Yonsei University · Biochemistry, Genetics and Molecular Biology
Hyun Woo Park 교수의 연구실은 생물의학적 이온 채널과 전기생리학을 중심으로, 특히 CFTR 및 WNK4 등 전사적·기능적 이상이 관련된 질병의 분자 기전을 규명하는 데 초점을 맞추고 있습니다. 고도로 정밀한 이온 운반 메커니즘과 세포 내 산화 스트레스 반응, 특히 칼슘 유입 조절을 통한 혈압 조절 기전에 대한 기초 연구를 진행하고 있으며, 이는 고혈압 및 낭포성 섬유증과 같은 유전성 질환의 치료 전략 개발에 기여합니다. 또한, 신경 및 종양 생물학적 맥락에서의 이온 채널 기능과 그 기능 이상이 질병 진행에 미치는 영향을 다각도로 분석하고 있습니다.
Figures are computed from collected data and may differ slightly.
The study confirms that smoking places a substantial economic burden on Korean society. In light of this, our study provides evidence for a strong need to develop a national policy to effectively control tobacco consumption in Korea.
In hyper scale data centers, high-speed links beyond 100Gb/s are required by applications such as XSR (co-packaged optics and die-to-die interconnects) or LR (ethernet switches, ASICs, and retimers). This work presents a 112Gb/s LR SerDes system with a DSP-based PAM-4 transceiver for large-scale switching ASICs (25.6∽51.2Tb/s). For a compact and low-cost system configuration, each lane is recommended to drive more than 40dB channel loss [1–4] without repeaters. Maximum heat capacity of a package
Many cystic fibrosis transmembrane conductance regulator (CFTR)-expressing epithelia secrete bicarbonate (HCO(3)(-))-containing fluids. Recent evidence suggests that defects in epithelial bicarbonate secretion are directly involved in the pathogenesis of cystic fibrosis, in particular by building up hyperviscous mucus in the ductal structures of the lung and pancreas. Pancreatic juice is one of the representative fluids that contain a very high concentration of bicarbonate among bodily fluids th
Voltage-gated potassium (Kv) channels are involved in many important cellular functions and play pivotal roles in cancer progression. The expression level of Kv2.1 was observed to be higher in the highly metastatic prostate cancer cells (PC-3), specifically in their membrane, than in immortalized prostate cells (WPMY-1 cells) and comparatively less metastatic prostate cancer cells (LNCaP and DU145 cells). However, Kv2.1 expression was significantly decreased when the cells were treated with anti
Mutations in the serine-threonine kinase with-no-lysine 4 (WNK4) cause pseudohypoaldosteronism type 2 (PHAII), a Mendelian form of human hypertension. WNK4 regulates diverse ion transporters in the kidney, and dysregulation of renal transporters is considered the main cause of the WNK4 mutation-associated hypertension. Another determinant of hypertension is vascular tone that is regulated by Ca(2+)-dependent blood vessel constriction. However, the role of WNK4 in vasoconstriction as part of its
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