentiation technology in tissue engineering was mainly restricted at achieving single wanted cell type from diverse cell types with high efficiency. However, regeneration of

Adjustment of Middle-aged People with Hemiplegia after a Stroke Lee, Hwa Jin1)․Yi, Myungsun2) 1) Doctoral Candidate, Graduate School of Seoul National University; Researcher at the College of Nursing, Seoul National University 2) Professor at the College of Nursing, Seoul National University; Researcher, The Research Institute of Nursing Science, Seoul National University Purpose: The purpose of this study was to understand the adjustment process of middle-aged people in Korea with hemiple

Aberrant activation of a Wnt/β-catenin pathway results in nuclear accumulation of β-catenin in colon cancer. Inhibiting β-catenin is one strategy for treating colon cancer. Here, we identified Z-ajoene, a sulfur containing compound isolated from crushed garlic, as an inhibitor of colon cancer cell growth. Z-Ajoene repressed β-catenin response transcriptional activity, intracellular β-catenin levels, and its representative target protein levels (c-Myc and cyclin D1) in SW480 colon cancer cells. T