Yonsei University · Medicine
Professor Hyoung-Il Kim's research lab specializes in surgical oncology and translational immunometabolism, focusing on the interplay between systemic inflammation, nutritional status, and cancer outcomes. The lab investigates prognostic biomarkers such as the Prognostic Nutritional Index (PNI) in gastric cancer patients, aiming to improve surgical risk stratification and long-term survival prediction. Additionally, the lab explores innovative transplantation sites for pancreatic islets, evaluating their feasibility, engraftment efficiency, and metabolic outcomes to advance diabetes treatment. A key focus is also on post-gastrectomy iron deficiency and strategies to optimize nutritional recovery through surgical reconstruction techniques.
Figures are computed from collected data and may differ slightly.
To evaluate the predictive and prognostic significance of the prognostic nutritional index (PNI) in a large cohort of gastric cancer patients who underwent gastrectomy.Assessing a patient's immune and nutritional status, PNI has been reported as a predictive marker for surgical outcomes in various types of cancer.We retrospectively reviewed data from a prospectively maintained database of 7781 gastric cancer patients who underwent gastrectomy from January 2001 to December 2010 at a single center
ClinicalTrials.gov Identifier: NCT02892643.
Although the liver is the most common site for pancreatic islet transplantation, it is not optimal. We compared kidney, liver, muscle, and omentum as transplantation sites with regard to operative feasibility, and the efficiency of implantation and glycemic control. Islets from C57BL/6 mice were transplanted into diabetic syngeneic recipients. The mean operative time and mortality were measured to assess feasibility. To assess implantation efficiency, the marginal mass required to cure diabetes
NCT01283893.
Iron deficiency occurs in most patients with gastric cancer after gastrectomy, and its incidence was different according to the extent of gastrectomy and reconstruction method. To improve iron metabolism after distal gastrectomy, gastroduodenostomy would be the method of reconstruction whenever possible.
A higher regulatory T cells/helper T cells ratio is associated with an unfavorable prognosis and loco-regional recurrence pattern in gastric cardia cancer.
Multivariate analysis using total IEQ and IEQ/g as outcome variables indicated that age older than 2, being male and moderate distension by Liberase injection are major determinants influencing successful islet isolation.
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