Ewha Womans University · Medicine
Professor Hyewon Park's research lab focuses on molecular and cellular mechanisms underlying cardiovascular diseases, with a particular emphasis on arrhythmias, ischemia-reperfusion injury, and the role of non-coding RNAs such as microRNAs and extracellular vesicles in cardiac protection and repair. The lab investigates signaling pathways including Wnt/GSK3β and calcium handling regulation, and explores the impact of environmental and metabolic factors—such as sodium benzoate and urban air pollution—on neuronal and cardiac cell function. A key direction involves identifying non-invasive biomarkers, such as urinary microRNAs, for early detection and pathophysiological insight into atrial fibrillation and other cardiac conditions.
Figures are computed from collected data and may differ slightly.
EV(HM) reduced IR injury by suppressing GSK3β expression via miRNA-26a and increased Cx43 expression. These findings suggest that the beneficial effect of EVHM is related with Wnt signaling pathway.
We incidentally found that osteoclast precursors and mature osteoclasts express Fas ligand (FasL) as well as Fas, which was confirmed by flow cytometry, immunofluorescent staining, and RT-PCR. The aim of this study was to determine the role of FasL in differentiation and cell death of osteoclasts. To study the role of FasL in osteoclastogenesis, neutralizing anti-FasL mAb or rFasL was added during receptor activator of NF-kappaB ligand (RANKL)-induced osteoclastogenesis using bone marrow-derived
These results suggest that unlike for other cancer types, the hOGG1 Ser326Cys polymorphism is not a major genetic risk factor for colorectal cancer.
Ewing sarcoma is a malignant bone cancer that primarily occurs in children and adolescents. Eighty-five percent of Ewing sarcoma is characterized by the presence of the aberrant chimeric EWS/FLI1 fusion gene. Previously, we demonstrated that an interaction between EWS/FLI1 and wild-type EWS led to the inhibition of EWS activity and mitotic dysfunction. Although defective mitosis is considered to be a critical step in cancer initiation, it is unknown how interference with EWS contributes to Ewing
Receptor activator of NFkappaB ligand (RANKL) is known as a key regulator of osteoclastogenesis. However, the fact that fibroblasts and periodontal ligament cells express RANKL in response to bacterial substances, suggests that RANKL may have evolved as a part of the immunity to infection. As RANKL increases the survival and activity of dendritic cells, it may have similar effects on macrophages. To address this issue, we studied the effect of RANKL on various functions of macrophages using mous
ABSTRACT Sodium benzoate (SB) is widely used in food chemistry, cosmetics and the pharmaceutical industry. Previous studies suggest possible toxic effects of SB when used as a food preservative. However, these studies were confined to microbiological systems. Therefore, we investigated the cytotoxic effects of SB in rat-cultured cortical neurons and in human clonal epithelial cells (HeLa cells) using cell death assays and the fluorescent measurements of intracellular Ca 2+ concentration ([Ca 2+
The purpose of this study was to validate the newly developed K-WPPSI-IV using other current IQ tests in common use in Korea such as the K-ABC and K-CTONI-2. Fifty three 27 year olds were tested with both the K-WPPSI-IV and K-ABC in a counterbalanced order. Simultaneous, cognitive, information processing as well as acquisition indices of K-ABC were moderately correlated with the total IQ of K-WPPSI-IV, ranging .44.58. The results of these tests were comparable with US data:
This study examined the reliability and validity evidence of the Korean version of Wechsler Primary & Preschool Scale for Intelligence(K-WPPSI-IV), which was standardized recently. Following the stratified sampling for Korean population in terms of region and maternal education level, 1,700 children aged 2.6~7.7 years were recruited for Korean norm development. The split-half reliability (N=1,700) was high(Fisher's z(.75-.89)) and test-retest reliability(N=100) was satisfactory ranging from .95
Htr3a is present in mouse hearts. Serotonin and Tph1 were increased during pregnancy. The deletion of Htr3a was related to fatal arrhythmias and sudden cardiac death during pregnancy, and its activation reversed the QT prolongation.
Korean adult transplant patients with less than 9 of 10 HLA allele matches in the HLA-A, -B, -C, -DRB1, and DQB1 loci have a higher likelihood of developing acute GVHD (grade II to IV). Impact of KIR ligand status on clinical outcome should be further studied in a larger patient population.
Type 1 diabetes (T1D) is frequently associated with other autoimmune diseases. Most T1D patients' sera contain two distinct glutamic acid decarboxylase (GAD) antibody specificities, of which one targets an epitope region in the middle-third of GAD65 (amino acids 221-359) and the other targets the carboxy-third of GAD65 (amino acids 453-569). Using five chimeric GAD65/GAD67 proteins to maintain conformation-dependent epitopes of GAD65, we compared the humoral repertoire of antibodies from 127 T1D
Ewing sarcoma is a pediatric bone cancer that expresses the chimeric protein EWSR1/FLI1. We previously demonstrated that EWSR1/FLI1 impairs the localization of Aurora B kinase to the midzone (the midline structure located between segregating chromosomes) during anaphase. While localization of Aurora B is essential for faithful cell division, it is unknown whether interference with midzone organization by EWSR1/FLI1 induces aneuploidy. To address this, we generated stable Tet-on inducible cell li
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